Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats

Kubo, Taizo; Kohira, Ryutaro; Okano, Tadao; Ishikawa, Koichi

doi:10.1016/0006-8993(93)90223-a

Cited by 30 publications

(22 citation statements)

References 21 publications

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“…Accordingly, our findings suggest an impairment of hippocampus-dependent memory in both sexes of rats. Although some studies have demonstrated that neonatal injections of MSG affect learning and memory in both sexes of rodents (Berry et al 1974;Kubo et al 1993), our findings demonstrated that male rats appear to be more susceptible to memory impairment (recognition and location) induced by MSG exposure than female rats (location). Accordingly, it has been proposed that male rats are more sensitive to neonatal stress associated with injections of MSG (Dubovicky et al 1999;Chow et al 2013).…”

Section: P C O Araujo and Otherscontrasting

confidence: 85%

“…In this regard, a recent study demonstrated that the hippocampus is more sensitive to MSG neurotoxicity (Gudiño-Cabrera et al 2014). Moreover, hippocampal memory formation occurs mainly in the hippocampal CA1 region (Kandel et al 2014), and MSG administration has been shown to induce damage in this brain area (Kubo et al 1993; et al 2002). Accordingly, our findings suggest an impairment of hippocampus-dependent memory in both sexes of rats.…”

Section: P C O Araujo and Othersmentioning

confidence: 99%

“…It has been reported that the MSG administration-induced alteration in locomotor activity in animals becomes greater with age (Hlinák et al 2005), and it is known that locomotor activity is closely related to hippocampal deregulation (Cerbone & Sadile, 1994). In this context, MSG treatment causes destruction and morphological changes of the CA1 hippocampal structure, accompanied by neuronal loss in the cerebral cortex (Kubo et al 1993;Beas-Zárate et al 2002). Therefore, the locomotor alterations induced by MSG in male and female rats could be associated with hippocampal damage.…”

Section: P C O Araujo and Othersmentioning

confidence: 99%

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Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Araujo

Quines

Jardim

et al. 2017

Experimental Physiology

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Edited by: Michael White New Findings r What is the central question of this study?Monosodium glutamate causes cognitive impairment. Does resistance exercise improve the performance of rats treated with monosodium glutamate? r What is the main finding and its importance?Resistance exercise is effective against monosodium glutamate-induced memory impairment in male and female rats.Monosodium glutamate (MSG), a flavour enhancer in diets, causes cognitive impairment in rodents. Exercise has been reported to protect against impairment of memory in humans. In this study, we investigated whether resistance exercise improves the performance of male and female rats treated with MSG in tests of memory and motor co-ordination. Wistar rats received MSG [4 g (kg body weight) −1 day −1 , s.c.] from postnatal day 1 to 10. At postnatal day 60, the animals started a resistance exercise protocol in an 80 deg inclined vertical ladder apparatus and performed it during 7 weeks. Rats performed object recognition and location memory tests. Resistance exercise reduced impairment in motor co-ordination of male and female rats treated with MSG. Resistance exercise was effective against the decrease in exploratory preference in the long-term recognition memory for novel objects of male rats treated with MSG. In MSG-treated female rats, resistance exercise was effective against the decrease in exploratory preference in the novel object location test. The exploratory preference of female rats in the long-term recognition memory test was similar in all groups. The short-term memory was not altered by MSG or resistance exercise in male and female rats. This study demonstrates that MSG affected the memory of male and female rats in different ways. Resistance exercise was effective against the decrease in recognition for male rats and in location memory for female rats treated with MSG. This report demonstrates the beneficial effects of resistance exercise against the prejudice of motor condition and impairment of memory induced by MSG in male and female rats.

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Section: P C O Araujo and Otherscontrasting

confidence: 85%

Section: P C O Araujo and Othersmentioning

confidence: 99%

Section: P C O Araujo and Othersmentioning

confidence: 99%

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Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Araujo

Quines

Jardim

et al. 2017

Experimental Physiology

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“…Behavioral studies have also shown that exposure to excess glutamate during critical periods of brain development can produce prolonged alterations in behavior [121,122]. The treatment with glutamate during the early postnatal period in rats resulted in defects in adjusting to a new environment 21 and 60 days later, something commonly found in ASD [123].…”

Section: Effect Of Dietary Food Additive Excitotoxinsmentioning

confidence: 99%

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

Blaylock

Strunecká

2009

CMC

123

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Despite the great number of observations being made concerning cellular and the molecular dysfunctions associated with autism spectrum disorders (ASD), the basic central mechanism of these disorders has not been proposed in the major scientific literature. Our review brings evidence that most heterogeneous symptoms of ASD have a common set of events closely connected with dysregulation of glutamatergic neurotransmission in the brain with enhancement of excitatory receptor function by pro-inflammatory immune cytokines as the underlying mechanism. We suggest that environmental and dietary excitotoxins, mercury, fluoride, and aluminum can exacerbate the pathological and clinical problems by worsening excitotoxicity and by microglial priming. In addition, each has effects on cell signaling that can affect neurodevelopment and neuronal function. Our hypothesis opens the door to a number of new treatment modes, including the nutritional factors that naturally reduce excitotoxicity and brain inflammation.

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“…Though, there is still a lot of controversy on the neurotoxic effects of MSG, studies over 30 years revealed that scientists have used MSG to induce neurodegeneration in vivo and in vitro (Kubo and Kohira, 1993;Zhou, 2009). Monosodium glutamate (MSG) is a natural constituent of many proteinrich food items, though it has been reported to elicit neurotoxic effects due to its deleterious effects on the cerebellum of wistar albino rats at higher concentrations.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective potential of Aframomum melegueta extracts on brain of monosodium glutamate-treated wistar albino rats

Fasakin¹,

Fajobi²,

Oyedapo³

2017

J. Neurosci. Behav. Health

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The study evaluated the biochemical effects of methanolic seed extract of Aframomum melegueta (MEAM) on biochemical parameters of the brain of rats treated with monosodium glutamate (MSG) with a view to considering the possibility of using the plant as a remedy for the management of neurotoxic disorders. MEAM was prepared according to standard methods, phytochemically screened and followed by evaluation of its antioxidant and anti-inflammatory potentials as well as its biological activities. Phytochemical screening of the methanolic extract (ME) revealed the presence of alkaloids, cardiac glycosides, flavonoids, saponins, steroids, tannins and terpenoids. Administration of MSG (2 g/kg bwt) caused alterations in the levels of glutathione, nitric oxide, Vitamin C and E, as well as in the reduction of activities of enzymatic antioxidants. There were increases in the activities of brain marker enzymes, protein and peroxidation levels. Histopathological observations of brain sections revealed that MEAM protected the brain from glutamate-induced neurotoxicity. Conclusively, extract of A. melegueta elicited appreciable and potent neuroprotective potentials against neuro-degeneration caused by MSG oral administration, in a concentration dependent manner.

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Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats

Cited by 30 publications

References 21 publications

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

Neuroprotective potential of Aframomum melegueta extracts on brain of monosodium glutamate-treated wistar albino rats

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