Neonatal craniopharyngioma and inference of tumor inception time: case report and review of the literature

Arai, Toshinari; Ohno, Kikuo; Takada, Yoshiaki; Aoyagi, Masaki; Hirakawa, Kimiyoshi

doi:10.1016/s0090-3019(03)00204-0

Cited by 18 publications

(10 citation statements)

References 18 publications

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“…Notably, neonates with craniopharyngioma have poor prognosis independently of tumor therapy, with death being the usual outcome (248). With the exception of Bulow et al (243) and Pereira et al (216), who found that females had higher mortality, no gender differences have been confirmed (74,132,144,146,246).…”

Section: B Mortalitymentioning

confidence: 99%

Craniopharyngiomas

et al. 2006

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Craniopharyngiomas are rare, mainly sellar/parasellar, epithelial tumors diagnosed during childhood or adult life. Histologically, two primary subtypes have been recognized (adamantinomatous and papillary) with an as yet, unclarified pathogenesis. They may present with a variety of manifestations (neurological, visual, and hypothalamo-pituitary). Despite their benign histological appearance, they often show an unpredictable growth pattern, which, combined with the lack of randomized studies, poses significant difficulties in the establishment of an optimal therapeutic protocol. This should focus on the prevention of recurrence(s), improvement of survival, reduction of the significant disease and treatment-related morbidity (endocrine, visual, hypothalamic, neurobehavioral, and cognitive), and preservation of the quality of life. Currently, surgical excision followed by external beam irradiation, in cases of residual tumor, is the main treatment option. Intracystic irradiation or bleomycin, stereotactic radiosurgery, or radiotherapy and systemic chemotherapy are alternative approaches; their place in the management plan remains to be assessed in adequately powered long-term trials. Apart from the type of treatment, the identification of clinical and imaging parameters that will predict patients with a better prognosis is difficult. The central registration of patients with these challenging tumors may provide correlates between treatments and outcomes and establish prognostic factors at the pathological or molecular level that may further guide us in the future.

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Section: B Mortalitymentioning

confidence: 99%

Craniopharyngiomas

et al. 2006

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“…Although craniopharyngioma is a relatively common tumor of childhood, $10% of intracranial neoplasms, it seldom occurs before birth. [48][49][50][51][52][53][54][55][56][57][58][59] Because of its epithelial morphology and location intimately related to the pituitary gland, it is thought to arise from Rathke's pouch, an ectodermal diverticulum developing from the roof of the mouth. 29,30 Craniopharyngioma was third in frequency following teratoma and astrocytoma in this review (Tables 1 and 5).…”

Section: Craniopharyngiomamentioning

confidence: 99%

“…Life-threatening electrolyte disturbances resulting from pituitary insufficiency, which is noted particularly in this age group, is a common problem in the intra-and postoperative care of patients with this tumor. 55,56,59 However, with current neurosurgical techniques and improved postoperative care, the survival rate has improved somewhat. 55,56 Primitive Neuroectodermal Tumor The term ''primitive neuroectodermal tumor'' (PNET) is applied to a group of small, blue-cell malignant tumors of the central and peripheral nervous systems and soft tissues.…”

Section: Craniopharyngiomamentioning

confidence: 99%

Fetal Brain Tumors: A Review of 154 Cases

Isaacs

2009

Amer J Perinatol

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The purpose of this literature review is to describe the various types of brain tumors that occur in the fetus, their locations, initial findings, pathology, and outcome. Data are presented that show which patients are likely to survive or benefit from treatment compared with those who are unlikely to respond. An analysis is performed on patients with fetal brain tumors that were detected prenatally by imaging studies or discovered directly after birth. The review revealed 154 fetuses presenting with brain tumors. Teratoma was the leading neoplasm. Next was astrocytoma followed by craniopharyngioma, primitive neuroectodermal tumor, choroid plexus papilloma, meningeal tumors, and ependymoma. The most common presenting findings were macrocephaly and an intracranial mass. Overall hydrocephalus was next, followed by stillbirth. Most tumors were detected during the third trimester of pregnancy. Over a third of the affected fetuses were stillborn. Many tumors were inoperable as they occupied much of the intracranial cavity and involved large areas of the brain. Overall survival rate was 23/154, or 15%. Generally fetal brain tumors are associated with a poor prognosis.

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“…Prior to the current case, 9 cases of congenital CP had been described in utero. The clinical features and outcomes of all 10 cases are summarized in Table 1 [2][3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%