Neonatal<i>Citrobacter koseri</i>Meningitis: Report of Four Cases

Rodrigues, Jaime; Rocha, Dalila; Santos, F; João, Anabela

doi:10.1155/2014/195204

“…Importantly, C. koseri has been associated with the majority of Citrobacter infectious diseases, including neonatal meningitis, brain abscesses and pneumonia underlying pulmonary adenocarcinoma [24–26]. Moreover, C.…”

Section: Discussionmentioning

confidence: 99%

Citrobacter koseri stimulates dendritic cells to induce IL-33 expression via abundant ATP production

Kataoka

¹

,

Mori

²

,

Into

³

2021

Journal of Medical Microbiology

View full text Add to dashboard Cite

Introduction. Food allergies (FAs) occur due to intestinal immune dysfunction elicited by dysbiotic conditions. It was previously determined by us that Citrobacter species propagate in the faeces of mice with FAs and worsen allergic symptoms by inducing the allergenic cytokine IL-33. Dendritic cells can play important roles in regulation of FA responses. Hypothesis. Citrobacter species propagating in intestines of mice worsen allergic symptoms by stimulating dendritic cells to induce IL-33 expression. Aim. The aim of the present study was to analyse whether C. koseri stimulates dendritic cells to induce IL-33 expression. Methodology. IL-33 expression was evaluated in a DC2.4 mouse dendritic cell line stimulated by live or heat-inactivated C. koseri JCM1658, ATP, LPS extracted from C. koseri JCM1658 or other enterobacteria by real-time PCR. The ATP concentration and number of live bacteria in the culture supernatant were measured simultaneously. Results. Live C. koseri JCM1658 induced higher levels of IL-33 expression than other enterobacteria tested, but such a response was not elicited by heat-inactivated C. koseri JCM1658. LPS extracted from C. koseri JCM1658 did not induce IL-33 expression and suppressed live C. koseri JCM1658-induced IL-33 expression via the activation of Toll-like receptor 4 signalling. Furthermore, ATP produced by C. koseri JCM1658 stimulated dendritic cells to induce IL-33 expression by stimulating the P2X7 receptor, and LPS attenuated extracellular ATP-induced IL-33 expression. C. koseri JCM1658 was observed to proliferate more vigorously and produce more ATP than other enterobacteria. Conclusion. C. koseri acts as an allergenic bacterium through ATP production, stimulating dendritic cells to induce IL-33 expression, while LPS released from inactivated C. koseri JCM1658 attenuates this allergenicity.

show abstract

“…Various types of neurological disorders are observed in about 50–80% of children who survive Citrobacter koseri infections complicated by brain abscesses [ 2 , 3 , 4 ]. It is claimed that Citrobacter koseri may be transferred vertically from the mother to the child, but there is no evidence that this route of bacterial transfer is responsible for brain absences in premature neonates [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is claimed that Citrobacter koseri may be transferred vertically from the mother to the child, but there is no evidence that this route of bacterial transfer is responsible for brain absences in premature neonates [ 4 ]. Oftentimes, bacterial transfer occurs horizontally from hospital personnel [ 3 , 4 ]. However, the source of infection in our patient remains unclear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Brain Abscesses Caused by Citrobacter Koseri in a Preterm Neonate – Case Report

Lechowicz

¹

,

Dąbek

²

,

Majewska

³

et al. 2018

View full text Add to dashboard Cite

SummaryBackgroundBrain abscesses are very rarely diagnosed in neonates, but if present, they are associated with a high risk of severe complications and mortality. In neonates, brain abscesses can be detected on transfontanelle ultrasonography, in which they appear as hyperechogenic lesions surrounded by a hypoechogenic border.Case ReportWe present a female neonate, born in the 28th week of gestation, with birth weight of 950 grams, who was born in an ambulance by spontaneous vaginal vertex delivery. No signs of infection were present until the 35th day of hospitalization, when a sudden and serious deterioration in the patient’s condition was observed due to late-onset sepsis. Cranial US, performed on the 40th day of life, revealed hyperechogenic lesions with a hypoechogenic halo in the right frontal lobe, which could correspond to brain abscesses. These lesions were caused by Citrobacter koseri septicaemia, identified by transfontanelle ultrasonography, and confirmed on magnetic resonance imaging. The patient recovered and was discharged on the 91th day of life (39 PCA) with a recommendation of permanent neurological surveillance.ConclusionsUltrasonography of the central nervous system can reveal inflammatory changes and developing brain abscesses. In neonates, magnetic resonance imaging should be performed as the method of choice for confirming brain abscesses.

show abstract

“…Talora queste infezioni sono polimicrobiche e frequentemente risultano correlabili a procedure invasive: le condizioni più comuni sono rappresentate dalle infezioni del tratto urinario, seguite dalle infezioni intraddominali, talora post-chirurgiche, e dalle infezioni dei tessuti molli e del tratto respiratorio [10]. Citrobacter koseri in epoca neonatale è in grado di determinare osteomieliti e gravi infezioni del sistema nervoso centrale con un alto tasso di mortalità e postumi neurologici [11][12][13].…”

Section: Conclusioniunclassified

[A rare case of sepsis from Citrobacter koseri in adults]

Pistoia

¹

,

Ciola

²

,

Sala

³

et al. 2021

CMI

0

View full text Add to dashboard Cite

We describe the case of a 53-year-old man, recently diagnosed with decompensated type II diabetes mellitus, admitted to our Department for fever, asthenia, and detection of multiple lung abscesses and pulmonary embolism at chest tomography.His clinical history revealed just a recent orthopedic surgery of osteosynthesis on the left wrist with normal clinical and instrumental post-surgical evolution. Empirical antibiotic therapy with piperacillin/tazobactam and clindamycin was initiated. During hospital stay, swelling and functional impotence in the right knee occurred. They were investigated by arthrocentesis and magnetic resonance, and diagnosed as septic arthritis.Blood culture performed at admission tested positive for Citrobacter koseri on several samples where meropenem was added according to antibiogram. On the other hand, the cultures of bronchoaspirate, pulmonary fine needle aspiration, and arthrocentesis were negative.Antibiotic therapy was administered up to two weeks after discharge and radiological and physical features progressively improved.

show abstract

NeonatalCitrobacter koseriMeningitis: Report of Four Cases

Cited by 6 publications

References 9 publications

Citrobacter koseri stimulates dendritic cells to induce IL-33 expression via abundant ATP production

Citrobacter koseri stimulates dendritic cells to induce IL-33 expression via abundant ATP production

Multiple Brain Abscesses Caused by Citrobacter Koseri in a Preterm Neonate – Case Report

[A rare case of sepsis from Citrobacter koseri in adults]

Contact Info

Product

Resources

About