Neonatal Erythrocyte Glutathione Peroxidase Deficiency as a Consequence of Selenium Imbalance during Pregnancy

Perona, G.; Guidi, Gian Cesare; Piga, Antonio; Cellerino, R; Milani, Gabriella; Colautti, P.; Moschini, G.; Stievano, B. M.

doi:10.1111/j.1365-2141.1979.tb01169.x

Cited by 51 publications

(12 citation statements)

References 16 publications

(8 reference statements)

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“…Furthermore, increased transfer of oxidized GSH due to membrane damage could be a reason for the decreased intracellular GSH. Some researchers have suggested that increases or decreases in the antioxidant levels occur during normal pregnancy [11,[23][24][25]. As in our study, Carine et al [11] and Zachara et al [24] observed no important difference in the GSH-P levels between pregnant women in the third trimester and nonpregnant women.…”

Section: Discussionsupporting

confidence: 65%

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Arikan

Konukoğlu

Arıkan

et al. 2001

Gynecol Obstet Invest

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The present study was undertaken to determine the change of blood lipid peroxide and antioxidant status in healthy nonpregnant women (n = 20), pregnant women in the third trimester (n = 20), pregnant women during delivery (n = 26) and fetal cord blood. Plasma and erythrocyte malondialdehyde (MDA) levels were found to be significantly higher and erythrocyte glutathione (GSH) levels were significantly lower in pregnant women in the third trimester than in nonpregnant women (p < 0.02, p < 0.03 and p < 0.001, respectively). The highest plasma and erythrocyte MDA levels and the lowest GSH levels were obtained from the pregnant women during delivery (6.99 ± 2.35 nmol/ml, 283.20 ± 43.81 nmol/g Hb, 6.73 ± 2.34 µmol/g Hb, respectively). Erythrocyte glutathione peroxidase (GSH-P) and glutathione reductase (GSH-R) activities were not different between the groups. Maternal plasma and erythrocyte MDA levels were significantly correlated with cord blood plasma and erythrocyte MDA levels (r = 0.63, p < 0.001, and r = 0.41, p < 0.001, respectively). There was a significant positive correlation in GSH-R and in GSH-P activities between maternal and cord blood erythrocytes (r = 0.81, p < 0.001, and r = 0.79, p < 0.001, respectively). A significant correlation was found between maternal erythrocyte GSH-P and both cord blood erythrocyte GSH-R activities (r = 0.74, p < 0.001) and cord erythrocyte GSH levels (r = 0.73, p < 0.001). There was also a significant negative correlation between maternal erythrocyte MDA and cord erythrocyte GSH-R levels (r = –0.9, p < 0.001). Our results suggest that lipid peroxidation and antioxidant status may be changed during delivery, and these changes may affect the fetus by creating oxidative stress.

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Section: Discussionsupporting

confidence: 65%

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Arikan

Konukoğlu

Arıkan

et al. 2001

Gynecol Obstet Invest

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“…Λ good agreement on Superoxide dismutase, catalase and glutathione peroxidase activities in pregnant women does not exist in previously published data (27)(28)(29)35), probably because the blood samples were not obtained at the same period of pregnancy. In the group of mothers we have studied, the blood samples were obtained at the beginning of labour, and the three enzymes were tested on the same sample.…”

Section: Discussionmentioning

confidence: 63%

“…Low activities of glutathione peroxidase in cord blood were previously reported by many authors (22)(23)(24)(25)(26)(27)(28) It is worth mentioning that no correlation was found between the levels of erythrocyte antioxidant enzymatic activities present in cord blood and the levels of bilirubin during the first days of life.…”

Section: Discussionmentioning

confidence: 67%

Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Maternal and Cord Blood Erythrocytes

Agostoni¹,

Gerli²,

Beretta³

et al. 1980

Clinical Chemistry and Laboratory Medicine

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Summary: The "antioxidant" enzymes Superoxide dismutase, catalase and glutathione peroxidase were assayed in a biological model with low oxygen tension (red cells from cord blood of newborn infants). Catalase and glutathione peroxidase activities in red cells of newborns were significantly lower when compared with their mothers and with normal controls. In contrast, Superoxide dismutase activity was unchanged. Thus, normal activities of Superoxide dismutase seem to be necessary in order to protect red blood cells from Superoxide radicals during foetal life, while even low activities of catalase and glutathione peroxidase are sufficient to protect red blood cells from hydrogen peroxide. No correlation was found between the "antioxidant" enzyme activities present in cord blood erythrocytes and the bilirubin concentrations during the first days of life. Nabelschnurblut-Erythrocyten Superoxiddismutase-, Katalase· und Glutathionperoxidase-Aktivitäten in mütterlichen und

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“…We have found that male newborn erythrocyte Se content is lower than females, and males also have lower plasma and GSHPx activity over the first 2 to 3 weeks of life. Others have also reported that males have lower newborn erythrocyte GSHPx activity 23,45,46 and plasma Se. 46 It is interesting to speculate whether this apparent lower Se status in male infants at birth, particularly as it appears to continue for first 2 to 3 weeks of life, contributes to the clearly higher morbidity and mortality evident in male infants.…”

Section: Discussionmentioning

confidence: 93%

Indicators of selenium status in Australian infants

Daniels

Gibson

Simmer

2000

J Paediatrics Child Health

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These data indicate that values for indicators of Se status of Australian infants and adults are at the lower end of the international range. This article highlights the paucity of Australian data on the Se content in the food supply and the Se status of the Australian population. Given the increasing range and complexity of the biological roles of Se and the emerging evidence that Se may have important roles in prevention of cancer and other disorders, further data are required to clarify the Se status of Australians.

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Neonatal Erythrocyte Glutathione Peroxidase Deficiency as a Consequence of Selenium Imbalance during Pregnancy

Cited by 51 publications

References 16 publications

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Maternal and Cord Blood Erythrocytes

Indicators of selenium status in Australian infants

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