Neonatal and juvenile stress induces changes in adult social behavior without affecting cognitive function

Tóth, É.; Avital, Avi; Leshem, Micah; Richter‐Levin, Gal; Braun, Katharina

doi:10.1016/j.bbr.2008.02.012

Cited by 49 publications

(37 citation statements)

References 45 publications

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“…The chronic-stressed mice also had reduced LTP in the CA1 pyramidal layer and reduced expression of several hippocampal proteins (e.g., synaptophysin and BDNF mRNA) compared to controls. Shorter stress exposures (one stressor/day postnatal days 28-30; 15 min swim, 30-min elevated platform, and 2 h restraint) altered behavioral and electrophysiological measures of hippocampal function compared to controls, but required exposure to new stressor in adulthood for effects to be found (Avital and Richter-Levin, 2005;Toth et al, 2008;Mag-gio and Segal, 2011). Repeated social defeat (postnatal days 35-39) altered hippocampal monoaminergic profiles in adulthood compared to controls (Watt et al, 2009).…”

Section: Discussionmentioning

confidence: 93%

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

McCormick¹,

Thomas²,

Sheridan³

et al. 2011

Hippocampus

105

127

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The ongoing development of the hippocampus in adolescence may be vulnerable to stressors. The effects of social instability stress (SS) in adolescence (daily 1 h isolation and change of cage partner postnatal days 30-45) on cell proliferation in the dentate gyrus (DG) in adolescence (on days 33 and 46, experiment 1) and in adulthood (experiment 2) was examined in Long Evans male rats and compared to nonstressed controls (CTL). Additionally, in experiment 2, a separate group of SS and CTL rats was tested on either a spatial (hippocampal-dependent) or nonspatial (nonhippocampal dependent) version of an object memory test and also were used to investigate hippocampal expression of markers of synaptic plasticity. No memory impairment was evident until the SS rats were adults, and the impairment was only on the spatial test. SS rats initially (postnatal day 33) had increased cell proliferation based on counts of Ki67 immunoreactive (ir) cells and greater survival of immature neurons based on counts of doublecortin ir cells on day 46 and in adulthood, irrespective of behavioral testing. Counts of microglia in the DG did not differ by stress group, but behavioral testing was associated with reduced microglia counts compared to nontested rats. As adults, SS and CTL rats did not differ in hippocampal expression of synaptophysin, but compared to CTL rats, SS rats had higher expression of basal calcium/calmodulin-dependent kinase II (CamKII), and lower expression of the phosphorylated CamKII subunit threonine 286, signaling molecules related to synaptic plasticity. The results are contrasted with those from previous reports of chronic stress in adult rats, and we conclude that adolescent stress alters the ongoing development of the hippocampus leading to impaired spatial memory in adulthood, highlighting the heightened vulnerability to stressors in adolescence.

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Section: Discussionmentioning

confidence: 93%

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

McCormick¹,

Thomas²,

Sheridan³

et al. 2011

Hippocampus

105

127

View full text Add to dashboard Cite

show abstract

“…For example, early life stress in rats has been shown to impair spatial learning in the water maze (Avital et al 2006;Avital and Richter-Levin 2005;Isgor et al 2004;Tsoory et al 2007), enhance startle reactivity (Avital et al 2006;Avital and Richter-Levin 2005;Bazak et al 2009;Cohen et al 2007;Maslova et al 2002;Tsoory et al 2007), reduce avoidance responses (Tsoory et al 2007;Tsoory and Richter-Levin 2006), reduce exploratory behaviour in a novel environment (Avital et al 2006;Avital and Richter-Levin 2005;Tsoory et al 2007;Tsoory and Richter-Levin 2006), and increase anxiety levels in the elevated plus maze (Avital et al 2006;Bazak et al 2009;Cohen et al 2007;Tsoory et al 2007). There have also been reports, however, showing no differences in exploratory behaviour (Toledo-Rodriguez and Sandi 2007;Toth et al 2008) or anxiety levels (Pohl et al 2007;Toledo-Rodriguez and Sandi 2007). Juvenile stress has not been found to affect cognitive function in adulthood (Toth et al 2008).…”

Section: Introductionmentioning

confidence: 94%

Differential effects of post-weaning juvenile stress on the behaviour of C57BL/6 mice in adolescence and adulthood

Peleg‐Raibstein

Feldon

2010

Psychopharmacology

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“…27,28) After performing openˆeld test, the social interaction test was performed in the same box. During the 10-min test, following and avoidance of two animals to each other was assessed and expressed in seconds.…”

Section: Social Interaction Testmentioning

confidence: 99%

Studies on Effect of Stress Preconditioning in Restrain Stress-induced Behavioral Alterations

2010

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Stress preconditioning has been documented to confer on gastroprotective eŠects on stress-induced gastric ulcerations. However, the eŠects of prior exposure of stress preconditioning episodes on stress-induced behavioral changes have not been explored yet. Therefore the present study was designed to investigate the ameliorative eŠects of stress preconditioning in immobilization stress-induced behavioral alterations in rats. The rats were subjected to restrain stress by placing in restrainer (5.5 cm in diameter and 18 cm in length) for 3.5 h. Stress preconditioning was induced by subjecting the rats to two cycles of restraint and restrain-free periods of 15 min each. Furthermore, a similar type of stress preconditioning was induced using diŠerent time cycles of 30 and 45 min. The extent and severity of the stress-induced behavioral alterations were assessed using diŠerent behavioral tests such as hole-board test, social interaction test, open eld test, and actophotometer. Restrain stress resulted in decrease in locomotor activity, frequency of head dips and rearing in hole board, line crossing and rearing in openˆeld, and decreased following and increased avoidance in social interaction test. Stress preconditioning with two cycles of 15, 30 or 45 min respectively, did not attenuate stress-induced behavioral changes to any extent. It may be concluded that stress preconditioning does not seem to confer any protective eŠect in modulating restrain stress-induced behavioral alterations.

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Neonatal and juvenile stress induces changes in adult social behavior without affecting cognitive function

Cited by 49 publications

References 45 publications

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

Differential effects of post-weaning juvenile stress on the behaviour of C57BL/6 mice in adolescence and adulthood

Studies on Effect of Stress Preconditioning in Restrain Stress-induced Behavioral Alterations

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