Neonatal Blue-Light Phototherapy Could Increase the Risk of Dysplastic Nevus Development

Csoma, Zsanett; Hencz, P; Orvos, Hajnalka; Kemény, Lajos; Dobozy, A.; Dósa-Rácz, Éva Viharosné; Erdei, Zsuzsanna; Bartusek, Dóra; Oláh, Judit

doi:10.1542/peds.2007-0180

Cited by 31 publications

(23 citation statements)

References 5 publications

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“…Reported cutaneous side effects include transient rashes and the uncommon bronze baby syndrome, and a more hazardous side effect is ultraviolet burn [16]. Recent study suggested that intensive phototherapy might increase the number of atypical melanocytic nevi identified at school age [17]. The potential of phototherapy to damage DNA based on animal or cell-culture studies have been described, and one study suggests that phototherapy increases DNA damage also in human newborns [18].…”

Section: Discussionmentioning

confidence: 99%

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Percentile analysis of plasma total bilirubin—How different will the rate of phototherapy for jaundice of neonates be by different standards?

Nagao¹,

Watanabe²,

Yokota³

2012

OJPed

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Phototherapy of a jaundiced neonate is usually started when bilirubin exceeds a threshold in the standard. There are several standards used in the developed countries even though the guideline of American Academy of Pediatrics is considered to be a global standard. Although the purpose of phototherapy is the prevention of kernicterus, nowadays the prevalence of kernicterus in otherwise healthy term neonates in the developed countries is rare. Meanwhile several potential adverse effects of phototherapy have been reported. In the present study we tried to estimate how different the rate of phototherapy for the jaundice of neonates at lower risk of kernicterus would be by different standards. For this purpose, we utilized the records of plasma total bilirubin (TB) values of 1893 healthy neonates of 38 weeks and more which were measured on day 6 for the percentile analysis. However, this database did not include the TB values of the neonates who received phototherapy by day 6. Then the database was corrected with an assumption that TB on day 6 would have been normally distributed if no phototherapy had been performed. The mean and the standard deviation (SD) of corrected database were 11.29 mg/dl (193 μmol/l) and 3.63 mg/dl (62 μmol/l), respectively. Using a standard distribution with these mean and SD, the percents of TB values which exceed 18.0, 19.0, 20.0 and 21.0 mg/dl on day 6 were estimated 3.22%, 1.70%, 0.82% and 0.35%, respectively. Results of the present report would help to estimate the relative rate of phototherapy that is performed for the neonates who are term and otherwise healthy by different standards.

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Section: Discussionmentioning

confidence: 99%

“…But because neonatal jaundice is so common, many neonates at lower risk, most of whom will be unaffected, are treated to prevent kernicterus that would occur rarely [10]. Although reports of clinically significant adverse effects from phototherapy are rare, several possible side effects have been reported [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Percentile analysis of plasma total bilirubin—How different will the rate of phototherapy for jaundice of neonates be by different standards?

Nagao¹,

Watanabe²,

Yokota³

2012

OJPed

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“…In addition, the risk of skin cancer may partly be due to overlap between the spectrum of NNPT and UV radiation. Approximately 0.3% of the blue light comprises UV radiation [30]. NNPT with a total UV irradiance of 10.8 to 32.4 J/cm 2 was reported to cause ultraviolet burns [81].…”

Section: Mechanisms Of Nnpt For Allergic Diseasesmentioning

confidence: 99%

The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

et al. 2011

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Neonatal phototherapy (NNPT), a noninvasive, easily available therapy, has been widely used for the treatment of neonatal jaundice for more than half a century. Its efficiency in decreasing plasma bilirubin concentration is well documented, and NNPT leads to greatly reduced exchange transfusion rates for neonates with hyperbilirubinemia. It is generally accepted that the side effects of NNPT are not serious and seem to be well controlled. This review will focus on these possible side effects as well as the approaches to minimize them.

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“…Pouco se sabe, até hoje, sobre o impacto, em longo prazo, da fototerapia no período neonatal em relação ao risco de surgimento de nevos melanocíticos na infância e na idade adulta 24 .…”

Section: Nevos Melanocíticos Na Infância E Fototerapia No Período Neounclassified

“…Os poucos trabalhos existentes, que procuram correlacionar o uso da fototerapia no período neonatal e o surgimento de maior número de nevos melanocíticos ou displásicos ao longo da vida, apresentam resultados controversos [24][25][26][27][28] .…”

Section: Nevos Melanocíticos Na Infância E Fototerapia No Período Neounclassified

Topical photoprotection in childhood and adolescence

2012

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Objective: Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood through inadequate sun exposure. This review aims to guide pediatricians on appropriate measures of topical photoprotection in children and adolescents, which will positively change the future of these patients. Sources:A review of the literature indexed in MEDLINE/PubMed between the years 1999 and 2012 on photoprotection in childhood was conducted. The most relevant review articles on photoprotection in children and adolescents, photoprotection and vitamin D in neonatal phototherapy and impact on skin cancer, artificial tanning and skin cancer were selected as sources. Summary of the findings:Children and adolescents should adopt appropriate measures of photoprotection in order to decrease the risk of melanoma and non-melanoma skin cancer. Conclusions:There are published data that support the association between sun exposure habits and safe use of topical sunscreens in children and adolescents on the one hand and a reduced occurrence of skin cancer on the other. ResumoObjetivo: A exposição à luz solar na infância ocorre, frequentemente, de forma mais intensa do que em muitos adultos. Dados da literatura comprovam de maneira inequívoca a associação desse comportamento social com o risco de desenvolvimento do melanoma maligno e do câncer cutâneo não melanoma mesmo na vida adulta. Além disso, o fotoenvelhecimento cutâneo é semeado já na infância com a exposição solar inadequada. Esta revisão tem como objetivo orientar os pediatras nas medidas adequadas de fotoproteção tópica nas crianças e adolescentes, o que irá alterar de maneira positiva o futuro desses pacientes. Fontes dos dados:Realizou-se uma revisão da literatura indexada na base de dados MEDLINE/PubMed entre os anos de 1999 e 2012 sobre fotoproteção na infância, selecionando-se como fonte os artigos de revisão mais relevantes, do ponto de vista de abrangência do tema fotoproteção em crianças e adolescentes, fotoproteção e vitamina D, fototerapia na neonatologia e impacto no câncer cutâneo, bronzeamento artificial e câncer cutâneo. Síntese dos dados:Crianças e adolescentes devem adotar medidas adequadas de fotoproteção para diminuir o risco de câncer cutâneo melanoma e não melanoma. Conclusões:Há dados na literatura que suportam a associação de hábitos de exposição solar segura e uso de fotoprotetores tópicos em crianças e adolescentes com a redução da ocorrência do câncer cutâneo.J Pediatr (Rio J). 2012;88(3):203-10: Melanoma maligno, câncer cutâneo, fotoproteção.

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Neonatal Blue-Light Phototherapy Could Increase the Risk of Dysplastic Nevus Development

Cited by 31 publications

References 5 publications

Percentile analysis of plasma total bilirubin—How different will the rate of phototherapy for jaundice of neonates be by different standards?

Percentile analysis of plasma total bilirubin—How different will the rate of phototherapy for jaundice of neonates be by different standards?

The side effects of phototherapy for neonatal jaundice: what do we know? What should we do?

Topical photoprotection in childhood and adolescence

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