Neonatal Hypoglycemia: Risk Factors and Outcomes

Stomnaroska, Orhideja; Petkovska, Elizabeta; Jancevska, Snezana; Danilovski, Dragan

doi:10.1515/prilozi-2017-0013

Cited by 19 publications

(21 citation statements)

References 27 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In current study birth asphyxia was more common neonatal risk factor than early septicaemia and RDS which was similar to study done by Dhananjaya CP et al, Burden et al and Manjunatha BR et al 11,14,12 Early septicemia was more common in the study done by Indira P et al and Stomnaroska et al and RDS was more common in the study by Bhand SA et al so that these are not similar to current study. 13,17,16 Most common symptoms of hypoglycemia were poor feeding, lethargy, jitteriness, seizure and respiratory abnormality which was similar to study done by Dhananjaya 11,13,16,18,12,8,10,15 In the current study, blood glucose level below 30 mg/dl was more commonly seen in neonates having more than one episode of hypoglycemia. The blood glucose levels at admission were in lower range in neonates who later had repeat episode of hypoglycemia.…”

Section: Discussionsupporting

confidence: 83%

Clinico-biochemical profile of hypoglycemia in neonates admitted in NICU

Singh¹,

Kher²

2018

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: In high risk neonates’ incidence of hypoglycemia is up to 30%. There is limited evidence-based consensus regarding screening and management of neonates at risk of hypoglycemia. This study was undertaken to know the incidence, clinical profile, sequential blood glucose level upto 72 hours and short-term outcome of neonatal hypoglycemia.Methods: Blood sugar was screened at admission, after feed or D10 bolus, 6, 12, 24, 48 and 72 hours of age. Detailed maternal history and neonatal history, clinical manifestation, management and short-term outcome of hypoglycemic neonates were noted. Statistical analysis of data was done by SPSS 22.0 software.Results: 200 neonates with blood glucose less than 40mg/dl at admission to NICU in which 47 had repeat episode of hypoglycemia. Incidence of hypoglycemia at admission was 22.49% and 5.29% was incidence of repeat episode of hypoglycemia. Pre-term (p=0.005), low birth weight (p=0.020) and SGA (p=0.012) had repeat episode of hypoglycemia. GDM (p=0.040), birth asphyxia (p=0.046) and early septicaemia (p=0.0001) were common risk factors for hypoglycemia. Poor feeding, jitteriness and respiratory abnormality were common presentation of hypoglycemic neonates. The blood glucose levels at admission were less than 30 mg/dl in neonates who later had repeat episode of hypoglycemia. Most hypoglycemic episode after admission occurred within 24 hours of life.Conclusions: LBW especially Preterm SGA neonates are at increased risk of hypoglycemia. Maternal and neonatal risk factors are GDM and birth asphyxia, early septicaemia. Screening for hypoglycemia is essential for high-risk neonates.

show abstract

Section: Discussionsupporting

confidence: 83%

Clinico-biochemical profile of hypoglycemia in neonates admitted in NICU

Singh¹,

Kher²

2018

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…In a study done by Stomnaroska, et al found neonatal hypoglycemia was a signi icant factor in the overall neonatal mortality and infections, But Spearman tests showed weak direct correlation, without statistical signi icance [19]. Similar indings was found on a Study done by Islam, et al [20], showing that mortality was higher among the septic newborn with hyperglycemia (50%) compared to normoglycaemic patient (10.8%) and the difference was statistically signi icant (p < 0.05) between two groups [20]. Yadav, et al found the incidence of culture positive sepsis was 6.5% of the total cases of suspected sepsis, which was much lower than the present study [21].…”

Section: Discussionsupporting

confidence: 66%

Glycemic status and its effect in Neonatal Sepsis - A prospective study in a Tertiary Care Hospital in Nepal

Gupta¹,

Gupta²,

Shrivastava³

et al. 2019

J Adv Pediatr Child Health

View full text Add to dashboard Cite

Introduction: Sepsis is an important cause of morbidity and mortality among neonates. Neonatal sepsis can alter the glucose level and both hypoglycemia and hyperglycemia may occur. A high or low blood glucose level may have a signifi cant effect on the outcomes in patients of neonatal sepsis. Aims:The aim of the study to see the glycaemic status and its effect on outcome of neonatal sepsis. Material and Methods:This hospital based prospective observational cross-sectional study was conducted in Neonatal Intensive Care Unit in Universal College of Medical Sciences, a tertiary care hospital over a period of 4 months, from May 2019 to August 2019. A total of 220 Neonates suspected sepsis under the age of 28 days admitted in NICU, were studied and included in our study. Clinically suspected neonatal sepsis cases were enrolled in the study. Venous blood was collected before giving any intravenous fl uid, dextrose or antibiotics and blood sugar, complete blood counts, CRP levels and blood culture were send to laboratory within half hour of collection. All patients included in this study were treated accordingly and followed up strictly. Blood glucose level and mortality of neonates having hypoglycemia, hyperglycemia were analyzed among CRP and culture positive patients. Quantitative data were expressed as mean and standard deviation. Qualitative data were expressed as frequency and percentage and comparison carried by Chi-square (χ2) test.Results: A total of 220 patients clinically diagnosed as neonatal sepsis were studied. 118 (53.6%) patients were found CRP positive and 56 (25.5%) patients were blood culture positive. Glycaemic status was analyzed among CRP and culture positive patients. Majority (55.9%) patients were found normoglycemic, 35.5% were found hypoglycemic and 8.6% were found hyperglycaemic in this study. 182 (82.73%) patients were cured and 38 (17.27%) died. Mortality was high in hypoglycaemic patients (34.4%) compared with normoglycaemic patients (9.82%), but the difference was not statistically signifi cant (p > 0.05) between two groups, the mortality was high in hyperglycaemic patients (58.33%) compared with normoglycaemic patients (9.82%) and the difference was statistically signifi cant (p < 0.05) between two groups. Conclusion:Alteration of glycaemic status occurred in septic newborn. Mortality is higher among the septic newborn with hyperglycemia. The present study found that majority of neonate with sepsis had high mortality rate when blood glucose level were either more than 145 mg/dl or less than 45 mg/ dl. This signifi es the importance of meticulous blood glucose estimation in cases of neonatal sepsis to improve mortality outcome.

show abstract

“…Severe and prolonged hypoglycemia can result in serious neurodevelopmental abnormalities and can cause death. Therefore, timely identi cation of risk factors and interventions prevent neonates from unwanted complications of hypoglycemia [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk factors of Hypoglycaemia in Neonates at St. Paul’s Hospital Millennium Medical College Neonatal Intensive Care Unit, Ethiopia: A Cross Sectional Study

Fantahun¹,

Nurussen²

2020

Preprint

View full text Add to dashboard Cite

Background Hypoglycaemia is a common metabolic abnormality seen in neonates that can cause preventable death. Its overall incidence has been estimated to be 1 to 5 per 1,000 live births, with higher incidence in at-risk populations. There is limited data regarding its prevalence and risk factors in developing countries like Ethiopia. Therefore, this study was aimed to determine the prevalence and risk factors of neonatal hypoglycaemia in neonatal intensive care unit (NICU) at Saint Paul’s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia. Methodology A cross sectional study was conducted from June 17 to August 3, 2018 at SPHMMC, NICU. Neonates whose age was less than 48hrs and admitted to NICU were enrolled. Sociodemographic, maternal and neonatal factors were collected using structured questionnaire. Blood glucose was measured using glucometer with a test strip. Random blood glucose level < 47mg/dl was taken as a cut-off point to define hypoglycaemia. The data was entered and analysed using SPSS version 20. Results Neonatal hypoglycaemia was detected in 25% (49/196) of the neonates. Birth weight, duration of labor, maternal age, time of feeding initiation, hypothermia and respiratory distress syndrome were associated with hypoglycaemia. From these factors, maternal age, birth weight and hypothermia were found to be independent predictors of the outcome. Conclusion Hypoglycaemia was prevalent in neonates admitted to the NICU of SPHMMC and was associated with low birth weight and hypothermia. These findings calls for early detection of hypoglycaemia, prevention of hypothermia and early initiation of feeding to prevent neonatal morbidity and mortality.

show abstract

Neonatal Hypoglycemia: Risk Factors and Outcomes

Cited by 19 publications

References 27 publications

Clinico-biochemical profile of hypoglycemia in neonates admitted in NICU

Clinico-biochemical profile of hypoglycemia in neonates admitted in NICU

Glycemic status and its effect in Neonatal Sepsis - A prospective study in a Tertiary Care Hospital in Nepal

Prevalence and Risk factors of Hypoglycaemia in Neonates at St. Paul’s Hospital Millennium Medical College Neonatal Intensive Care Unit, Ethiopia: A Cross Sectional Study

Contact Info

Product

Resources

About