Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats

Krüger, Hanna-Sophie; Brockmann, Marco D.; Salamon, Johannes; Ittrich, Harald; Hanganu‐Opatz, Ileana L.

doi:10.1016/j.nlm.2012.04.001

Cited by 46 publications

(75 citation statements)

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“…Our observation that OiC task performance emerges by PD17 is similar to the emergence of standard object recognition (OR) [14-17], but not other forms of spatial recognition memory like the object location recognition (OL) task, which emerges between PD17 and PD21 [17], or the 2-object variant of the object-in-place (OiP) task, which emerges between PD24 and 31 [15]. A study by Krüger et al showed that not only is OR apparent during the preweanling period of development, but also OL and temporal order recognition (TOR) [16]. It should be noted that Krüger and colleagues used a within-subjects design that may have facilitated the early ontogeny of the OL task on PD16 and the TOR task on PD17.…”

Section: Discussionmentioning

confidence: 99%

“…The OL task and CPFE rely on conjunctive spatial processing [5, 8, 28] subserved by the hippocampal system, which has been proposed for the OiC task [5]. These claims are supported by research showing that reversibly inactivating, lesioning, or blocking plasticity in the hippocampus disrupts performance in the OL task [12, 13, 16, 20, 21, 48] and the CPFE [7, 22-24]. …”

Section: Discussionmentioning

confidence: 99%

“…Performance of the OR task emerges before postnatal day (PD) 17 in the rat [16, 17], whereas our lab demonstrated that the OL task, which relies on hippocampal function [12, 13, 16, 20, 21], emerges between PD17 and 21 [17]. Likewise, the CPFE, a form of contextual fear conditioning that also requires incidental context learning and the hippocampus [7, 22-24], ontogenetically emerges around the same time [7, 8, but see 25].…”

Section: Introductionmentioning

confidence: 99%

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Ontogeny of object-in-context recognition in the rat

Ramsaran

Westbrook

Stanton

2016

Behavioural Brain Research

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The object-in-context recognition (OiC) task [19] is a spontaneous exploration task that serves as an index of incidental contextual learning and memory. During the test phase, rats prefer to explore the object mismatched to the testing context based on previous object-context pairings experienced during training. The mechanisms of OiC memory have been explored in adult rats [12, 35]; however, little is known about its determinants during development. Thus, the present study examined the ontogeny of the OiC task in preweanling through adolescent rats. We demonstrate that postnatal day (PD) 17, 21, 26, and 31 rats can perform the OiC Task (Experiment 1) and that preference for the novel target is eliminated when rats are tested in an alternate context not encountered during training (Experiment 2). Lastly, we show that PD26 but not PD17 rats can perform the OiC task when the training contexts only differed by distal spatial cues (Experiment 3). These data demonstrate for the first time that PD17 rats can acquire and retain short-term OiC memory, which involves conjunctive learning of object and context information. However, we also provide evidence that preweanling rats’ ability to utilize certain aspects of a context (i.e., distal spatial cues) in the OiC task is not equivalent to that of their older counterparts. Implications for the development of contextual memory and its related neural substrates are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ontogeny of object-in-context recognition in the rat

Ramsaran

Westbrook

Stanton

2016

Behavioural Brain Research

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“…Group II agonists also have inconsistent effects on the working memory impairments observed following administration phencyclidine [33,38]. Thus, establishing the effects of group II mGluR agonists on the deficits in TM in rodent models of psychiatric disorders [39,40] will be an important direction for future research.…”

Section: Discussionmentioning

confidence: 99%

Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268

Lins¹,

Ballendine²,

Howland³

2014

Neuroscience Letters

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Temporal order memory refers to the ability to distinguish past experiences in the order that they occurred. Temporal order memory for objects is often tested in rodents using spontaneous object recognition paradigms. The circuitry mediating memory in these tests is distributed and involves ionotropic glutamate receptors in the perirhinal cortex and medial prefrontal cortex. It is unknown what role, if any, metabotropic glutamate receptors have in temporal order memory for objects. The present experiment examined the role of metabotropic glutamate receptors in temporal memory retrieval using the group II metabotropic glutamate receptor selective agonist LY379268. Rats were trained on a temporal memory test with three phases: two sample phases (60 min between them) in which rats explored two novel objects and a test phase (60 min after the second sample phase) which included a copy of each object previously encountered. Under these conditions, we confirmed that rats showed a significant exploratory preference for the object presented during the first sample phase. In a second experiment, we found that LY379268 (0.3, 1.0, or 3.0 mg/kg; i.p.; 30 min before the test phase) had no effect on temporal memory retrieval but dose-dependently reduced time spent exploring the objects. Our results show that enhancing mGluR2 activity under conditions when TM is intact does not influence memory retrieval.

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“…This has increased the interest in understanding how brain areas interact during early development (Grieve et al, 2008;Omidvarnia et al, 2014) and how the neurocognitive abnormalities arise from early adversities via altering early neuronal network activity (Krüger et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

Tokariev

Vanhatalo

Palva

2016

Clinical Neurophysiology

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Dense array EEG Connectivity Brain development h i g h l i g h t sAnalysis of brain connectivity from the neonatal EEG is strongly enhanced by adding the number of electrodes. Sensitivity and specificity of cortical synchrony estimates depend on the analysis montage; average and Laplacian montage have the best performance. The number of electrodes defines the optimal montage and it also sets the limits for the level of analytic details. a b s t r a c tObjective: To assess how the recording montage in the neonatal EEG influences the detection of cortical source signals and their phase interactions. Methods: Scalp EEG was simulated by forward modeling 20-200 simultaneously active sources covering the cortical surface of a realistic neonatal head model. We assessed systematically how the number of scalp electrodes (11-85), analysis montage, or the size of cortical sources affect the detection of cortical phase synchrony. Statistical metrics were developed for quantifying the resolution and reliability of the montages. Results: The findings converge to show that an increase in the number of recording electrodes leads to a systematic improvement in the detection of true cortical phase synchrony. While there is always a ceiling effect with respect to discernible cortical details, we show that the average and Laplacian montages exhibit superior specificity and sensitivity as compared to other conventional montages. Conclusions: Reliability in assessing true neonatal cortical synchrony is directly related to the choice of EEG recording and analysis configurations. Because of the high conductivity of the neonatal skull, the conventional neonatal EEG recordings are spatially far too sparse for pertinent studies, and this loss of information cannot be recovered by re-montaging during analysis. Significance: Future neonatal EEG studies will need prospective planning of recording configuration to allow analysis of spatial details required by each study question. Our findings also advice about the level of details in brain synchrony that can be studied with existing datasets or by using conventional EEG recordings.

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Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats

Cited by 46 publications

References 50 publications

Ontogeny of object-in-context recognition in the rat

Ontogeny of object-in-context recognition in the rat

Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268

Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage

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