Neonatal Magnesium Disturbances

Tsang, Reginald C.

doi:10.1001/archpedi.1972.02110140132019

Cited by 17 publications

(10 citation statements)

References 31 publications

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“…Hypomagnesaemia is frequently a factor in neonatal tetany (Tsang, 1972;Cockburn, et al, 1973) and various factors such as a high phosphate load (Anast, 1964;Coussons, 1969), impaired magnesium absorption (Paunier et al, 1965;Salet et al, 1966), target unresponsiveness (Seelig, 1971), and transitory functional hypoparathyroidism (Davis et al, 1965) appear to contribute to it. Neonatal hypocalcaemia may respond to magnesium but not to calcium (Paunier et al, 1965;Davis et al, 1965;Salet et al, 1966), and Turner et al (1975) have shown that intramuscular magnesium sulphate is a more rapid and effective treatment of an established case of neonatal hypocalcaemia than either oral calcium gluconate or oral phenobarbitone.…”

Section: Discussionmentioning

confidence: 99%

Clinical and biochemical assessment of a modified evaporated milk for infant feeding.

Belton¹,

Cockburn²,

Forfar³

et al. 1977

Archives of Disease in Childhood

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SUMMARY A clinical and biochemical evaluation has been made of a new milk formula, Modified Carnation milk (MCM), based on cows' milk but with the mineral content and concentration of caloric nutrients altered to make it correspond more closely to human milk. MCM produced higher plasma calcium and magnesium concentrations in 6-day-old infants than those produced by unmodified evaporated and dried milks, achieving concentrations closer to those of breast milk. Plasma free amino acid concentrations in MCM-fed infants are nearer breast-fed values than those in unmodified milk-fed infants where higher individual plasma amino acid concentrations persist during the first 3 months. MCM-fed infants had low plasma urea concentrations and lower urine osmolalities at 6 days, 3 weeks, 6 weeks, 3 months, and 6 months than infants fed on the evaporated and dried milks, and similar plasma urea and urine osmolalities to those of breast-fed infants.MCM is likely to be superior to unmodified evaporated and dried milks in preventing convulsions of the hypocalcaemic/hypomagnesaemic/hyperphosphataemic type, and seems less likely to cause hypertonic dehydration. MCM is easily prepared, readily accepted by babies, and appears to be nutritionally adequate for the feeding of term infants.

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Section: Discussionmentioning

confidence: 99%

Clinical and biochemical assessment of a modified evaporated milk for infant feeding.

Belton¹,

Cockburn²,

Forfar³

et al. 1977

Archives of Disease in Childhood

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“…Formula have been reported to contain 40 to 70 mg/L (6 to 12 mg/100 kcal) (LSRO 1998). High doses of magnesium are toxic, and untoward effects have been reported in newborn infants treated with antacids or whose mothers were treated with magnesium sulfate for hypertensive disorders of pregnancy (Tsang 1972; Brand and Greer 1990). Magnesium toxicity from formulae has not been reported.…”

Section: Minerals and Trace Elementsmentioning

confidence: 99%

Aspects of Infant Food Formulation

Thompkinson¹,

Kharb²

2007

Comp Rev Food Sci Food Safe

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Milk is a biological fluid of exceptional complexity. It contains the nutrients for the growth and development of the newborn. The compositional structure of milk is, however, dependent on the species and tailored to sustain growth and development of its own offspring. Human milk contains specific proteins, lipids, and other components designed to be easily digestible and which have important roles to play in child development. Human infants should ideally be nursed on mother's milk, which constitutes nature's best food. However, in the event of lactation failure, insufficient milk secretion, and where mothers are suffering from transmittable diseases, human milk substitutes serve as savers of precious life during vulnerable stages of infancy. Bovine milk as such or with certain modifications has been widely used for infant feeding. There has been an ever-increasing reliance on formula feeding practices both in developed and developing countries. Bovine milk based dried formulations have become a prominent feature of infantile dietetics. Emphasis has been laid on the manufacture of formulations having compositional and biochemical characteristics similar to human milk. The technological advancement for the production of infant formula has come a long way in the manufacture of a variety of infant formulae for the dietary management of infants. This is a comprehensive review providing insight on the detailed compositional differences of various nutrients present in human milk as compared to bovine milk, their makeup, significance, and recommended levels of intake that are best suited for the growth and development of infants fed on modified/prepared infant formulations.

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“…Several studies have documented the impact of prematurity on the alteration of Mg metabolism in the neonate. [12][13][14] Magnesium homeostasis is also linked with calcium, another electrolyte that has important physiological functions. 15,16 Under these circumstances, the investigation of Mg, especially its biologically active ionized (IMg) fraction 14 in association with prematurity is important in the prediction and management of early magnesium imbalance in preterm born infants.…”

mentioning

confidence: 99%