Neonatal bacteremia in a neonatal intensive care unit: analysis of causative organisms and antimicrobial susceptibility

Abstract

Background: Bangladesh has a neonatal death rate that is substantially high and demands urgent attention. Objective: This retrospective study was performed to determine the incidence of bacterial neonatal sepsis condition in the Chittagong area of Bangladesh with focus on various demographic characteristics of neonates, causative organisms and their antibiotic susceptibility. Methodology: Blood culture was performed on all neonates with risk factors or signs of suggestive sepsis. Blood samples were cultured using tryptone soya broth (TSB-blood broth) according to standard method. Results: From the 1400 neonates 104 had positive blood culture for neonatal sepsis infection. Among the infected children 40 (38.46%) were born in the hospital and 64 (61.54%) were born at home. The EONS (Early Onset Neonatal Sepsis) accounted for 68 (65.38%) and LONS (Late Onset Neonatal Sepsis) accounted for 36 (34.62%). Among the isolated organism Klebsiella pneumoniae accounted for 79 (75.96%), Serratia marcescens 19 (18.27%), Pseudomonas aeruginosa 04 (3.85%) and Staphylococcus aureus accounted for 02 (1.92%). Among the isolated species 102 were attributed to G (-ve) bacteria and 02 were attributed to G (+ve) bacteria. Most of the G (-ve) bacteria showed resistance to commonly used antibiotics such as ampicillin, ceftriaxon and gentamicin. In this study all isolates showed sensitivity to the imipenem. Conclusion: Collection of up-to-date data is mandatory for appropriate use of antibiotics.

Neonatal Septicemia: Isolation, Identification and Antibiotic Sensitivity Pattern of Bacteria in a Tertiary Hospital in Bangladesh

“…Isolation rate of Klebsiella pneumoniae in the present study was 6.06%, which was comparable to some other studies 7,17,19,24 . A higher isolation rates was also observed in other studies 6,19,25 . Pseudomonas aeruginosa was isolated at the rate of 3.03% which was comparable to other studies 6,[24][25][26] .…”

“…A higher isolation rates was also observed in other studies 6,19,25 . Pseudomonas aeruginosa was isolated at the rate of 3.03% which was comparable to other studies 6,[24][25][26] . A higher isolation rates was also observed by others 7,22 .…”

“…In Bangladesh, a few studies have reported on causative agents of neonatal septicaemia and their antibiotic sensitivity pattern [6][7][8] . The spectrum of organisms that causes neonatal sepsis changes over times and varies from region to region.…”

Prevalence and Associated Risk Factors of Sepsis among Neonates Admitted into Neonatal Intensive Care Units of Public Hospitals in Dhaka

“…Our study found a high prevalence of neonatal sepsis (69.36%) in NICU admitted patients. Another study at Chittagong Medical College Hospital, Bangladesh had almost the same findings of early-onset neonatal sepsis (65.38%) and late-onset neonatal sepsis (34.62%) [18]. Although the findings appeared similar, the study from Motara et al showed about 5% earlyonset and 91% late-onset neonatal sepsis [25].…”

“…Some studies conducted in Bangladesh focused only on the bacteriological profile and antimicrobial susceptibility regarding neonatal sepsis [18][19][20]. As neonatal sepsis encompasses a number of diseases that are preventable, along with lab-based study for causative organisms, it is crucial to identify the risk factors related to it [21].…”