Neonatal and Long-Term Neuroendocrine Effects of Fetal Alcohol Exposure1

Taylor, Anna N.; Branch, Berrilyn J.; Kokka, Norio; Poland, Russell E.

doi:10.1159/000406886

Cited by 26 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, these findings indicate that a number of physiological measures normally associated with stress are enhanced in pups exposed to alcohol prenatally. The fact that alcohol-treated animals, when adult, were no more sensitive than controls to the cold stressor indicates that alcohol-treated animals do acquire normal thermoregulatory abilities, even though they may be delayed in such development (Taylor, Branch, Kokka, & Poland, 1983). This is in accord with a hypothesis linking the hyperactivity seen in juvenile alcohol-treated offspring with an initial absence of thermoregulatory ability.…”

Section: Discussionsupporting

confidence: 59%

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Bond

1985

Psychobiology

View full text Add to dashboard Cite

Rats were fed a liquid diet containing alcohol from Days 6-19 of gestation. Controls were pairfed the same diet with sucrose substituted for ethanol, or were allowed ad-lib chow and water. The activity of the offspring was observed in isolation at 10, 16,22, or 28 days of age. Offspring exposed to alcohol prenatally were hyperactive relative to controls at 16 and 22 days, but not at 10 or 28 days. The presence of home-cage shavings in the test chamber affected the activity of the three groups similarly. In a second study, isolation-induced activity was observed at a test room temperature of 23 0 or 33 0 C. Offspring exposed to alcohol were hyperactive in comparison with pair-fed controls, at both 16 and 22 days, when tested at 23 0 C. However, the difference in activity was attenuated at 16 days and abolished at 22 days if pups were tested at 33 0 C. These findings indicate that the hyperactivity displayed by alcohol-treated offspring may be due in part to their experiencing greater thermal stress when removed from their dam and littermates.

show abstract

Section: Discussionsupporting

confidence: 59%

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Bond

1985

Psychobiology

View full text Add to dashboard Cite

show abstract

“…Furthermore, reductions in hippocampal cell loss in H animals may influence their performance on tasks associated with spatial learning and memory because performance on such spatial tasks as the Morris water maze has been shown to be disrupted by bilateral lesions to the hippocampus (Morris, Garrud, Rawlings, & O'Keefe, 1982). In contrast to the effects of handling, prenatal ethanol exposure results in prolonged and/or enhanced adrenocort cotropin hormone (ACTH) and CORT responses to a variety of stressors (Taylor, Branch, Kokka, & Poland, 1983;Weinberg, 1992;1993;Angelogianni & Gianoulakis, 1989;Taylor, Branch, Liu, & Kokka, 1982). Therefore, not only may impaired performance on spatial learning and memory tasks in E animals be related to stress-induced performance deficits associated with increased HPA activity but aging E animals also may experience an accelerated rate of impairment in hippocampal-mediated functions.…”

Section: Introductionmentioning

confidence: 99%

Prenatal ethanol exposure and spatial navigation: Effects of postnatal handling and aging

Gabriel

Johnston

Weinberg

2002

Developmental Psychobiology

View full text Add to dashboard Cite

Prenatal ethanol exposure results in spatial navigation deficits in young and mid-aged animals. In contrast, postnatal handling attenuates spatial deficits that emerge with age in animals that are not handled. Therefore, we investigated the ability of handling to attenuate spatial deficits in animals prenatally exposed to ethanol (E). Sprague-Dawley male offspring from E, pair-fed (PF), and control (C) groups were handled (H) or nonhandled (NH) from 1 to 15 days of age and tested on the Morris water maze at 2 or 13 to 14 months of age. In young animals, H-E males had longer latencies to locate the submerged platform, and E animals, across handling conditions, showed altered search patterns compared to their PF and C counterparts. Mid-aged animals had longer latencies than young animals, with no differences among E, PF, and C animals. However, corticosterone levels were higher in mid-aged E than in C males. Handling did not attenuate impairments associated with either prenatal ethanol exposure or aging.

show abstract

“…Of particular relevance to the present study, prenatal ethanol exposure is known to alter the responsivity and regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Under nonstressed conditions, rats prenatally exposed to ethanol (E) typically exhibit normal levels of the stress hormones adrenocorticotropin (ACTH) and corticosterone (CORT) (Kim et al, 1999b;Osborn et al, 1996;Taylor et al, 1983;Weinberg, 1992;Weinberg and Gallo, 1982), released from the anterior pituitary and adrenal glands, respectively. However, in response to stressors including intermittent foot shock (Nelson et al, 1986), novel environment (Weinberg, 1988), restraint (Gabriel et al, 2001;Weinberg, 1988Weinberg, , 1992, ether (Angelogianni and Gianoulakis, 1989;Weinberg and Gallo, 1982), and cold (Angelogianni and Gianoulakis, 1989;Kim et al, 1999a), as well as to drugs such as ethanol and morphine (Nelson et al, 1986;Taylor et al, 1981) and to immune challenges (Lee and Rivier, 1996;Lee et al, 2000), E animals show increased and/or prolonged ACTH and/or CORT elevations compared with controls (C).…”

mentioning

confidence: 99%

Effects of Mineralocorticoid and Glucocorticoid Receptor Blockade on Hypothalamic–Pituitary–Adrenal Function in Female Rats Prenatally Exposed to Ethanol

Glavas¹,

Yu²,

Weinberg³

2006

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

E females showed enhanced HPA responses to both MR and GR blockade compared with PF and C before restraint as well as a different pattern of responsivity during and following restraint. While receptor blockade had some effect on CORT responses in PF females, changes in ACTH appear specific to ethanol. These findings suggest that the balance between HPA drive and feedback may be altered in E compared with C females.

show abstract

Neonatal and Long-Term Neuroendocrine Effects of Fetal Alcohol Exposure1

Cited by 26 publications

References 0 publications

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Prenatal alcohol exposure and offspring hyperactivity: The effects of home-cage shavings and test chamber temperature

Prenatal ethanol exposure and spatial navigation: Effects of postnatal handling and aging

Effects of Mineralocorticoid and Glucocorticoid Receptor Blockade on Hypothalamic–Pituitary–Adrenal Function in Female Rats Prenatally Exposed to Ethanol

Contact Info

Product

Resources

About