Neonatal behavioral toxicity in rats following prenatal exposure to methanol

Infurna, Robert N.; Weiss, Bernard

doi:10.1002/tera.1420330302

Cited by 43 publications

(17 citation statements)

References 16 publications

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“…In a behavioral teratology study, Infurna and Weiss report decrements in suckling and ho ming behaviors of rat pups ( Long-Evans) born to mothers that had received methanol in their drinkin g water for 3 days during the third week of pregnancy. 76 The maternal dose level was 2.5 g/k g/day, a level at least three orders of magnitude higher than the doses that will occur during expected worst-case exposures.…”

Section: H16mentioning

confidence: 90%

The Toxicity of Inhaled Methanol Vapors

Kavet¹,

Nauss²

1990

Critical Reviews in Toxicology

158

102

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Methanol could become a major automotive fuel in the U.S., and its use may result in increased exposure of the public to methanol vapor. Nearly all of the available information on methanol toxicity in humans relates to the consequences of acute, rather than chronic, exposu res. Acute methanol toxicity evolves in a well-understood pattern and consists of an uncompensated metabolic acidosis with superimposed toxicity to the visual system. The toxic properties of methanol are rooted in the factors that govern both the conversion of methanol to formic acid and the subsequent metabolism of formate to carbon dioxide in the folate pathway. In short, the toxic syndrome sets in if formate generation continues at a rate that exceeds its rate of metabolism. Current evidence indicates that formate accumulation will not challenge the metabolic capacity of the folate pathway at the anticipated levels of exposu re to automotive methanol vapor.

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Section: H16mentioning

confidence: 90%

The Toxicity of Inhaled Methanol Vapors

Kavet¹,

Nauss²

1990

Critical Reviews in Toxicology

158

102

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“…Altered auditory responses, which require temporal resolution, have also been reported after methanol exposure of rats at 0.25-3 g/kg (51). Studies of prenatal exposure to methanol in rats have reported effects on fetal development and postnatal behavior (52,53). Rats exposed to methanol via inhalation at 26,000 ppm exhibited an increase in maternal toxicity (unsteady gait) and fetal malformations.…”

Section: Xylenementioning

confidence: 99%

Neurotoxic effects of gasoline and gasoline constituents.

Burbacher

1993

Environ Health Perspect

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This overview was developed as part of a symposium on noncancer end points of gasoline and key gasoline components. The specific components included are methyl tertiary butyl ether, ethyl tertiary butyl ether, tertiary amyl methyl ether, butadiene, benzene, xylene, toluene, methyl alcohol, and ethyl alcohol. The overview focuses on neurotoxic effects related to chronic low-level exposures. A few general conclusions and recommendations can be made based on the results of the studies to date. a) All the compounds reviewed are neuroactive and, as such, should be examined for their neurotoxicity. b) For most of the compounds, there is a substantial margin of safety between the current permissible exposure levels and levels that would be expected to cause overt signs of neurotoxicity in humans. This is not the case for xylene, toluene, and methanol, however, where neurologic effects are observed at or below the current Threshold Limit Value. c) For most of the compounds, the relationship between chronic low-level exposure and subtle neurotoxic effects has not been studied. Studies therefore should focus on examining the dose-response relationship between chronic low-level exposure and subtle changes in central nervous system function.

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“…Infurna and Weiss (1986) exposed pregnant rats to methanol in drinking water (2%, v/v) during GD 15-17 or 17-19. Both groups of exposed offspring showed disrupted suckling behavior on Postnatal Day (PND) 1 and difficulties in locating nesting material from the home cage on PND 10.…”

mentioning

confidence: 99%

“…It was used by Infurna and Weiss (1986) for a prenatal methanol study in which methanol was administered via the dam's drinking water and by Chen et al (1982) for studies of prenatal ethanol effects.…”

mentioning

confidence: 99%

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Perinatal Methanol Exposure in the Rat II Behavioral Effects in Neonates and Adults

Stern¹,

Cox

Preston³

et al. 1997

Toxicol Sci

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The use of methanol as a component of automobile fuel will increase perinatal exposures in the general population. Few studies have addressed questions concerning neurotoxicity stemming from such exposures. In the current study, four cohorts of pregnant Long-Evans rats, each cohort consisting of an exposure and a control group, were exposed to 4500 ppm methanol vapor in Rochester-type inhalation chambers for 6 hr daily beginning on Gestation Day 6. Exposure continued for both dams and pups through Postnatal Day 21 (PND 21) to model gestational and neonatal toxicity in humans. Several behavioral procedures were used to assess exposure effects in the offspring. Male-female littermates were studied whenever possible to examine sex differences, with one pair from a litter for each procedure. Exposure to methanol did not affect suckling latency and nipple attachment on PND 5 or performance on an aversive olfactory conditioning procedure on PND 10. Exposure to methanol did alter performances in a motor activity procedure. Methanol-exposed neonates were less active on PND 18, but more active on PND 25 than the equivalent control group pups. Two operant conditioning procedures, not used previously in this context, assayed other littermates as adults. A fixed ratio schedule required the rat to rotate a running wheel a specified number of revolutions to obtain food-pellet reinforcers. When the fixed ratio requirement changed, number of responses (revolutions) per 1-hr session displayed a complex interaction with treatment Changes in performance over the course of training differed between males and females depending on exposure to methanol. Compared to initial baseline performances, methanolexposed males showed decreases, and methanol-exposed females increases, in the rate of running. A stochastic spatial discrimination procedure permitted subjects to respond on any three levers, with the probabilities of food-pellet delivery determined by the location of the preceding response. A reinforcement matrix defined

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Neonatal behavioral toxicity in rats following prenatal exposure to methanol

Cited by 43 publications

References 16 publications

The Toxicity of Inhaled Methanol Vapors

The Toxicity of Inhaled Methanol Vapors

Neurotoxic effects of gasoline and gasoline constituents.

Perinatal Methanol Exposure in the Rat II Behavioral Effects in Neonates and Adults

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