Neonatal Asphyxia, Definitive Markers and Hearing Loss

Mencher, Lenore S.; Mencher, George T.

doi:10.3109/00206099909073038

Cited by 28 publications

(19 citation statements)

References 12 publications

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“…The presence of stage III encephalopathy has previously been identified as a definitive marker of hearing loss in asphyxiated infants and its tendency for persistent abnormal AABR in the newborn (30, 31). This was also corroborated in this study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hearing Impairment Among High-Risk Newborns in Ibadan, Nigeria

et al. 2018

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The burden of severe hearing impairment is increasing with two-thirds of these hearing impaired people residing in developing countries. Newborn hearing screening helps to identify early, babies who need intervention in order to prevent future disability. Neither universal nor targeted hearing screening programme is available in Nigeria.Objectives: This study was carried out to assess the prevalence of hearing impairment among high-risk newborns in UCH and the associated risk factors.Materials and Methods: Two hundred one newborns in the neonatal unit of UCH with risk factors for hearing impairment had hearing screening done using automated auditory brainstem response (AABR) at 30, 45, and 70 dB at admission and discharge, and those that failed screening at discharge were rescreened at 6 weeks post-discharge.Results: Eighty-three (41.3%) and 32 (15.9%) high-risk newborns failed at admission and discharge screening respectively, and 19 (9.5%) still failed at follow up screening. The majority of hearing loss at follow up was bilateral (94.7%) and severe (52.6%). The risk factors associated with persistent hearing loss at follow up were acute bilirubin encephalopathy (RR = 11.2, CI: 1.4–90.6), IVH (RR = 8.8, CI: 1.1–71.8), meningitis (RR = 4.8, CI: 1.01–29), recurrent apnoea (RR = 2.7, CI: 1.01–7.3), severe perinatal asphyxia NNE III (RR = 7, CI: 2.4–20.2).Conclusion: Severe and bilateral hearing impairment is a common complication among high risk newborns in UCH persisting till 6 weeks post-neonatal care. Severe perinatal asphyxia with NNE III, ABE, IVH, meningitis and administration of amikacin for more than 5 days were significant risk factors. We recommend that SCBU graduates with these risk factors should have mandatory audiologic evaluation at discharge.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Hearing Impairment Among High-Risk Newborns in Ibadan, Nigeria

et al. 2018

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“…Those infants who have both a low Apgar score and clinical signs of hypoxic-ischaemic encephalopathy (HIE), i.e. perinatal hypoxia-ischaemia (HI), are more likely to have hearing impairment [2,[5][6][7]. Otoacoustic emissions (OAEs), particularly distortion product otoacoustic emissions (DPOAEs), have been widely used to examine cochlear function [1,8,11,12].…”

Section: Introductionmentioning

confidence: 99%

Distortion product otoacoustic emissions at 6 months in term infants after perinatal hypoxia-ischaemia or with a low Apgar score

2007

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Distortion product otoacoustic emissions (DPOAEs) were analyzed at 6 months of age in term infants who had perinatal hypoxia-ischaemia (HI) and those who had a low Agar score alone to detect any abnormalities in cochlear function and any difference between the two groups of infants. The f2 primary tone was presented at ten frequencies (0.5-10 kHz). Both the left and right ears were tested. Compared to normal term controls, both the infants after perinatal HI and those with a low Apgar score alone showed lower DPOAE pass rates, mainly at 1-4 kHz at which the pass rates were decreased significantly (P < 0.05-0.01). The general pattern of DPOAE pass rates at different frequencies was similar in the two groups of infants. The pass rates at 1, 5 and 6 kHz tended to be lower in the infants after perinatal HI than those with a low Apgar score alone, although not statistically significant. Conclusions At 6 months of age, infants after perinatal HI or with a low Apgar score alone had a relatively poor cochlear function, mainly at 1-4 kHz. There are no major differences between the two groups of infants.

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“…Hypoxia-ischaemia, occurring particularly in the perinatal period, is one of the high risk factors for sensory or sensorineural hearing impairment [1,6,7,10,13,14]. However, little is known about which frequencies in the audiogram of the neonatal cochlea are affected by hypoxia-ischaemia.…”

Section: Introductionmentioning

confidence: 99%