Neonatal Herpes Simplex Virus Infection

James, Scott H.; Kimberlin, David W.

doi:10.1016/j.idc.2015.05.001

Cited by 111 publications

(124 citation statements)

References 41 publications

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“…The risk of neonatal HSV-2 acquisition is high in new HSV-2 infections acquired during pregnancy [3]. Seventy to ninety percent of infants with neonatal HSV-2 are born to women who seroconvert to HSV-2 during pregnancy [3,15]. In Uganda, the neonatal mortality rate is still high, at 26 per 1,000 live births [16].…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

Nakubulwa

Kaye

Bwanga

et al. 2016

J Infect Dev Ctries

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Introduction: Herpes simplex virus type 2 (HSV-2) acquired during pregnancy is associated with adverse outcomes such as perinatal HSV-2 transmission. HSV-2 seroconversion occurs within four weeks of HSV-2 acquisition. There was neither documented incidence nor risk factors for HSV-2 seroconversion during pregnancy in Uganda. The objective of this study was to determine the incidence and risk factors for HSV-2 seroconversion among pregnant women in Mulago Hospital, Uganda. Methodology: A prospective study of 200 consenting HSV-2-negative women between 26 and 28 weeks of gestation was done between November 2013 and October 2014. HSV-2 serostatus was determined using HerpeSelect HSV-2 enzyme-linked immunosorbent assay (ELISA). Interviewer-administered questionnaires were used to collect socio-demographic characteristics and sexual history. Human immunodeficiency virus (HIV) serostatus was obtained from antenatal records. A total of 191 women completed follow-up and repeat HSV-2 serology by 38 weeks. Negative binomial regression analysis was used to estimate risk ratios for risk factors for HSV-2 seroconversion. Results: Of 191 women, 15 (7.9%) seroconverted during pregnancy. Having multiple sexual partners, being in polygamous unions, and having HIV-positive serostatus were found to be risk factors for HSV-2 seroconversion. Conclusions: The incidence of HSV-2 seroconversion during pregnancy in Uganda was high. Multiple sexual partners, polygamy, and HIVpositive serostatus were risk factors for HSV-2 seroconversion during pregnancy. Strengthening health education on the avoidance of multiple sexual partners during pregnancy is paramount in prevention of HSV-2 seroconversion.

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Section: Introductionmentioning

confidence: 99%

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

Nakubulwa

Kaye

Bwanga

et al. 2016

J Infect Dev Ctries

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“…Los estudios serológicos no se recomiendan de forma rutinaria para fines de diagnóstico en las infecciones por VHS neonatal (98).…”

Section: Diagnósticounclassified

“…La muestra es positiva en la mayoría de los pacientes con infección por VHS neonatal, independientemente de su clasificación clínica y, por lo tanto, no debe utilizarse para determinar la extensión de la enfermedad o la duración apropiada del tratamiento (98,99,101). Esto es más relevante en el escenario de un lactante con enfermedad de piel, ojo y mucosas, en quienes la muestra en sangre también resultará positiva la mayoría de las veces.…”

Section: • Sangreunclassified

Síndrome de TORCH: Enfoque racional del diagnóstico y tratamiento pre y post natal.: Recomendaciones del Comité Consultivo de Infecciones Neonatales Sociedad Chilena de Infectología, 2016

Cofré

Delpiano

Labraña

et al. 2017

Rev. chil. obstet. ginecol.

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“…Herpes simplex virus -HSV1 and HSV2 -infections are highly prevalent worldwide and are characterized by establishing lifelong infection with periods of latency interspersed with periodic episodes of reactivation [29]. Only two individuals were HSV1 positive.…”

Section: Molecular Diagnosis Of Herpesvirus Familymentioning

confidence: 99%

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

Silva

Moniz

Pereirinha

et al. 2016

J Infect Dev Ctries

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Introduction: We performed a descriptive analysis of molecular diagnosis of infectious agents in the São Miguel Island population, in order to address questions like what is the frequency of clinical requests, is it observable seasonality of pathogens, and what is the positive rate for the clinical diagnosis. Methodology: This was a retrospective and descriptive study based on 878 individuals suspected of harboring infectious diseases during two consecutive years, 2012-2013. More than 25 different pathogens were investigated by polymerase chain reaction (PCR)-based methods. The individuals were stratified into gender, occupation, and age groups. Results: The pathogen with more clinical requests was hepatitis C virus, investigated in 225 individuals (30.0%), followed by Leptospira spp., in 187 (24.9%). Overall, data demonstrated a gender distribution bias, where 72.9% of cases were males. The age group of 25 to 44 years was the class with more clinical requests. Regarding occupation, a predominance of construction workers (12.0%) was observed, followed by retired workers (11.0%). Patient distribution per year showed a higher number of patients in the fall months. Diagnoses of leptospirosis and respiratory virus infections presented seasonality. Conclusions: The present study provides a valid contribution to the knowledge of the epidemiology of infectious diseases in the São Miguel Island (Azores, Portugal) population.

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Neonatal Herpes Simplex Virus Infection

Cited by 111 publications

References 41 publications

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

Síndrome de TORCH: Enfoque racional del diagnóstico y tratamiento pre y post natal.: Recomendaciones del Comité Consultivo de Infecciones Neonatales Sociedad Chilena de Infectología, 2016

Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital-based descriptive study

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