Neonatal Herpes Simplex Encephalitis

Rk, Sharma; Sharma, Shobha

doi:10.1016/s0377-1237(17)30608-1

Cited by 1 publication

(2 citation statements)

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“…Treatment: Intravenous acyclovir is currently the recommended drug for the treatment of HSV CNS infection in neonate and infant likely due to its minimal side effects. However, neonatal HSE can be well treated with Idoxirudine and Vidarabine which significantly reduced morbidity and mortality but has limited tolerability than acyclovir and treatment should be commenced early within two days of onset of neurological symptoms [ 36 , 37 , 47 ]. The recommended dose of acyclovir for the management is 10mg/kg/dose over 1hr as infusion 8hrly for 10-14days; however, some studies suggested high dose of acyclovir of 60mg/kg/day in 3 divided doses eight hourly but safety cannot be ascertained [ 3 , 36 , 37 ].…”

Section: Reviewmentioning

confidence: 99%

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Viral Infections of the Central Nervous System in Children: A Systematic Review

Abdullahi¹,

Sarmast²,

Jahan³

2020

Cureus

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Viral infections of the central nervous system such as meningitis, encephalitis or meningoencephalitis, are important causes of significant morbidities and mortality worldwide. Early diagnosis and prompt treatment will lead to better outcomes, but any delay may results in high fatality with serious neurologic sequelae among survivors. We conducted a systematic review of published literature on the clinical presentation, diagnosis, treatment and complications of viral infections of the central nervous system from 1980 to 2019 on four databases comprising of PubMed, PubMed Central, Google Scholar and Medline to give the current understanding for better patient management. This systematic review demonstrates the management approach of viral infections of the central nervous system in children from the point of clinical presentation, diagnosis, treatment and complications. Definitive treatment remained unknown; however, certain antiviral drugs were proved to be effective. Therefore, prevention through childhood vaccination is the best management option.

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Section: Reviewmentioning

confidence: 99%

“…Other acyclic nucleoside analogues such as valacyclovir and famciclovir have higher bioavailability than acyclovir and thus are used as oral regimens. The supportive measures for HSE include seizure control with anticonvulsant, adequate hydration as high-dose aciclovir can cause acute renal failure and adjunctive steroids [ 36 , 37 , 47 ].…”

Section: Reviewmentioning

confidence: 99%