Neonatal Asphyxia in the Rat: Greater Vulnerability of Males and Persistent Effects on Brain Monoamine Synthesis

Simon, Nicole; Volicer, Ladislav

doi:10.1111/j.1471-4159.1976.tb06470.x

Cited by 33 publications

(8 citation statements)

References 41 publications

(10 reference statements)

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“…The rate of 5-HT synthesis in the forebrain was also considerably (48%) higher in the females. Comparable sex-differences in turnover were reported by Simon and Volicer (1976) and Carlsson et al (1985) in the brains ~of 40 and 60-75 day old rats respectively. Other work on 5-HT and 5-HIAA 94 D.J.…”

Section: Introductionsupporting

confidence: 64%

Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT

Haleem¹,

Kennett²,

Curzon³

1990

J. Neural Transmission

109

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Brain regional 5-hydroxytryptamine (5-HT) and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations tended to be slightly higher in female rats than in males but differences were substantial only in the hippocampus where female values were 34% and 36% higher respectively. These findings were consistent with the synthesis rates of 5-HT as this was 53% greater in the female than in the male hippocampi. Other regions did not show significant sex differences. The 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 1 mg/kg sc) caused comparable decreases of 5-HT synthesis rate in both sexes and in all regions studied except the hippocampus where the percentage decrease was twice as large in the females (-64%) as in the males (-32%) so that the sex difference in 5-HT synthesis in this region largely disappeared. The results are discussed in relation to sex differences in behaviour and hippocampal function.

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Section: Introductionsupporting

confidence: 64%

Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT

Haleem¹,

Kennett²,

Curzon³

1990

J. Neural Transmission

109

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show abstract

“…Rosecrans andSchechter (1972) and Rosecrans (1970) observed a higher 5-HT turnover in the telencephalon and diencephaton of females. Simon and Volicer (1976) found no sex differences in 5-HT steadystate concentrations in whole brains of 40-day-old rats but reported a higher serotonin synthesis rate in females. Skillen et al (1961) found no differences in whole brain 5-HT levels between the sexes.…”

Section: Introductionmentioning

confidence: 81%

Rat brain serotonin: Biochemical and functional evidence for a sex difference

Carlsson

Svensson

Eriksson

et al. 1985

J. Neural Transmission

110

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Male and female rats were compared with respect to brain serotonin (5-HT) levels, synthetic capacity, receptor sensitivity, and CNS functions. Levels of whole brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) were higher in females. The accumulation of 5-HT after treatment with the monoamine oxidase inhibitor pargyline alone and in combination with the 5-HT precursor L-tryptophan was greater in females than in males. 5-HT increased and 5-HIAA decreased to the same extent in both sexes after administration of the 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). The temperature fall after all drug treatments was greater in females, but the "5-HT behavioural syndrome" was more pronounced in females merely after pargyline plus tryptophan; the behavioural response after 8-OH-DPAT did not differ between the sexes. These results are indicative of sex differences in the brain 5-HT neuronal systems. They are discussed in relation to differences between males and females in sexual behaviour, aggression and affective disorders.

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“…For instance, within 7 days after birth, female rats appear to have higher catecholaminergic and serotonergic neurotransmitter activity compared to male rats [25,26]. Additionally, it was shown that neonatal asphyxia could induce long-lasting alterations in the serotonin metabolism of male but not in female rats [27]. Furthermore, several studies have reported sex differences in the resistance to an acute hypoxic challenge in the neonatal animals [14,15].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Influence of Ischemia-Hypoxia-Induced Intrauterine Growth Retardation on Brain Development and Behavioral Activity in Rats

et al. 2001

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The effects of intrauterine growth retardation (IUGR) on brain histological or functional development were examined in rats. IUGR was induced by ligating the bilateral uterine arteries at day 17 of pregnancy. On day 22 of pregnancy, cesarean section was performed, and pups with a birth weight of <2 SD of the mean birth weight of control pups were regarded as IUGR rats. Morphological changes of the brain were studied by Nissl’s staining at different timepoints during prenatal and postnatal periods. For behavioral study, an open-field test was performed at 5, 7 and 10 weeks after birth. Histological studies showed the migration disorder of the neurons in the cerebral cortex from embryonic day 17 to postnatal day (PD) 49. The open-field test revealed locomotor disturbance at PD49 in male IUGR rats, but not in female IUGR rats or control rats. It is concluded that IUGR due to antenatal ischemia-hypoxia causes morphological changes in the central nervous system, and induces behavioral impairment, particularly in male rats.

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Neonatal Asphyxia in the Rat: Greater Vulnerability of Males and Persistent Effects on Brain Monoamine Synthesis

Cited by 33 publications

References 41 publications

Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT

Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT

Rat brain serotonin: Biochemical and functional evidence for a sex difference

Prenatal Influence of Ischemia-Hypoxia-Induced Intrauterine Growth Retardation on Brain Development and Behavioral Activity in Rats

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