Neonatal Anthropometric Charts: The Italian Neonatal Study Compared With Other European Studies

Bertino, Enrico; Spada, Elena; Occhi, L; Coscia, Alessandra; Giuliani, Francesca; Gagliardi, Luigi; Gilli, G; Bona, Gianni; Fabris, C; Curtis, Mario De; Milani, Silvano

doi:10.1097/mpg.0b013e3181da213e

Cited by 375 publications

(292 citation statements)

References 29 publications

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“…It is important to underline that the prevalence of macrosomia in BWS cohorts depends on its definition; we opted for the permissive definition of neonatal weight 490th percentile as of more diffuse usage, already employed in the definition of BWS diagnostic criteria, 4 and used to define the large-forgestational-age newborn in our setting. 14 We confirm the increased prevalence of omphalocele in IC2-LoM further show that they have lower incidence of organ enlargement, suggesting that wall defects are primarily caused by developmental anomalies of the abdominal wall rather than consequent to increased abdominal pressure; nevus flammeus and ear signs are also particularly frequent in IC2-LoM patients (about half of the cases).…”

Section: Phenotypes In Beckwith-wiedemann Syndromesupporting

confidence: 77%

(Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome

et al. 2015

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Beckwith-Wiedemann syndrome (BWS) is characterized by cancer predisposition, overgrowth and highly variable association of macroglossia, abdominal wall defects, nephrourological anomalies, nevus flammeus, ear malformations, hypoglycemia, hemihyperplasia, and organomegaly. BWS molecular defects, causing alteration of expression or activity of the genes regulated by two imprinting centres (IC) in the 11p15 chromosomal region, are also heterogeneous. In this paper we define (epi)genotype-phenotype correlations in molecularly confirmed BWS patients. The characteristics of 318 BWS patients with proven molecular defect were compared among the main four molecular subclasses: IC2 loss of methylation (IC2-LoM, n = 190), IC1 gain of methylation (IC1-GoM, n = 31), chromosome 11p15 paternal uniparental disomy (UPD, n = 87), and cyclin-dependent kinase inhibitor 1C gene (CDKN1C) variants (n = 10). A characteristic growth pattern was found in each group; neonatal macrosomia was almost constant in IC1-GoM, postnatal overgrowth in IC2-LoM, and hemihyperplasia more common in UPD (Po0.001). Exomphalos was more common in IC2/CDKN1C patients (Po0.001). Renal defects were typical of UPD/IC1 patients, uretheral malformations of IC1-GoM cases (Po0.001). Ear anomalies and nevus flammeus were associated with IC2/CDKN1C genotype (Po0.001). Macroglossia was less common among UPD patients (Po0.001). Wilms' tumor was associated with IC1-GoM or UPD and never observed in IC2-LoM patients (Po0.001). Hepatoblastoma occurred only in UPD cases. Cancer risk was lower in IC2/CDKN1C, intermediate in UPD, and very high in IC1 cases (P = 0.009).In conclusion, (epi)genotype-phenotype correlations define four different phenotypic BWS profiles with some degree of clinical overlap. These observations impact clinical care allowing to move toward (epi) genotype-based follow-up and cancer screening.

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Section: Phenotypes In Beckwith-wiedemann Syndromesupporting

confidence: 77%

(Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome

et al. 2015

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“…BW was measured within 1 hour from delivery with an electronic weighing scale and recorded to the nearest 5 g. BL and HC were measured within 1 day from delivery with a Harpenden neonatometer and an inelastic tape, respectively, and recorded to the nearest millimetre [16]. Information on parents' age, body weight, height, level of education (secondary school or lower, high school, university), profession (employed or unemployed), smoking and parity was recorded.…”

Section: Enrolment Visitmentioning

confidence: 99%

Infant Feeding Practices in the First Year of Life in a Metropolitan Italian Cohort

Cinelli¹,

Fabrizi²,

Shashaj³

et al. 2018

JFNR

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Infant feeding choices are pivotal for growth and may affect the risk of overweight later in life. The objective of the study was to explore: (i) adherence to World Health Organization (WHO, exclusive breast feeding, BF, in the first 6 months) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPHGAN, complementary feeding, CF, between 17 and 26 weeks of age and cow's milk introduction at 1 year of age) recommendations; (ii) and the effect of these practice on infants' anthropometrics and adiposity at 1 year of age. The study was based on the sample of infants (n = 462) from the -Feeding‖ cohort whose feeding behaviours were monthly investigated from birth to 1 year of age and anthropometrics, thickness of epicardial adipose (EAT), abdominal subcutaneous, and visceral adipose tissues, measured at 1 year of age. Exclusively breast-fed infants were 69.5% (n=321) at birth but 19.9% (n=92) at 6 months of age. CF was introduced at the median age of 5 (4-6), with 64.5% (n=298) of infants complying the ESPHGAN guidelines, while cow's milk was introduced at the age of 11 (10-12) months. Age of CF was associated with weight-to-length ratio (coeff.= -0.002, 95% CI -0.003 to -0.000, p = 0.018, r). Age of cow's milk introduction with weight-to-length ratio as well (coeff.= 0.001, 95% CI 0.000, 0.002, p=0.025; and EAT (coeff.=0.038, 95% CI 0.012 to 0.063, p = 0.004) at 1-y. Feeding practices complied with WHO recommendations in one infant out of five, and ESPHGAN recommendations in about seven out of ten. Early CF and cow's milk were both associated with anthropometrics at 1-y, while exclusively BF was not.

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“…gestational age and gestational weight gain at delivery, blood pressure measurements, urinary protein levels, any complications during pregnancy, mode of delivery, neonatal sex and birth weight (neonatal weight was also expressed as centiles, according to birth-weight references for the Italian population) (Bertino et al, 2010).…”

Section: Subjects and Data Collectionmentioning

confidence: 99%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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Neonatal Anthropometric Charts: The Italian Neonatal Study Compared With Other European Studies

Abstract: The existing European neonatal charts, based on more or less recent data, were found to be inappropriate for Italy. Until an international standard is developed, the use of national updated reference charts is recommended.

Cited by 375 publications

References 29 publications

(Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome

(Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome

Infant Feeding Practices in the First Year of Life in a Metropolitan Italian Cohort

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

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