Neonatal Blue-Light Phototherapy Does Not Increase Nevus Count in 9-Year-Old Children

Mahé, E.; Beauchet, Alain; Aegerter, Philippe; Saïag, Philippe

doi:10.1542/peds.2008-2986

Cited by 28 publications

(30 citation statements)

References 23 publications

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“…We confirmed the importance of pale phototype characteristics and the history of sunburn, but not of neonatal blue-light phototherapy on the early development of MN (Mahé et al, 2009). Hereafter, we report the impact of parental sun protection behaviors and sun exposure (in both parents and children) on MN count in their offspring.…”

Section: Introductionsupporting

confidence: 71%

“…Obviously, public awareness campaigns influence the latter only (Gallagher et al, 1990;English and Armstrong, 1994;Wiecker et al, 2003;Whiteman et al, 2005Whiteman et al, , 2008Mahé et al, 2009;Quéreux et al, 2009). This is one of the action points of the World Health Organization, which considers that 'prevention efforts should focus on this critical age group and work towards changing children's knowledge, attitudes and behavior in relation to sun protection ' (Rehfüss and von Ehrenstein, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…This is one of the action points of the World Health Organization, which considers that 'prevention efforts should focus on this critical age group and work towards changing children's knowledge, attitudes and behavior in relation to sun protection ' (Rehfüss and von Ehrenstein, 2002). Some risk factors for MN development are still controversial, such as the role of intermittent and/or cumulative sun exposure (Wiecker et al, 2003;Whiteman et al, 2005;Dodd et al, 2007), neonatal blue-light phototherapy (Mahé et al, 2009), and the use of a sunscreen (Autier et al, 1998;Gallagher et al, 2000;Bauer et al, 2005a). Parents also seem to play an important role in the development of MN in their children.…”

Section: Introductionmentioning

confidence: 99%

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Parents' attitudes related to melanocytic nevus count in children

Maleissye

Beauchet²,

Aegerter³

et al. 2010

European Journal of Cancer Prevention

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Sun exposure, fair phototype, and a high common melanocytic nevus (MN) count have been identified as the most important risk factors for melanoma. MN are mainly acquired during childhood, and their relationship to sun exposure, sunburn, and light skin complexion is well documented. The purpose of this study was to investigate how the sun protection attitudes of parents and their offspring affect MN development in children. We designed a cross-sectional study in 828 9-year-old school children. Trained nurses counted the MN on each child's back and arms, depending on their size. Questionnaires filled by children and parents provided information about sun exposure, attitude towards the sun, and sun-protection behaviors. Multivariate analysis showed that the childhood MN count was linked to fair phenotype--fair skin: rate ratio (RR)=3.80, 95% confidence interval (CI)=2.25-6.41; blue/green eyes: RR=1.2, 95% CI=1.11-1.34; blond hair: RR=1.25, 95% CI=1.10-1.41; history of sunburn: RR=1.13, 95% CI=1.03-1.23, seaside sun exposure--RR=1.14, 95% CI=1.01-1.28, and to their parents' behaviors during exposure to the sun--increase in the number of MN when parents used sunscreen: RR=1.23, 95% CI=1.08-1.40; decrease in MN count when parents wore a tee-shirt: RR=0.86, 95% CI=0.79-0.93. In conclusion, fair phenotype and sun exposure are known major risk factors for MN. Parents' behaviors influence their children and appeared in our analysis as another determinant predictor of MN count, being protective against (wearing a tee-shirt when exposed to sun) or increasing the risk (sunscreen use, reflecting higher sun exposure) for childhood MN development.

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Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parents' attitudes related to melanocytic nevus count in children

Maleissye

Beauchet²,

Aegerter³

et al. 2010

European Journal of Cancer Prevention

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“…There are several studies assessing the risk of developing moles in children 8-9 years after receiving neonatal blue light phototherapy for jaundice treatment [20,21,22]. Some of these studies find an association of naevus count with phototherapy, some do not.…”

Section: Discussionmentioning

confidence: 99%

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Pfaff

Liebmann²,

Born³

et al. 2015

Dermatology

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Background: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. Objective: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. Methods: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm², n = 24) and low-intensity treatment (LI: 453 nm LED, 100 mW/cm², n = 23) of one Pv plaque for 12 weeks. A contralateral control plaque remained untreated. Results: Patient compliance and satisfaction were high. The primary endpoint, change from baseline (CfB) of the Local Psoriasis Severity Index, revealed a significant improvement of the target compared to the control plaques (ΔCfB for the HI group: -0.92 ± 1.10, p = 0.0005; for the LI group: -0.74 ± 1.18, p = 0.0064). Conclusion: UV-free blue light home treatment is safe and improves Pv plaques.

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“…Os poucos trabalhos existentes, que procuram correlacionar o uso da fototerapia no período neonatal e o surgimento de maior número de nevos melanocíticos ou displásicos ao longo da vida, apresentam resultados controversos [24][25][26][27][28] .…”

Section: Nevos Melanocíticos Na Infância E Fototerapia No Período Neounclassified

Topical photoprotection in childhood and adolescence

2012

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Objective: Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood through inadequate sun exposure. This review aims to guide pediatricians on appropriate measures of topical photoprotection in children and adolescents, which will positively change the future of these patients. Sources:A review of the literature indexed in MEDLINE/PubMed between the years 1999 and 2012 on photoprotection in childhood was conducted. The most relevant review articles on photoprotection in children and adolescents, photoprotection and vitamin D in neonatal phototherapy and impact on skin cancer, artificial tanning and skin cancer were selected as sources. Summary of the findings:Children and adolescents should adopt appropriate measures of photoprotection in order to decrease the risk of melanoma and non-melanoma skin cancer. Conclusions:There are published data that support the association between sun exposure habits and safe use of topical sunscreens in children and adolescents on the one hand and a reduced occurrence of skin cancer on the other. ResumoObjetivo: A exposição à luz solar na infância ocorre, frequentemente, de forma mais intensa do que em muitos adultos. Dados da literatura comprovam de maneira inequívoca a associação desse comportamento social com o risco de desenvolvimento do melanoma maligno e do câncer cutâneo não melanoma mesmo na vida adulta. Além disso, o fotoenvelhecimento cutâneo é semeado já na infância com a exposição solar inadequada. Esta revisão tem como objetivo orientar os pediatras nas medidas adequadas de fotoproteção tópica nas crianças e adolescentes, o que irá alterar de maneira positiva o futuro desses pacientes. Fontes dos dados:Realizou-se uma revisão da literatura indexada na base de dados MEDLINE/PubMed entre os anos de 1999 e 2012 sobre fotoproteção na infância, selecionando-se como fonte os artigos de revisão mais relevantes, do ponto de vista de abrangência do tema fotoproteção em crianças e adolescentes, fotoproteção e vitamina D, fototerapia na neonatologia e impacto no câncer cutâneo, bronzeamento artificial e câncer cutâneo. Síntese dos dados:Crianças e adolescentes devem adotar medidas adequadas de fotoproteção para diminuir o risco de câncer cutâneo melanoma e não melanoma. Conclusões:Há dados na literatura que suportam a associação de hábitos de exposição solar segura e uso de fotoprotetores tópicos em crianças e adolescentes com a redução da ocorrência do câncer cutâneo.J Pediatr (Rio J). 2012;88(3):203-10: Melanoma maligno, câncer cutâneo, fotoproteção.

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Neonatal Blue-Light Phototherapy Does Not Increase Nevus Count in 9-Year-Old Children

Abstract: This study found no evidence for a major role of blue-light phototherapy on nevus count in 9-year-old children. It underlines the dominant effect of phototype characteristics and history of sunburn in childhood on the early development of melanocytic nevi.

Cited by 28 publications

References 23 publications

Parents' attitudes related to melanocytic nevus count in children

Parents' attitudes related to melanocytic nevus count in children

Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

Topical photoprotection in childhood and adolescence

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