Neonatal lupus erythematosus in Japan

Kaneko, Fumio; Tanji, Osamu; Hasegawa, Tsukasa; Ohto, Hitoshi; Yamazaki, Keiji

doi:10.1016/0190-9622(92)70061-j

Cited by 62 publications

(21 citation statements)

References 15 publications

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“…There have also been some reports of resulting atrophy and telangiectasia (9,10). In cases of cutaneous NLE reported fi'om Japan, skin lesions are sitnilar to annular reactive erythemas without an epidermal component (11,12). Case 2 had both kinds of eruptions.…”

Section: Discussionmentioning

confidence: 92%

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Borrego

Rodríguez

Soler

et al. 1997

Pediatric Dermatology

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Neonatal lupus erythematosus (NLE) is an autoimmune disease whose major findings are skin lesions and congenital heart block. Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases. Mothers of babies with NLE may be asymptomatic initially or may have Sjögren syndrome, lupus erythematosus, overlap syndrome or, uncommonly, leukocytoclastic vasculitis. When evaluating a young woman with a cutaneous leucocytoclastic vasculitis, dermatologists should be aware of the possible presence of antibodies related to NLE. If any patient suffering a disorder related to NLE becomes pregnant, testing for autoantibodies and close obstetric prenatal care with fetal echocardiogram is necessary. In cases of fetal bradycardia, treatment with dexamethasone or betamethasone should be considered, as these drugs are accessible to the fetal circulation.

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Section: Discussionmentioning

confidence: 92%

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Borrego

Rodríguez

Soler

et al. 1997

Pediatric Dermatology

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“…In Japan, only 8% of patients with NLE have CHB, in contrast to 68% in Europe and America 9,10 . Because of this, we could study the mothers of only two patients with NLE and CHB, and thus could not assess differences between the SS‐A 52‐ and 60‐kDa proteins and the SS‐B 50‐kDa protein in these subjects.…”

Section: Discussionmentioning

confidence: 99%

Immune responses to SS-A 52-kDa and 60-kDa proteins and to SS-B 50-kDa protein in mothers of infants with neonatal lupus erythematosus

Yukiko

2000

British Journal of Dermatology

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Mothers who have anti-SS-A/Ro and anti-SS-B/La antibodies have a greater risk of bearing infants with neonatal lupus erythematosus (NLE). However, most mothers with anti-SS-A/Ro and anti-SS-B/La antibodies give birth to infants with no evidence of NLE. We studied mothers who had the combination of clinical evidence of connective tissue disorder, positive antinuclear antibody and positive anti-SS-A/Ro and/or anti-SS-B/La antibodies. We analysed SS-A/Ro and SS-B/La antibody responses to recombinant 60-, 52- and 50-kDa proteins in eight mothers of NLE infants and 19 mothers whose children did not have NLE. Molecular analysis of the anti-SS-A/Ro and anti-SS-B/La antibodies was carried out by enzyme-linked immunosorbent assay using recombinant 60-, 52- and 50-kDa proteins. The mothers of children with cutaneous NLE were all positive for a high titre of 50-kDa protein. Mothers of children with NLE with complete heart block (CHB) were positive for 52- and 60-kDa proteins. We conjecture that anti-SS-B/La antibody influences the development of cutaneous NLE, and that anti-SS-A/Ro antibody influences the development of NLE with CHB.

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“…In cases of neonatal LE (NLE), it is well known that the human leukocyte antigen (HLA)‐DR3 phenotype, which is found in the great majority of Caucasian mothers of NLE infants, is absent in Japanese mothers. Significantly high relative risk of HLA‐DRw12 was reported in Japanese infants with NLE, 5 which is different from that of Caucasian patients reported in the literature 6 . Miyagawa studied HLA‐DR and ‐DQ distributions in NLE and demonstrated that maternal HLA‐DR5 haplotype bearing DRB1*1101‐DQA1*0501‐DQB1*0301 was associated with neonatal cutaneous lupus but not congenital heart blocks (CHB), which associated with HLA‐ DR2 haplotype (including HLA‐DQB1*0602) 7 …”

Section: Genetic Basis Of Japanese Patients With Cutaneous Lementioning

confidence: 98%

Race Differences in Immunogenetic Features and Photosensitivity of Cutaneous Lupus Erythematosus from the Aspect of Japanese Studies

Furukawa

Yamamoto

Kanazawa

et al. 2009

Annals of the New York Academy of Sciences

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Skin lesions of collagen diseases are influenced by environmental triggers, such as UV light, and are variable in cutaneous lupus erythematosus (LE), such as systemic LE (SLE), chronic discoid LE (CDLE), subacute cutaneous LE (SCLE), and LE tumidus (LET). Although there are a few conflicting reports on photosensitivity in collagen diseases, many Japanese dermatologists feel there are photosensitivity differences in LE between Asians and Caucasians with SCLE and LET. To address this issue, we have carried out genetic studies of Japanese SLE and CDLE patients and reviewed the race differences in photosensitivity of cutaneous LE from Japanese studies. Human leukocyte antigen (HLA) studies in Japanese patients revealed that HLA-DRB1*1501 association was with CDLE and SLE. The association between HLA-Cw6 and CDLE was first reported in a Japanese population, and a HLA-A33-B44-DRB1*1302 haplotype showed a positive association in CDLE. However, these results are not compatible with those from Caucasian subjects. There are no significant associations among HLA studies, photosensitivity, and anti-Ro/SS-A antibodies in Japanese CLE patients. Photosensitivity will be a key factor to dissolve multifactorial complexes of LE etiopathogenesis. An axis of photosensitivity, anti-Ro/SS-A antibodies, and apoptosis via tumor necrosis factor-alpha is the best marker to verify the contribution of genetics in CLE patients. The incidence and degree of photosensitivity of SCLE and LET are much lower in Japanese than in Caucasians. This discrepancy may lead to investigations of CLE pathogenesis through global collaborations.

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Neonatal lupus erythematosus in Japan

Cited by 62 publications

References 15 publications

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

Immune responses to SS-A 52-kDa and 60-kDa proteins and to SS-B 50-kDa protein in mothers of infants with neonatal lupus erythematosus

Race Differences in Immunogenetic Features and Photosensitivity of Cutaneous Lupus Erythematosus from the Aspect of Japanese Studies

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