Neonatal Chikungunya Encephalopathy

Kumar, Surendra; Poonia, Anil K.; Agrawal, Karnika

doi:10.7199/ped.oncall.2019.22

Cited by 2 publications

(4 citation statements)

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“…Most studies (n = 35; 83,3%) were case reports and case series [ 9 , 16 – 21 , 23 – 42 , 45 – 49 , 51 – 53 ]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [ 9 , 10 , 16 – 21 , 23 , 25 , 27 , 49 – 51 ]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies [ 9 , 50 , 54 ].…”

Section: - Resultsmentioning

confidence: 99%

“…Most studies (n = 35; 83,3%) were case reports and case series [9,[16][17][18][19][20][21][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][45][46][47][48][49][51][52][53]. The clinical and perinatal manifestations of pregnancy and the outcome of gestation were described in ten studies [9,10,[16][17][18][19][20][21]23,25,27,[49][50][51]. Stillbirths and miscarriage associated with CHIKV vertical transmission with laboratory evidence were reported in three studies …”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

“…All included studies (n = 42) reported CHIKV vertical transmission confirmed by laboratory and clinical-epidemiological evidence in pregnant women (Table 1). The maternal infection diagnosis was confirmed by molecular and serological tests in 31 (73.8%) studies [6,9,10,[16][17][18][19][20][21][22][23][24][25][26][27][28]30,31,[33][34][35]39,41,[43][44][45][47][48][49][50][51]53,54] and in 243 (96.8%) women.…”

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed), LILACS, Web of Science, Scielo, Google Scholar and Open grey to identify studies assessing vertical transmission of CHIKV up to November 3, 2020. There were no search restrictions regarding the study type, the publication date or language. Studies with no documented evidence of CHIKV infection in neonates (negative RT-PCR or absence of IgM) were excluded. Results From the 227 studies initially identified, 42 were selected as follows: 28 case reports, 7 case series, 2 cross-sectional studies and 5 cohort studies, for a total of 266 CHIKV infected neonates confirmed by serological and/or molecular tests. The vertical transmission rate was 50% in the Reunion Island outbreak, which was the subject of the majority of the studies; the premature delivery were reported in 19 (45.2%) studies; the rate of fetal distress was 19.6% of infected babies and fetal loss occurred in 2% of the cases. Approximately 68.7% of newborns were diagnosed with encephalopathy or encephalitis after perinatally acquired CHIKV. Most of the infected neonates were born healthy, developing CHIKV sepsis clinical syndrome within the first week of life. Conclusions We alert neonatologists to the late manifestations of neonatal CHIKV infection, relevant to the management and reduction of morbidity. A limitation of our review was that it was not possible to carry out meta-analysis due to differences in study design and the small number of participants.

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Section: - Resultsmentioning

confidence: 99%

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Section: Pregnancy Outcome Clinical and Perinatal Characteristics Of The Pregnant Women (Table 2)mentioning

confidence: 99%

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Vertical transmission of chikungunya virus: A systematic review

et al. 2021

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“… 20 In newborns, symptoms tend to occur between 3 and 7 days of age, ranging from mild (43%) to severe clinical presentation, with viral encephalitis (53%) requiring intensive neonatal treatment. 25 The most commonly observed symptoms in this age group are fever, irritability, hyperalgesia, limb edema, rash, meningoencephalitis, 26 and clinical that are similar to neonatal sepsis. 20 The estimated lethality in newborns is around 2.8% and long-term neurodevelopmental involvement may occur in 50% of symptomatic cases.…”

Section: Chikungunyamentioning

confidence: 99%