Neonatal Hypernatremic Dehydration and Thrombocytopenia: Its Prevalence and Relationship with Prognosis

Boskabadi, Hassan; Rakhshanizadeh, Forough

doi:10.5812/ijp.65742

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…In fact, more complications and poor prognosis were seen in patients with thrombocytopenia. 27 The cause of decreased platelet count among infants is unknown in our study. Nonetheless, dehydration, hypernatremia, and azotemia in these infants may have inhibitory effects on the bone marrow or may cause a state with excessive peripheral platelet consumption.…”

Section: Resultsmentioning

confidence: 66%

Comparison of the health status of exclusively breastfeeding infants and newborns receiving sugar water along with breast milk

Boskabadi¹,

Maamouri²,

Bagheri³

et al. 2020

Acta Pediatr Mex

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Section: Resultsmentioning

confidence: 66%

Comparison of the health status of exclusively breastfeeding infants and newborns receiving sugar water along with breast milk

Boskabadi¹,

Maamouri²,

Bagheri³

et al. 2020

Acta Pediatr Mex

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“…This was found to be significantly associated with the severity of hypernatremic dehydration, with thrombocytopenia being more severe in patients with severe hypernatremic dehydration. In a recent study by Boskabadi H et al, 21 thrombocytopenia was observed in 41% of patients with hypernatremia and 6% of isonatremic infants ( P < 0.05). Urea, creatinine, and blood glucose were higher in patients with hypernatremic dehydration with thrombocytopenia as compared with those with normal platelet count and hypernatremia.…”

Section: Discussionmentioning

confidence: 85%

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Tanwar,

Kapoor,

Kumar

et al. 2023

Pediatr Emer Care

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Objectives The aim of this study was to evaluate the clinical profile and outcome of young infants presenting to the pediatric emergency department with hypernatremic dehydration. Methods A prospective observational study was conducted at a tertiary care teaching hospital over a period of 18 months. All outborn sick young infants aged 2 months or younger who presented to the emergency department with symptoms and signs of possible sepsis and/or dehydration were screened, and those with hypernatremia were enrolled in the study. Those infants born at less than 37 weeks of gestation and gross congenital anomaly were excluded. Hypernatremic dehydration was defined as serum sodium levels (Se Na+)higher than 145 mEq/L. Variables used in the study were defined as per standard definitions. Acute kidney injury was defined and staged using serum creatinine as per modified neonatal Kidney Disease Improving Global Outcome guidelines. Clinical presentation, laboratory parameters, and comorbidities were compared among outcome groups (survived and died). Results Of 1124 outborn young infants who met the eligibility criteria for screening, 63 were diagnosed to have hypernatremic dehydration and 55 were enrolled. The hospital-based period prevalence of hypernatremic dehydration in young infants was 4.89%. The median age of presentation was 17 days (10–30). Male-to-female ratio was 1.1:1. Seventy-three percent were first in birth order. Feeding pattern showed 61.8%, 30.9%, and 7.3% of infants were exclusively breastfed, top fed, and mixed fed, respectively. The median serum sodium at the time of admission was 160 (153.5–167) mg/dL. Three (5.5%) infants had mild, 39 (70.9%) had moderate, and 13 (23.6%) had severe hypernatremic dehydration. There was statistically significant correlation between median platelet count with severity of hypernatremic dehydration. The mean time taken to correct serum sodium level was 3.30 ± 1.60 days. The case fatality rate was 41.8%. Those who died had statistically more severe hypernatremic dehydration, acute kidney injury, sepsis, and need for ventilation. Conclusions Acute kidney injury stage 3, shock, and need for ventilation are associated with poor outcome in infants with hypernatremic dehydration

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“…However, there was no correlation between thrombocyte levels and serum Na levels. On the other hand, Boskabadi et al (34) have demonstrated a strong correlation between hypernatremia and thrombocytopenia and a poorer prognosis and significantly more complications in thrombocytopenia patients. Babies born early term were found to have significantly lower serum sodium and glucose levels, higher antimicrobial usage rates, and a higher frequency of mixed feeding.…”

Section: Discussionmentioning

confidence: 98%

Retrospective analysis of 102 neonatal cases hospitalized with diagnosis of the ongoing phenomenon of neonatal period: hypernatremic dehydration

Özdil

Vardar

2023

Journal of Health Sciences and Medicine

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Aim: The aim of this study was to examine the prevalence of hypernatremic dehydration (HD) among term neonates admitted to a tertiary care unit over a three-year period and to identify mother and neonate related risk factors associated with HD. Material and Method: Medical records of 102 term babies and their mothers were analyzed retrospectively. The gender, weight at birth, type of birth, postnatal day of diagnosis, weight and weight loss percentage at diagnosis, season and presenting complaint upon admission, feeding with human milk/formula/mixed, laboratory findings, usage of antibiotics as well as maternal age, parity, residence, level of education and presence of smoking were recorded. Serum sodium (Na) levels, severity of dehydration, age on admission, and length of stay in the neonatal intensive care unit (NICU) were recorded along with any significant effect of maternal demographic properties, residence, season, gender, and type of birth. Results: The average Na levels were found to be 152.1±4.2 mEq/L (max:166 mEq/L). Mild, moderate and severe hypernatremia were found in 34 (33%), 62 (61%) and 6 (6%) patients, respectively. More weight loss was observed in neonates born via cesarean section vs. vaginal delivery (12.8±3.0% vs. 11.6±3.5%, p=0.01). Higher serum Na levels (153.9±4.86 mEq/L vs. 151±2.34 mEq/L, p=0.008) and a greater median age at admission (4.5 [IQR4-6]) days vs. 3 [IQR3-4]) days, p=0.03) were reported for neonates born to mothers residing in rural/suburban vs. urban areas. Serum Na levels were not different based on the mother's level of education or parity (p=0.96 and p=0.29, respectively). There was no difference in serum Na levels (p=0.05) but the percentage of weight loss was higher when the mother smoked (14.3±3.8% vs. 11.7±3.1%, p=0.003). Serum Na and glucose levels were lower, antibiotics usage rates, and prevalence of mixed feedings were higher in early term infants (p=0.01, p=0.002, p=0.04 and p=0.04, respectively). Males had higher creatinine levels (0.89±0.27 mg/dl vs. 0.78±0.28 mg/dl, p=0.005), but there was no difference between the sexes in terms of day of admission, percentage of weight loss, or length of stay in NICU. Conclusion: Hypernatremic dehydration is a significant and increasingly prevalent problem of neonatal period. Serum Na levels and severity of dehydration in neonates may be affected by the type of birth, mother's smoking status, residence and early term birth. Counseling on breastfeeding, education of health professionals and caregivers on the signs and symptoms of dehydration, and monitoring of body weight are essential for the prevention, diagnosis, and treatment of HD.

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Neonatal Hypernatremic Dehydration and Thrombocytopenia: Its Prevalence and Relationship with Prognosis

Cited by 4 publications

References 23 publications

Comparison of the health status of exclusively breastfeeding infants and newborns receiving sugar water along with breast milk

Comparison of the health status of exclusively breastfeeding infants and newborns receiving sugar water along with breast milk

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Retrospective analysis of 102 neonatal cases hospitalized with diagnosis of the ongoing phenomenon of neonatal period: hypernatremic dehydration

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