Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development–modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat

Sotomayor‐Zárate, Ramón; Tiszavari, Michelle; Cruz, Gonzalo; Lara, Hernán E.

doi:10.1016/j.fertnstert.2011.09.011

Cited by 35 publications

(26 citation statements)

References 51 publications

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“…Pups were divided randomly into two groups of animals: control (n = 24) and EV (n = 24). The dose of EV used has been reported previously . All pups were raised with a nursing mother until weaning age (PND21).…”

Section: Methodsmentioning

confidence: 99%

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine‐induced conditioned place preference in adult female rats

Bonansco

Martínez-Pinto

Silva

et al. 2018

J Neuroendocrinology

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Steroid sex hormones produce physiological effects in reproductive tissues and also in nonreproductive tissues, such as the brain, particularly in cortical, limbic and midbrain areas. Dopamine (DA) neurones involved in processes such as prolactin secretion (tuberoinfundibular system), motor circuit regulation (nigrostriatal system) and driving of motivated behaviour (mesocorticolimbic system) are specially regulated by sex hormones. Indeed, sex hormones promote neurochemical and behavioural effects induced by drugs of abuse by tuning midbrain DA neurones in adult animals. However, the long-term effects induced by neonatal exposure to sex hormones on dopaminergic neurotransmission have not been fully studied. The present study aimed to determine whether a single neonatal exposure with oestradiol valerate (EV) results in a programming of dopaminergic neurotransmission in the nucleus accumbens (NAcc) of adult female rats. To answer this question, electrophysiological, neurochemical, cellular, molecular and behavioural techniques were used. The data show that frequency but not amplitude of the spontaneous excitatory postsynaptic current is significantly increased in NAcc medium spiny neurones of EV-treated rats. In addition, DA content and release are both increased in the NAcc of EV-treated rats, caused by an increased synthesis of this neurotransmitter. These results are functionally associated with a higher percentage of EV-treated rats conditioned to morphine, a drug of abuse, compared to controls. In conclusion, neonatal programming with oestradiol increases NAcc dopaminergic neurotransmission in adulthood, which may be associated with increased reinforcing effects of drugs of abuse.

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Section: Methodsmentioning

confidence: 99%

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine‐induced conditioned place preference in adult female rats

Bonansco

Martínez-Pinto

Silva

et al. 2018

J Neuroendocrinology

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show abstract

“…For example, testosterone treatment post-gonadectomy resulted in increased cholinergic cell count in the anterior cingulate cortex and increased cholinergic fiber density in the hippocampus (Nakamura et al, 2002). In contrast, administration of high doses of testosterone propionate have been associated with increased glutamatergic neurotoxicity and decreased cholinergic tone (Sotomayor-Zarate et al, 2011). Given the rapidly changing testosterone levels during development, it is unclear whether and over which age range testosterone would carry out neuroprotective vs. neurotoxic actions.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function

Nguyen

Lew

Albaugh

et al. 2017

Psychoneuroendocrinology

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Testosterone is thought to play a crucial role in mediating sexual differentiation of brain structures. Examinations of the cognitive effects of testosterone have also shown beneficial and potentially sex-specific effects on executive function and mnemonic processes. Yet these findings remain limited by an incomplete understanding of the critical timing and brain regions most affected by testosterone, the lack of documented links between testosterone-related structural brain changes and cognition, and the difficulty in distinguishing the effects of testosterone from those of related sex steroids such as of estradiol and dehydroepiandrosterone (DHEA). Here we examined associations between testosterone, cortico-hippocampal structural covariance, executive function (Behavior Rating Inventory of Executive Function) and verbal memory (California Verbal Learning Test-Children’s Version), in a longitudinal sample of typically developing children and adolescents 6–22 yo, controlling for the effects of estradiol, DHEA, pubertal stage, collection time, age, handedness, and total brain volume. We found prefrontal-hippocampal covariance to vary as a function of testosterone levels, but only in boys. Boys also showed a specific association between positive prefrontal-hippocampal covariance (as seen at higher testosterone levels) and lower performance on specific components of executive function (monitoring the action process and flexibly shifting between actions). We also found the association between testosterone and a specific aspect of executive function (monitoring) to be significantly mediated by prefrontal-hippocampal structural covariance. There were no significant associations between testosterone-related cortico-hippocampal covariance and verbal memory. Taken together, these findings highlight the developmental importance of testosterone in supporting sexual differentiation of the brain and sex-specific executive function.

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“…Exposure to excess androgens during fetal or prepubertal life may induce alterations in the ovary, such as polycystic ovary syndrome (Xita and Tsatsoulis, 2006), increased follicular recruitment (Steckler et al, 2005), and follicular persistence (Manikkam et al, 2006). Sotomayor-Zárate et al (2011) found that exposure to TP at a dose of 1 mg to female rats during the first 12 h of life reduced the number of ovarian follicles, increased cystic follicles, and produced absence of corpora lutea.…”

mentioning

confidence: 97%

Perinatal Androgenic Exposure and Reproductive Health Effects Female Rat Offspring

Guerra

Silva

Luchiari

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development–modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat

Cited by 35 publications

References 51 publications

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine‐induced conditioned place preference in adult female rats

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine‐induced conditioned place preference in adult female rats

Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function

Perinatal Androgenic Exposure and Reproductive Health Effects Female Rat Offspring

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