Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very‐low‐birthweight preterm children

Rose, Jessica; Butler, Erin E.; LaMont, Lauren E.; Barnes, Patrick D.; Atlas, Scott W.; Stevenson, David K.

doi:10.1111/j.1469-8749.2008.03231.x

Cited by 119 publications

(121 citation statements)

References 32 publications

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“…Limited data suggest quantifiable sex differences in CC development at near-term age (4,34). Male gender is associated with increased risk of adverse outcomes, including CP, following preterm birth (35), although males and females did not differ in neurodevelopmental outcome in this study.…”

Section: Corpus Callosumcontrasting

confidence: 62%

“…Prior studies suggested DTI as a more sensitive biomarker than structural MRI for later neurodevelopment (4,11,27). Semi-automated, atlas-based DTI analysis has potential for clinical implementation because of its relative efficiency and repeatability.…”

Section: Near-term Dti and Neurodevelopment At 18-22 Momentioning

confidence: 99%

“…The PLIC includes motor fibers of the corticospinal tract and is undergoing myelination during the near-term period (36). The corticospinal tract descends through the posterior third of the PLIC, and analyses of the PLIC on DTI at near-term age suggests that it may hold prognostic value for future motor development (4,11).…”

Section: Internal Capsulementioning

confidence: 99%

“…a dvances in neonatal medicine have increased survival rates and improved outcome among very-low-birthweight (VLBW) preterm infants (1), but the incidence of neurodevelopmental impairment remains 3-4 times that of infants born full-term (2)(3)(4)(5). Motor, cognitive, and behavioral impairments are difficult to predict accurately at an early age, limiting our ability to identify at-risk infants who could benefit from intervention during critical periods of development.…”

mentioning

confidence: 99%

“…In the neonate, WM FA generally increases and MD decreases with age, likely due to increased fiber organization, axonal coherence, and preliminary myelination (11,16). Analysis of near-term regional WM development using DTI may provide prognostic information and help guide early treatment in children born preterm (4,17).…”

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confidence: 99%

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Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

et al. 2015

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Background: Near-term brain structure was examined in preterm infants in relation to neurodevelopment. We hypothesized that near-term macrostructural brain abnormalities identified using conventional magnetic resonance imaging (MRI), and white matter (WM) microstructure detected using diffusion tensor imaging (DTI), would correlate with lower cognitive and motor development and slower, less-stable gait at 18-22 mo of age. Methods: One hundred and two very-low-birth-weight preterm infants (≤1,500 g birth weight; ≤32 wk gestational age) were recruited prior to routine near-term brain MRI at 36.6 ± 1.8 wk postmenstrual age. Cerebellar and WM macrostructure was assessed on conventional structural MRI. DTI was obtained in 66 out of 102 and WM microstructure was assessed using fractional anisotropy and mean diffusivity (MD) in six subcortical brain regions defined by DiffeoMap neonatal atlas. Neurodevelopment was assessed with Bayley-Scales-of-InfantToddler-Development, 3rd-Edition (BSID-III); gait was assessed using an instrumented mat. results: Neonates with cerebellar abnormalities identified using MRI demonstrated lower mean BSID-III cognitive composite scores (89.0 ± 10.1 vs. 97.8 ± 12.4; P = 0.002) at 18-22 mo. Neonates with higher DTI-derived left posterior limb of internal capsule (PLIC) MD demonstrated lower cognitive and motor composite scores (r = −0.368; P = 0.004; r = −0.354; P = 0.006) at 18-22 mo; neonates with higher genu MD demonstrated slower gait velocity (r = −0.374; P = 0.007). Multivariate linear regression significantly predicted cognitive (adjusted r 2 = 0.247; P = 0.002) and motor score (adjusted r 2 = 0.131; P = 0.017). conclusion: Near-term cerebellar macrostructure and PLIC and genu microstructure were predictive of early neurodevelopment and gait.

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Section: Corpus Callosumcontrasting

confidence: 62%

Section: Near-term Dti and Neurodevelopment At 18-22 Momentioning

confidence: 99%

Section: Internal Capsulementioning

confidence: 99%

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confidence: 99%

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Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

et al. 2015

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Motor Development in Very Preterm and Very Low-Birth-Weight Children From Birth to Adolescence

Kieviet¹,

Piek²,

Aarnoudse-Moens³

et al. 2009

JAMA

430

268

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, van der Boechorststraat 1, 1081 BT Amsterdam, the Netherlands (jf.de.kieviet@psy .vu.nl). Context Infants who are very preterm (born Յ32 weeks of gestation) and very low birth weight (VLBW) (weighing Յ1500 g) are at risk for poor developmental outcomes. There is increasing evidence that very preterm birth and VLBW have a considerable effect on motor development, although findings are inconsistent. Objective To investigate the relationship between very preterm birth and VLBW and motor development. Data Sources The computerized databases EMBASE, PubMed, and Web of Knowledge were used to search for English-language peer-reviewed articles published between January 1992 and August 2009. Study Selection Studies were included if they reported motor scores of very preterm and VLBW children without congenital anomalies using 1 of 3 established and widely used motor tests: the Bayley Scales of Infant Development II (BSID-II), the Movement Assessment Battery for Children (MABC), and the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP). Forty-one articles were identified, encompassing 9653 children. Results In comparison with term-born peers, very preterm and VLBW children obtained significantly lower scores on all 3 motor tests: BSID-II: d=−0.88

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Association of Brain Microstructure and Functional Connectivity With Cognitive Outcomes and Postnatal Growth Among Early School–Aged Children Born With Extremely Low Birth Weight

Kim

Song

et al. 2023

JAMA Netw Open

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ImportancePostnatal growth may be associated with longitudinal brain development in children born preterm.ObjectiveTo compare brain microstructure and functional connectivity strength with cognitive outcomes in association with postnatal growth among early school–aged children born preterm with extremely low birth weight.Design, Setting, and ParticipantsThis single-center cohort study prospectively enrolled 38 children 6 to 8 years of age born preterm with extremely low birth weight: 21 with postnatal growth failure (PGF) and 17 without PGF. Children were enrolled, past records were retrospectively reviewed, and imaging data and cognitive assessments occurred from April 29, 2013, through February 14, 2017. Image processing and statistical analyses were conducted through November 2021.ExposurePostnatal growth failure in the early neonatal period.Main Outcomes and MeasuresDiffusion tensor images and resting-state functional magnetic resonance images were analyzed. Cognitive skills were tested using the Wechsler Intelligence Scale; executive function was assessed based on a composite score calculated from the synthetic composite of the Children’s Color Trails Test, STROOP Color and Word Test, and Wisconsin Card Sorting Test; attention function was evaluated using the Advanced Test of Attention (ATA); and the Hollingshead Four Factor Index of Social Status–Child was estimated.ResultsTwenty-one children born preterm with PGF (14 girls [66.7%]), 17 children born preterm without PGF (6 girls [35.3%]), and 44 children born full term (24 girls [54.5%]) were recruited. Attention function was less favorable in children with PGF than those without PGF (mean [SD] ATA score: children with PGF, 63.5 [9.4]; children without PGF, 55.7 [8.0]; P = .008). Significantly lower mean (SD) fractional anisotropy in the forceps major of the corpus callosum (0.498 [0.067] vs 0.558 [0.044] vs 0.570 [0.038]) and higher mean (SD) mean diffusivity in the left superior longitudinal fasciculus–parietal bundle (8.312 [0.318] vs 7.902 [0.455] vs 8.083 [0.393]; originally calculated as millimeter squared per second and rescaled 10 000 times as mean diffusivity × 10 000) were seen among children with PGF compared with children without PGF and controls, respectively. Decreased resting-state functional connectivity strength was observed in the children with PGF. The mean diffusivity of the forceps major of the corpus callosum significantly correlated with the attention measures (r = 0.225; P = .047). Functional connectivity strength between the left superior lateral occipital cortex and both superior parietal lobules correlated with cognitive outcomes of intelligence (right superior parietal lobule, r = 0.262; P = .02; and left superior parietal lobule, r = 0.286; P = .01) and executive function (right superior parietal lobule, r = 0.367; P = .002; and left superior parietal lobule, r = 0.324; P = .007). The ATA score was positively correlated with functional connectivity strength between the precuneus and anterior division of the cingulate gyrus (r = 0.225; P = .048); however, it was negatively correlated with functional connectivity strength between the posterior cingulate gyrus and both superior parietal lobules (the right superior parietal lobule [r = −0.269; P = .02] and the left superior parietal lobule [r = −0.338; P = .002]).Conclusions and RelevanceThis cohort study suggests that the forceps major of the corpus callosum and the superior parietal lobule were vulnerable regions in preterm infants. Preterm birth and suboptimal postnatal growth could have negative associations with brain maturation, including altered microstructure and functional connectivity. Postnatal growth may be associated with differences in long-term neurodevelopment among children born preterm.

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Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very‐low‐birthweight preterm children

Cited by 119 publications

References 32 publications

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

Motor Development in Very Preterm and Very Low-Birth-Weight Children From Birth to Adolescence

Association of Brain Microstructure and Functional Connectivity With Cognitive Outcomes and Postnatal Growth Among Early School–Aged Children Born With Extremely Low Birth Weight

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