Neonatal bacillus Calmette–Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells

Li, Qian; Shen, Huahao

doi:10.1038/aps.2008.3

Cited by 30 publications

(19 citation statements)

References 52 publications

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“…These results demonstrated that C-K regulated the T cell response by inhibiting the differentiation and activation of CD4 + T cells instead of reducing the number of CD4 + T cells. Tregs control the responses of APCs and effector T cells in the periphery through direct interaction with these cells or through anti-inflammatory cytokine production, and they play an important role in limiting inflammation and regulating adaptive immunity [43,44] . C-K restored the percentage of Tregs, which may be one of the mechanisms underlying the anti-CIA effects of C-K as well as its anti-inflammatory and immunosuppressive effects.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

et al. 2014

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“…47 BCG vaccination has long been known to be a potent inducer of IFN-g-secreting Th1 responses and Tregs. 15,48,49 The increase in the levels of circulating immune factors (e.g., cytokines, chemokines or other factors), many of which can enter the CNS. These immune factors may promote microglia activation and proliferation and thus increasing the expression of neurotrophins.…”

Section: Discussionmentioning

confidence: 99%

Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons

Zhang

Zou

et al. 2015

Human Vaccines & Immunotherapeutics

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y These authors equally contributed to this work.Keywords: dendritic complexity, fractal dimension, neurotrophin, spine, sholl analysis Abbreviations: BCG, Bacillus Calmette-Gu erin; CNS, central nevers system; BDNF, brain derived neurotrophic factor; IGF-1, insulin-like growth factor 1; AMPA, a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptorDendritic structure is sensitive to changes in the environment during brain development. Accumulating evidence has demonstrated that early immune activation can significantly affect neuronal development. Our study concentrated on the morphological study of neural dendrites and spines in the hippocampal CA1 area using Diolistic labeling with Sholl analysis and fractal analysis. The results revealed that Bacille Calmette-Gu erin (BCG) vaccination enhanced dendritic complexity, as reflected by the increased number of intersections, number of branch points and fractal dimension, and promoted neurite outgrowth. In addition, BCG increased the density and promoted the maturation of dendritic spines. The alterations in dendritic structure and spine morphology were observed at 2 and 4 w, but the differences were more apparent at 4 w than at 2 w. However, no significant difference was observed at 8 w. Furthermore, we observed that BCG increased the expression of hippocampal brain derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). Hippocampal BDNF/IGF-1 was positively correlated with apical dendritic length, fractal dimension, and spine density. Taken together, we show in this study that neonatal BCG vaccination promotes dendritic development in developing hippocampal CA1 neurons, most likely by increasing the expression of BDNF and IGF-1 in the hippocampus.

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“…For instance, vaccination of mice with bovis Bacille Calmette–Guérin (BCG) or recombinant BCG expressing house dust mite protein Derp, reduced subsequent allergic airway inflammation after OVA or Derp sensitization and challenge, respectively. In addition, increased numbers of Foxp3+ cells in the lung and enhanced expression of CTLA-4 and elevated levels of IL-10 and TGF-b were observed (95, 96). Instead, infection early in life with respiratory syncytial virus (RSV) impaired Treg function and exacerbated allergic airway inflammation in mice (97).…”

Section: Treg Cells In the Lungmentioning

confidence: 99%

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

Lehtimäki

Lahesmaa

2013

Front. Immunol.

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Regulatory T cells (Treg) are needed in the control of immune responses and to maintain immune homeostasis. Of this subtype of regulatory lymphocytes, the most potent are Foxp3 expressing CD4+ T cells, which can be roughly divided into two main groups; natural Treg cells (nTreg), developing in the thymus, and induced or adaptive Treg cells (iTreg), developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, non-redundant roles in the immune system, with nTreg cells mainly maintaining tolerance toward self-structures, and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body.

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Neonatal bacillus Calmette–Guérin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4+CD25+ T-regulatory cells

Abstract: Neonatal BCG vaccinations ameliorate de novo local eosinophilic inflammation induced by allergen and increase the numbers of CD4+CD25+ Treg cells and Foxp3 expression. The cell-cell contact inhibition and regulatory cytokine production may be involved in the regulatory mechanism.

Cited by 30 publications

References 52 publications

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

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