Neonatal Circumcision

Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates

“…It has also been reported that oral sucrose via a nipple is effective for pain relief in neonatal circumcision. 11 We consider, however, that this analgesic effect may be essentially due to the pacifier more than to sucrose itself.…”

“…The analgesic effects of sucrose have been reported in term and preterm newborn infants 7 – 11. Glucose and non-sucrose sweet tasting solutions have also been found to have analgesic effects 12 – 14…”

Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase

“…Human studies have produced similar observations. Consumption of a sucrose solution alleviated pain reactions and decreased crying after painful procedures in newborns (Blass and Hoffmeyer, 1991;Smith et al, 1992;Blass and Shide, 1994;Smith and Blass, 1996;Herschel et al, 1998;Overgaard and Knudsen, 1999). In children (Miller et al, 1994) and adult male subjects (Kakeda et al, 2008), sweet substances increased pain threshold, whereas a number of other works have observed that in adults the intake of palatable foods may have analgesic properties (Miller et al, 1994;Mercer and Holder, 1997;Lewkowski et al, 2003).…”