Neonatal fat embolism and agglutination of intralipid.

Mughal, M Z; Robinson, M. J.; Duckworth, William

doi:10.1136/adc.59.11.1098

Cited by 14 publications

(5 citation statements)

References 7 publications

(1 reference statement)

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“…Two case reports of preterm infants with sepsis found evidence of in vivo lipid agglutination with increased serum concentrations of C-reactive protein. 18,19 The correlation of elevated C-reactive protein with lipid agglutination was studied by Levene et al 20,21 who found that large lipid globules can lodge in the lung, engorge pulmonary capillaries, and exacerbate ventilation-perfusion mismatches in the preterm lung.…”

Section: Discussionmentioning

confidence: 99%

Safety of High Volume Lipid Emulsion Infusion

Hiller¹,

Gregorio

Kelly³

et al. 2010

Regional Anesthesia and Pain Medicine

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Section: Discussionmentioning

confidence: 99%

Safety of High Volume Lipid Emulsion Infusion

Hiller¹,

Gregorio

Kelly³

et al. 2010

Regional Anesthesia and Pain Medicine

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“…Several mechanisms have been postulated to account for an association between IVL usage and CNLD. These include pulmonary vasoconstriction related to increased thromboxane generation (8), lipid peroxidation and free radical generation (13), impairment of pulmonary oxygen diffusion (14,15), precipitation of IVL in pulmonary capillaries following agglutination by C‐reactive protein (16,17), and septicemia, particularly with coagulase negative staphylococci (5), since there is an association between the use of intralipids and these septicemias (18).…”

Section: Discussionmentioning

confidence: 99%

Randomised Trial of Effect of Delayed Intravenous Lipid Administration on Chronic Lung Disease in Preterm Neonates

Alwaidh,

Bowden,

Shaw

et al. 1996

J. pediatr. gastroenterol. nutr.

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SummaryA recent sevenfold increase in the annual incidence of chronic neonatal lung disease (CNLD) on an intensive care unit was attributed to the early administration of intravenous lipid (IVL) in ventilated preterm neonates. When logistic regression was used to eliminate other confounding variables, early delivery of IVL was independently associated with an eight‐fold increase in the likelihood of CNLD. Consequently, we designed a prospective study to detect a halving of the incidence of CNLD by delaying IVL administration from 5 days (as is routine practice) to 14 days. Sixty‐four parenterally fed preterm neonates weighing <1,500 g at birth were randomised to receive IVL either on day 5 or day 14. Analysis was by intention to treat, since several infants in the latter group required no parenteral nutrition by day 14. Our results showed that the relative risk (95% confidence interval) of CNLD at 28 postnatal days was 1.15 (0.81‐1.62); at 36 weeks postconception, it was 1.08 (0.59‐1.99). A study population of >2,000 would be required to determine whether these relative risks were significantly different from 1.

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“…Recently, this syndrome was also described after bone surgery [4,5], bone marrow transplantation, severe skeletal metastasis with hypercalcaemia and bone necrosis after decompression sickness. Deposition of lipid globules can also be found after hysterography, after treatment of premature babies with intravenous intralipid [6], and after trauma of a fatty liver. Spontaneous resorption of the aggregates of fat usually occurs after several weeks.…”

Section: Discussionmentioning

confidence: 99%