Neonatal Hemostatic Disorders: Issues and Challenges

Hanmod, Santosh S.; Jesudas, Rohith; Kulkarni, Roshni; Chitlur, Meera

doi:10.1055/s-0036-1593415

Cited by 14 publications

(11 citation statements)

References 53 publications

(89 reference statements)

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“…Usually, acquired factors including use of a CVC, malignant diseases, obesity, infections, cardiopathy, and nephrotic syndrome can be found in the majority of cases of paediatric thrombosis [ 19 , 20 , 21 ]. Use of a CVC is the most common cause in newborns [ 22 , 23 , 24 , 25 ]. The occurrence of catheter-related thrombosis in newborns does not require the testing of hereditary thrombophilia [ 12 ].…”

Section: Risk Factorsmentioning

confidence: 99%

Venous Thromboembolism in Children: From Diagnosis to Management

Lassandro

Palmieri

Palladino

et al. 2020

IJERPH

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Venous thromboembolism (VTE) in children is a rare occurrence, although in recent decades we have seen an increase due to several factors, such as the rise in survival of subjects with chronic conditions, the use of catheters, and the increased sensitivity of diagnostic tools. Besides inherited thrombophilia, acquired conditions such as cardiovascular diseases, infections, chronic disorders, obesity and malignancy are also common risk factors for paediatric VTE. The treatment of paediatric VTE consists of the use of heparins and/or vitamin K antagonists to prevent dissemination, embolization, and secondary VTE. Randomized clinical trials of direct oral anticoagulants in paediatric VTE are ongoing, with the aim to improve the compliance and the care of patients. We reviewed the physiological and pathological mechanisms underlying paediatric thrombosis and updated the current diagnosis and treatment options.

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Section: Risk Factorsmentioning

confidence: 99%

Venous Thromboembolism in Children: From Diagnosis to Management

Lassandro

Palmieri

Palladino

et al. 2020

IJERPH

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“…[37], обнаружен риск возникновения тромбоза в неонатальный период в 9,2% случаев. При неонатальном тромбозе приобретенные факторы встречаются значительно чаще по сравнению с наслед ственными факторами [26,44]. У новорожден ных тромбоз, связанный с катетером, является редким, но представляет собой серьезную про блему.…”

Section: приобретенные факторы тромбофилии у детейunclassified

Thrombophilia in children: what and when is it necessary to test

Мельник¹

2018

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Специализированный медицинский центр «Оптима фарм», г. Киев, Украина УДК 616.12 074 В последние десятилетия отмечается увеличение заболеваемости венозным тромбоэмболизмом (ВТЭ) детей всех возрастных групп, а также его связь с наследственной тромбофилией, что приводит к повышению тромботических рисков. При исследовании наследственной тромбофилии наиболее распространенными тестами являются АТ III, протеин С, протеин S, фактор V Лейдена и мутация фактора II протромбина. Тестирование наследственных тромботических факторов риска должно быть индивидуализировано. Консультирование и ведение пациентов с ВТЭ и выявленными маркерами тромбофилии должен осуществлять опытный гематолог или специалист в области гемостаза. Ключевые слова: тромбофилия, дети, венозный тромбоэмболизм, фактор риска, лабораторные методы исследования.

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“…Monitoring of the coagulation system is essential for certain adult and pediatric patients who are at high risk for bleeding and thrombosis. 1,2 There are also specific populations of adult and pediatric patients in whom coagulation diagnostic testing is routinely performed. 3,4 Patients presenting with symptoms of thrombosis or bleeding respectively undergo screening with hypercoagulability or bleeding panel testing to identify specific coagulation defects that may predispose a patient to hemostatic disorders.…”

mentioning

confidence: 99%

Novel Coagulation Analyzers in Development: A Glimpse toward the Future of Microfluidics

Emani

2019

Semin Thromb Hemost

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Coagulation diagnostic testing in pediatric patients currently requires large volume blood sampling and is performed on analyzers that are not well-suited for multiplexed assays on a given sample. For patients who require serial testing at regular intervals, repetitive phlebotomy leads to iatrogenic anemia and need for blood transfusions. Over the past decade, novel microfluidic platforms have been developed that allow for complex multiplexed assays to be performed on small sample volumes, near patient, with high fidelity. In the next few years, these devices will be introduced into clinical trials, and offer the promise of reliable, rapid, multiplexed coagulation assays for pediatric patients who require coagulation diagnostic testing.

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Neonatal Hemostatic Disorders: Issues and Challenges

Cited by 14 publications

References 53 publications

Venous Thromboembolism in Children: From Diagnosis to Management

Venous Thromboembolism in Children: From Diagnosis to Management

Thrombophilia in children: what and when is it necessary to test

Novel Coagulation Analyzers in Development: A Glimpse toward the Future of Microfluidics

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