Neonatal and postneonatal mortality in very low birthweight infants.

Yu, V. Y. H.; Watkins, Alan; Bajuk, Barbara

doi:10.1136/adc.59.10.987

Cited by 29 publications

(7 citation statements)

References 10 publications

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“…The disproportionately higher neonatal, post neonatal and infant mortality seen here is consistent with previous reports from more advanced countries (4,(7)(8)(9). The advanced countries, however, not only have considerably lower infant mortalities (10) they also enjoy smaller proportionate representation of VLBW infants in their birth cohorts (11).…”

Section: Discussionsupporting

confidence: 81%

The contribution of very low birth weight death to infant mortality

Were

Bwibo²

2010

E Af Med Jrnl

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Background: Infant mortality remains high in many developing countries in which the contribution of deaths among infants born very low birth weight (VLBW) may be considerable. This contribution has however not been quantified in most such countries. This paper explores a model that can be used in this respect. Objective: To determine the contribution of very low birth weight infants towards the overall infants deaths in Kenya. Design: Prospective cohort study. Setting: Kenyatta National Hospital, Pumwani Maternity Hospital and Kilifi District Hospital. Subjects: Very low birth weight infants followed up for a period of one year. Results: The neonatal, post-neonatal and infant mortalities for the cohort were 442, 139 and 581/1000 respectively. These were thirteen, three and seven times higher than the national averages respectively. Of the national birth cohort of 1,300,000 during that year, it was estimated that between 15,600 (1.2%) and 24,700 (1.9%) were born VLBW. Given this VLBW infant burden and extrapolating the infant mortality observed in this study to the general population, between 9,064 (8.9%) and 14,351(14.2%) of the 101,400 (78/1000) infants who die during infancy in the country are born VLBW. Conclusion: The cohort reports very high infant mortality for VLBW infants when compared to the general population. Despite constituting less than 2% of the birth cohort, these infants contribute between 8.9% and 14.2% of all infant deaths.

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Section: Discussionsupporting

confidence: 81%

The contribution of very low birth weight death to infant mortality

Were

Bwibo²

2010

E Af Med Jrnl

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“…Our study is 1 of a few population-based studies to investigate postdischarge mortality in VLBW infants. [13][14][15] Population-base studies in contrast to single institutions' experience [15][16][17][18] are larger and more representative, and their findings may be generalized. Two previous studies from the 1980s focused on center-specific mortality rates after NICU discharge, reporting a ninefold and sevenfold excess in postneonatal mortality among NICU graduates compared with non-NICU graduates.…”

Section: Discussionmentioning

confidence: 99%

Postdischarge Infant Mortality Among Very Low Birth Weight Infants: A Population-Based Study

et al. 2007

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“…7,8 Six percent of ELBW deaths in the first year occurred in the postneonatal period. 9 Small-for-gestational-age (SGA) infants are more mature than their appropriately grown-for-gestation (AGA) counterparts in a weightselected cohort. Reporting outcome separately for these subgroups is therefore necessary, as SGA infants have a better survival rate but often worse developmental outcome.…”

Section: Institution-based Studiesmentioning

confidence: 99%

Developmental Outcome of Extremely Preterm Infants

Yu¹

2000

Am J Perinatol

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Institution-based studies from perinatal centers are reporting encouraging survival and developmental outcome in extremely preterm infants, but population-based studies of all such births within a geographical-defined region are necessary to examine the impact of perinatal-neonatal care on the entire community. We have reported that their perinatal mortality and severe disability rate were significantly lower in those born within perinatal centers compared with those born elsewhere. Promotion of "in utero transfer" is associated with a significant improvement in their survival and developmental outcome. Postnatal surfactant therapy, which began a decade ago, saw a doubling of the survival rate for infants born as early as 24-26 weeks, while their severe disability rate remains below 10%. Although surfactant and mechanical ventilation are expensive therapies, the resulting improvement in outcome was responsible for a reduction in the cost per additional quality-adjusted life-year gained.

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Neonatal and postneonatal mortality in very low birthweight infants.

Cited by 29 publications

References 10 publications

The contribution of very low birth weight death to infant mortality

The contribution of very low birth weight death to infant mortality

Postdischarge Infant Mortality Among Very Low Birth Weight Infants: A Population-Based Study

Developmental Outcome of Extremely Preterm Infants

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