Neonatal exposure to naltrexone affects morphine sensitivity and facilitates sexual behaviour in female rats

Meyerson, Bengt J.; Berg, Marita

doi:10.1016/0304-3940(85)90569-5

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Secondly, the effects are not confined to sex-differentiated pathways and are simi lar in both sexes. Nevertheless, morphine exposure during the period of imprinting disturbs the sex-differentiated sexual behav iour in adult male rats [Vathy et al, 1985;Meyerson and Berg, 1985],…”

Section: Discussionmentioning

confidence: 99%

“…1983; Meyerson and Berg, 1985;Vathy et al, 1985], but also physiological [Lapointe and Nosal, 1982] and biochemical [Ward et al, 1983] parameters. The aim of the present study was to investigate whether morphine exposure during the period critical for the imprinting of sex-differentiated hepatic me tabolism would cause any changes in the adult metabolism of 4-androstene-3,17-dione and various drug substrates including morphine.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal Opiate Exposure - Effects on Metabolism of Xenobiotics and Steroids in Adult Rat Liver

Hansson

Näslund²,

Blanck³

et al. 1989

Dev Pharmacol Ther

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The effects of perinatal or neonatal morphine exposure on the hepatic steroid and xenobiotic metabolism in adult rats were studied. Early morphine exposure did not affect the 16α-hydroxylation or 5α-reduction of androstenedione in either sex, but decreased the 7α- and 6β-hydroxylations in both sexes. Morphine exerted a suppressive effect on the ethoxyresorufin-O-deethylase activity and increased the ethoxycoumarin-O-deethylase activity in both sexes. Morphine exposure did not significantly affect its own N-demethylation or the total cytochrome P-450 content in the liver. Neonatal morphine exposure caused a significant decrease in body and testes weight in the adult male rat. We conclude that the effects of morphine are not confined to sex-differentiated pathways and are similar in both sexes.

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Section: Discussionmentioning

confidence: 99%