Neonatal<i>Escherichia coli</i>infection in twins: clinical spectrum and management dilemma

Ehman, Dylan; Samedi, Veronica Mugarab; Kalaniti, Kaarthigeyan; Daspal, Sibasis

doi:10.1136/bcr-2020-238470

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…A limited number of nosocomial lower respiratory tract infections were linked to Escherichia coli. Aspiration and mechanical ventilation were identified as risk factors for this condition [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Iancu,

Moldovan,

Țilea

et al. 2023

Antibiotics

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Background: Hospital-acquired infections (HAIs) pose a significant danger to global public health, mainly because their numbers are growing exponentially each year. Additionally, the rise of bacterial strains resistant to current treatment options further exacerbates this threat. This study aimed to examine the occurrences of HAIs identified in public hospitals at the county level. Methods: We conducted a cross-sectional study utilizing data provided to the Mures Public Health Directorate from all the public hospitals within the studied county. We examined HAIs reported during the period spanning from 2017 to 2021, which amounted to a total of 4603 cases. Results: The medical departments reported the highest prevalence of HAIs at 48.25%. The most common infections included enterocolitis with Clostridioides difficile (32.61%), COVID-19 (19.83%), bronchopneumonia (16.90%), sepsis, surgical wound infections, and urinary tract infections. The five most frequently identified pathogens were Clostridioides difficile (32.61%), SARS-CoV-2 (19.83%), Acinetobacter baumannii (11.82%), Klebsiella pneumoniae (9.58%), and Pseudomonas aeruginosa (7.95%). Acinetobacter baumannii was the predominant agent causing bronchopneumonia, while Klebsiella pneumoniae was the leading cause of sepsis cases. Escherichia coli was the primary agent behind the urinary tract infections, and Staphylococcus aureus MRSA was identified as the main etiology for wound infections and central catheter infections. Throughout the study period, there was a significant rise in Clostridioides difficile and Gram-negative bacteria prevalence rates. Conclusions: This study identified increased Clostridioides difficile in HAI cases during COVID-19, highlighting the need for careful antibiotic use and emphasizing the growing challenge of multi-resistant strains in post-pandemic state hospitals.

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Section: Discussionmentioning

confidence: 99%

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Iancu,

Moldovan,

Țilea

et al. 2023

Antibiotics

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show abstract

“…In recent years, E. coli has surpassed group B Streptococcus as the most important etiological agent of bacteremia in neonates in both preterm and term groups. Despite strict infection control programs in various countries, E. coli is the most common cause of severe infections such as meningitis with a mortality rate of over 40% [12,13] . In this study, the most common Gram negative organism isolated was E. coli, which is consistent with other literature [14][15][16] , but in contrast to other Iranian studies in which P. aeruginosa has been reported as the most prevalent organism [17,18] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiotic Susceptibility of Escherichia coli Isolated from Early-Onset Sepsis in Shiraz, Iran

Rezaei

Javanmardi

Pirbonyeh

et al. 2021

IEM

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Background: Neonatal sepsis is a clinical syndrome in neonates, which is an uncommon but significant cause of morbidity and mortality in infants. The aim of this study was to evaluate the incidence of sepsis caused by Escherichia coli and its antibiotic resistance pattern as well as to assess the potential risk factors in neonates and maternal characteristics in Shiraz.Material & Method: This retrospective study was performed on infants with sepsis in the first three days of life during February 2019 to March 2021. Patients' information was obtained using their hospital records and a questionnaire. All statistical analyses were conducted using SPSS software Ver. 18.0. A p-value <.05 was considered as statistically significant Findings: During this study, a total of 250 positive blood cultures were reported for infants less than 3 days old. Of these, 21(8.4%) E. coli strains were isolated from 14 preterm and 7 term neonates. In all patients, the most effective antibiotic was meropenem, and the highest resistance was observed to cefoxitin. Conclusion:Base on the present study results, E. coli is the most prevalent Gram-negative bacterium isolated in Shiraz. Premature birth and very low weight are the most important risk factors for developing early-onset sepsis.

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Evaluating Healthcare-Associated Infections in Public Hospitals: A cross-sectional Study

Iancu,

Moldovan,

Țilea

et al. 2023

Preprint

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Background: Hospital-acquired infections (HAI) pose a significant danger to global public health, mainly because their numbers are growing exponentially each year. Additionally, the rise of bacterial strains resistant to current treatment options further exacerbates this threat. The study aimed to examine the occurrences of HAIs identified in public hospitals at the county level. Methods: We conducted a cross-sectional study utilizing data provided to the Mures Public Health Directorate from all the public hospitals within this county. We examined HAIs reported during the period spanning from 2017 to 2021, which amounted to a total of 4603 cases. Results: The medical departments reported the highest prevalence of HAIs at 48.25%. The most common infections in-cluded enterocolitis with Clostridioides difficile (32.61%), COVID-19 (19.83%), bronchopneumonia (16.90%), sepsis, surgical wound infections, and urinary tract infections. The five most frequently identified pathogens were Clostridioides difficile (32.61%), SARS-CoV-2 (19.83%), Acinetobacter baumannii (11.82%), Klebsiella pneumoniae (9.58%), and Pseudomonas aeruginosa (7.95%). Acinetobacter baumannii was the predominant agent causing bronchopneumonia, while Klebsiella pneumoniae was the leading cause of sepsis cases. Escherichia coli was the primary agent behind urinary tract infec-tions, and Staphylococcus aureus MRSA was identified as the main etiology for wound infections and central catheter infections. Throughout the study period, there was a significant rise in Clostridioides difficile cases, accounting for 40.36% of all reported HAIs in 2021. Conclusions: The study identifies Clostridioides difficile increase in HAI cases during COVID-19, highlighting the need for careful antibiotic use, and emphasizing the growing challenge of multi-resistant strains in post-pandemic state hospitals.

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NeonatalEscherichia coliinfection in twins: clinical spectrum and management dilemma

Cited by 3 publications

References 21 publications

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Prevalence and Antibiotic Susceptibility of Escherichia coli Isolated from Early-Onset Sepsis in Shiraz, Iran

Evaluating Healthcare-Associated Infections in Public Hospitals: A cross-sectional Study

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