Abstract:Due to the inability of the immune systems of aged and neonatal humans and rodents to make sufficient Ab to the capsular polysaccharides (PS), they are susceptible to infections by PS encapsulated bacteria. This lack of anti‐PS Ab is due to MΦ not being able to produce B cell stimulatory cytokines. When stimulated by TLR agonists, murine neonatal and aged MΦ make less pro‐inflammatory cytokines (p‐ic) and more IL‐10 than adult MΦ. Neutralization of IL‐10 allowed them to produce levels of p‐ic comparable to tha… Show more
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