Neonatal and 5-Year Outcomes After Birth at 30–34 Weeks of Gestation

Abstract

Neonates born at 30-34 weeks experienced substantial morbidity and often required admission to neonatal intensive care units. These outcomes suggest that prolonging pregnancies beyond 34 weeks may be desirable whenever possible. Infants born at 30-34 weeks should be carefully monitored to ensure prompt detection and management of neurodevelopmental impairment.

Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis

“…Likewise, the incidence of both developmental disability and cerebral palsy is higher among children born prematurely. [108][109][110] As acknowledged by the GDG, the guideline models probably overestimate QALYs for these children. In addition, the models used utility scores derived by two different methods, TTO and EQ-5D.…”

“…The second study, EPIPAGE, 110 reported outcomes by gestational week, between 30 and 34 weeks, for births occurring in maternity units in nine French regions in 1997. The study enrolled 2467 infants.…”

“…those resulting from true-positive, false-positive or true-negative test results). Rather than vary the probability of admission using a CI derived from the data presented by the EPIPAGE study 110 (given the uncertainty involved in extrapolating from the EPIPAGE study 110 as it is a nearly 20-year-old study in a French population), we used the proportion of cases admitted to a NICU at the earliest birth week (30 weeks) and the proportion admitted at the latest birth week (34 weeks) in the EPIPAGE study as the lower and upper limits, respectively. Similarly, for a sensitivity analysis on duration of stay, the EAG has used the length of stay for cases admitted to a NICU at 30 weeks as the lower limit and the value at 34 weeks for the upper limit.…”

“…Median time to delivery (days) 9 3-16 PELICAN study 5 Onset of labour Spontaneous 0.000 Proportion of caesarean deliveries from the EPIPAGE study 110 (see Table 29). Absent further data, the EAG assumed all non-caesarean deliveries require induction a The distribution for mode of delivery was estimated from data reported for the PELICAN study.…”

Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta‐analysis

“…Although assisted ventilation and the introduction of surfactant therapy improved pediatric outcome in the 1990s, a baby born at 24 weeks' gestation still has only about a 50% chance of survival, and approximately more than one quarter of the survivors will have severe neurodevelopmental handicap 2,3 . The rates of perinatal death and severe handicap decline to 8% and 10% for babies born at 30 weeks and further reduce to 0.4% and 5% for those born at 34 weeks, respectively 4 .…”