Neonatal handling increases fear and aggression in lactating rats

Giovenardi, Márcia; Azevedo, Márcia Scherem de; Silva, Simone P. da; Hermel, Erica do Espirito Santo; Gomes, Cláudio; Lucion, Aldo Bolten

doi:10.1016/j.physbeh.2005.07.011

Cited by 13 publications

(8 citation statements)

References 37 publications

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“…Handling also decreases affiliative social behavior (e.g., allogrooming, sniffing) and increases non-affiliative behavior (e.g., aggression) during a social interaction test (Todeschin et al, 2009). Moreover, lactating rats that were handled in infancy show increases in aggressive behaviors against a male intruder (Giovenardi et al, 2005; Padoin et al, 2001), although not all studies reveal these changes (Boccia & Pedersen, 2001). Overall, these findings highlight the importance of the early-life environment for the development of behavioral systems that can modulate the way animals cope with social demands and opportunities.…”

Section: Neonatal Handling and Social Behaviormentioning

confidence: 99%

Neonatal handling: An overview of the positive and negative effects

Raineki

Lucion

Weinberg³

2014

Developmental Psychobiology

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As one of the first rodent models designed to investigate the effects of early-life experiences, the neonatal handling paradigm has helped us better understand how subtle changes in the infant environment can powerfully drive neurodevelopment of the immature brain in typical or atypical trajectories. Here, we review data from more than 50 years demonstrating the compelling effects of neonatal handling on behavior, physiology, and neural function across the lifespan. Moreover, we present data that challenge the classical view of neonatal handling as an animal model that results only in positive/beneficial outcomes. Indeed, the overall goal of this review is to offer the suggestion that the effects of early-life experiences—including neonatal handling—are nuanced rather than unidirectional. Both beneficial and negative outcomes may occur, depending on the parameters of testing, sex of the subject, and neurobehavioral system analyzed.

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Section: Neonatal Handling and Social Behaviormentioning

confidence: 99%

Neonatal handling: An overview of the positive and negative effects

Raineki

Lucion

Weinberg³

2014

Developmental Psychobiology

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“…Unlike the presumably aversive early-life experiences discussed above (including separation from the mother) that can increase females' postpartum anxiety, neither neonatal handling nor being reared in an overlapping litter negatively affects postpartum maternal behavior or the growth of the litter (Giovenardi et al, 2005;Uriarte et al, 2014). Interestingly, these early life…”

Section: Accepted Manuscriptmentioning

confidence: 95%

“…Giovenardi and co-workers (Giovenardi et al, 2005) observed that lactating female rats that had experienced handling as neonates (1 min of nonharmful manipulation per day for the first 10 days of life) exhibited increased fear-like behaviors in the presence of a cat (i.e., less locomotion and more freezing) compared to mothers that were not neonatally handled. Consistent with those findings, female rats raised in overlapped litters that interact not only with their mother and age-matched littermates, but also with older siblings (Uriarte et al, 2008), later show increased anxiety-like behavior in an plus maze during the postpartum period .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Affective changes during the postpartum period: Influences of genetic and experiential factors

Agrati

Lonstein

2016

Hormones and Behavior

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“…Therefore, it is highly unlikely that differential individual histories, e.g. manipulation of cubs during cage cleaning and associated changes in neural plasticity, biased our behavioral data (Giovenardi et al, 2005) (c.f. WinkelmannDuarte et al, 2007).…”

Section: Materials and Methods Animalsmentioning

confidence: 99%

Innate or learned acoustic recognition of avian predators in rodents?

Kindermann

Siemers

Fendt

2009

Journal of Experimental Biology

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SUMMARYCalls of avian predators potentially predict danger for murine rodents. Indeed, exposure of field-experienced rodents to owl calls induces defensive behavior suggesting that recognition of vocalizations of avian predators is innate. To address this hypothesis, we investigated whether laboratory-reared and predator-naive rodents (mice, gerbils, rats) express defensive behavior in response to calls of different avian predators but we observed no such defensive behavior. We then asked whether the calls of avian predators are faster or better learned as a danger-predicting cue than the calls of avian non-predators. All calls could be learned as danger-predicting cues, but we found no differences in the speed or strength of the learning. Taken together, our results suggest that there is no innate recognition of the calls of avian predators in murine rodents and that the recognition of the calls of avian predators observed in field-experienced rodents is acquired by learning.

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Neonatal handling increases fear and aggression in lactating rats

Cited by 13 publications

References 37 publications

Neonatal handling: An overview of the positive and negative effects

Neonatal handling: An overview of the positive and negative effects

Affective changes during the postpartum period: Influences of genetic and experiential factors

Innate or learned acoustic recognition of avian predators in rodents?

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