Neonatal apnea and gastroesophageal reflux (GER): is there a problem?

Jawdeh, Elie G. Abu; Martin, Richard J.

doi:10.1016/s0378-3782(13)70005-7

Cited by 33 publications

(20 citation statements)

References 18 publications

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“…[20][21][22][23] Third, infants in the home monitor group had a significantly longer length of stay compared to infants discharged home without a monitor. First, infants in the home monitor group were of greater GA at birth and at the time of discharge.…”

Section: Discussionmentioning

confidence: 93%

Diagnostic Evaluation and Home Monitor Use in Late Preterm to Term Infants With Apnea, Bradycardia, and Desaturations

Veit

Amberson

Freiberger

et al. 2016

Clin Pediatr (Phila)

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Apnea, bradycardia, and oxygen desaturation events are a common in neonatal intensive care units, with relevant literature to date largely focusing on very low birth weight and extremely low birth weight infants. We conducted a retrospective review of infants born at ≥34 weeks gestational age at 2 tertiary neonatal intensive care units in Boston, MA, between January 2009 and December 2013. Our objectives included (1) describing the diagnostic evaluations performed in late preterm to term infants with discharge-delaying apnea, bradycardia, or oxygen desaturation events and (2) identifying variables associated with home monitor use. Of the 741 eligible infants identified, diagnostic evaluations were variable and infrequent with blood culture, blood glucose, and head ultrasound performed most commonly. The likelihood of home monitor use was greater in infants with either a prolonged inpatient stay or greater gestational age at birth.

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Section: Discussionmentioning

confidence: 93%

Diagnostic Evaluation and Home Monitor Use in Late Preterm to Term Infants With Apnea, Bradycardia, and Desaturations

Veit

Amberson

Freiberger

et al. 2016

Clin Pediatr (Phila)

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“…Further, reduction in stomach pH would not lessen the refluxate volume that stimulates laryngeal mechanoreceptors, causing apnoea. There have been no randomised trials that have demonstrated acid suppression leading to improvements in AOP, while increased risks of sepsis and necrotising enterocolitis have been documented 31. Therefore, a role for gastric acid suppression is not currently supported in the treatment of AOP, and elimination of this practice was targeted in the Choosing Wisely campaign 32…”

Section: Treatmentmentioning

confidence: 99%

Treatment options for apnoea of prematurity

Morton

Smith

2016

Arch Dis Child Fetal Neonatal Ed

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Apnoea of prematurity (AOP) affects almost all infants born at <28 weeks gestation or with birth weight <1000 g. When untreated, AOP may be associated with negative outcomes. Because of these negative outcomes, effective treatment for AOP is an important part of optimising care of preterm infants. Standard treatment usually involves xanthine therapy and respiratory support. Cutting-edge work with stochastic vibrotactile stimulation and new pharmaceutical agents continues to expand therapeutic options. In this article, we review the pathophysiology of AOP, associated conditions and treatment options.

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“…The frequent coexistence of CR events and GER symptoms in infants gives caregivers and neonatologists the perception that there is a causal association between these two events and has become the basis for an over‐prescription of antacid drugs that may increase the risk of sepsis and necrotizing enterocolitis . The perception of a causal relationship between CR events and GER symptoms is strengthened by the fact that both types of symptoms often coexist in premature infants . Regardless, the nature of the relationship between these events has not yet been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] The perception of a causal relationship between CR events and GER symptoms is strengthened by the fact that both types of symptoms often coexist in premature infants. 11 Regardless, the nature of the relationship between these events has not yet been fully clarified. Although some authors demonstrated the existence of a causal correlation between GER and CR events, 6,12,13 the results of several recent studies rejected that hypothesis.…”

mentioning

confidence: 99%