Neonatal Hemochromatosis Associated With Maternal Autoantibodies Against Ro/SS-A and La/SS-B Ribonucleoproteins

Hepatobiliary Disease in Neonatal Lupus: Prevalence and Clinical Characteristics in Cases Enrolled in a National Registry

“…[3][4][5][6][7][8][12][13][14] Although the small number of cases reported seems to indicate that hepatobiliary disease is uncommon, our clinical impression was that this is an underestimate of the prevalence of hepatobiliary involvement in NLE. The results of this study confirm that approximately 10% of cases of NLE have significant hepatobiliary involvement.…”

“…However, to our knowledge, only 2 such cases have been previously reported, 1 of which is also included in this article. 5,7 This study is subject to several caveats. First, in some cases, the child's NLE was diagnosed retrospectively.…”

“…However, although several hundred cases of NLE have been reported, there are only a handful of case reports of NLE hepatobiliary disease. [3][4][5][6][7][8] Thus, there is little information about the clinical features and prognosis of NLE hepatobiliary disease. The relatively low number of cases reported is surprising in view of the fact that in the series of approximately 40 cases seen by 1 of the authors, 5 had hepatobiliary disease in addition to typical cardiac or cutaneous NLE lesions (L.A.L., personal observation).…”

Neonatal haemochromatosis: report of a patient with favourable outcome

“…Haemochromatotic siderosis can noninvasively be identified with nuclear magnetic resonance imaging and has been used for diagnosis in three infants [6,13,18]. Our patient had a reduced signal intensity in liver, but due to artifacts evidence of pancreatic or myocardial siderosis could not be demonstrated.…”

“…A noninvasive approach using magnetic resonance imaging and ultrasonography has been employed for monitoring a pregnancy at risk; the newborn did not have NH after birth [6]. Fetal blood sampling with determination of ferritin, iron and transferrin may give additional information as hyperferritinaemia was identified in blood samples of fetuses proven to have NH [18].…”