2018
DOI: 10.1101/247122
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Neonatal gut and respiratory microbiota: coordinated development through time and space

Abstract: 27 28Background: Postnatal development of the microbiota in early life influences immunity, 29 metabolism, neurodevelopment and long-term infant health. Microbiome development occurs at 30 multiple body sites, each with distinct community compositions and functions. Associations 31 between microbiota at multiple sites represent an unexplored influence on the infant 32 microbiome. Here, we examined co-occurrence patterns of gut and respiratory microbiota in 33 pre-and full-term infants over the first year of li… Show more

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Cited by 5 publications
(7 citation statements)
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References 76 publications
(73 reference statements)
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“…The normal physiology, metabolism, immunity, and neurological functions of animal bodies are regulated by microbiota. The colonization and development of microbiota is a complex process, from dynamic changes to gradual stabilization of internal and external factors (Grier et al, 2018). Our results of the taxonomic analysis of Sciellour et al, 2018;McCormack et al, 2017).…”
Section: Discussionmentioning
confidence: 81%
“…The normal physiology, metabolism, immunity, and neurological functions of animal bodies are regulated by microbiota. The colonization and development of microbiota is a complex process, from dynamic changes to gradual stabilization of internal and external factors (Grier et al, 2018). Our results of the taxonomic analysis of Sciellour et al, 2018;McCormack et al, 2017).…”
Section: Discussionmentioning
confidence: 81%
“…After sample collection, multiple aliquots of sterile saline with swabs used for sample collection were carried through our entire sequencing protocol as individual samples, including DNA extraction, 16S rRNA amplification, library construction and sequencing to monitor potential background microbiome [2]. Data from these background control samples is deposited in SRA along with positive controls.…”
Section: Microbiota Background Controlmentioning
confidence: 99%
“…The composition and function of host-associated microbial communities are associated 77 with many aspects of health and disease [1]. These relationships between the microbiome and 78 host biology exhibit spatial and temporal dependencies, with relevant interactions manifest by 79 the microbiota of specific body sites during critical periods of host development, environmental 80 exposure, pathogenesis, illness, or convalescence [2][3][4][5][6]. Specifically, there is a growing body of 81 evidence that the microbiome influences immune maturation and function [7][8][9], mucosal surface 82 physiology [10,11], and the risk and severity of acute and chronic respiratory diseases [12][13][14][15][16].…”
mentioning
confidence: 99%
“…The term "microbiota" refers to all microorganisms that live in the body, including bacteria, fungi, viruses, protozoa, and archaea, among others, and are found in large numbers and varying proportions (Koidl and Untersmayr, 2021). This ratio is dynamic during the first two years of life, after which it tends to balance, and early colonization of this "balanced" and "healthy" microbiota lays the groundwork for lifelong health (Grier et al, 2018). Although most current research has focused on the gut microbiota, the role of microbiota elsewhere in the body in human disease is becoming more recognized (Ver Heul et al, 2019).…”
Section: Introductionmentioning
confidence: 99%