Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood

Tachibana, Kaori; Hashimoto, Toshikazu; Kato, Rumiko; Uchida, Yoshiyuki; Ito, Ryoko; Takita, Kensuke; Morimoto, Yuji

doi:10.1111/j.1460-9592.2012.03810.x

Cited by 33 publications

(27 citation statements)

References 25 publications

(53 reference statements)

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“…The present study does not further characterize dexmedetomidine nor does it provide evidence that dexmedetomidine causes respiratory suppression because the animals received no other sedatives and because dexmedetomidine was administered at a dose higher than that used to achieve sedative effects in neonatal rats . Nonetheless, the present findings do indicate the functional effects of the α 2 ‐adrenoceptor on respiratory control in newborn rats.…”

Section: Discussionmentioning

confidence: 63%

Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats

Tamiya

Ide

Takahashi

et al. 2014

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 63%

Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats

Tamiya

Ide

Takahashi

et al. 2014

Pediatric Anesthesia

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“…This test is used in rodents for assessing spatial learning and memory. Three of these studies examined whether administration of dexmedetomidine alone causes impaired outcome . These studies showed that the outcome of the tests is worse after exposure to anesthetics compared to control.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and narrative synthesis on the histological and neurobehavioral long‐term effects of dexmedetomidine

Hoorn

Hoeks

Essink

et al. 2019

Pediatric Anesthesia

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SummaryBackgroundRecent experimental studies suggest that currently used anesthetics have neurotoxic effects on young animals. Clinical studies are increasingly publishing about the effects of anesthesia on the long‐term outcome, providing contradictory results. The selective alpha‐2 adrenergic receptor agonist dexmedetomidine has been suggested as an alternative nontoxic sedative agent.AimsThe aim of this systematic review was to assess the potential neuroprotective and neurobehavioral effects of dexmedetomidine in young animals and children.MethodsSystematic searches separately for preclinical and clinical studies were performed in Medline Ovid and Embase on February 14, 2018.ResultsThe initial search found preclinical (n = 661) and clinical (n = 240) studies. A total of 20 preclinical studies were included. None of the clinical studies met the predefined eligibility criteria. Histologic injury by dexmedetomidine was evaluated in 11 studies, and was confirmed in three of these studies (caspase‐3 activation or apoptosis). Decrease of injury caused by another anesthetic was evaluated in 16 studies and confirmed in 13 of these. Neurobehavioral tests were performed in seven out of the 20 studies. Of these seven rodent studies, three studies tested the effects of dexmedetomidine alone on neurobehavioral outcome in animals (younger than P21). All three studies found no negative effect of dexmedetomidine on the outcome. In six studies, outcome was evaluated when dexmedetomidine was administered following another anesthetic. Dexmedetomidine was found to lessen the negative effects of the anesthetic.ConclusionIn animals, dexmedetomidine was found not to induce histologic injury and to show a beneficial effect when administered with another anesthetic. No clinical results on the long‐term effects in children have been identified yet.

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“…The same holds true for future application of principles of pharmacovigilance studies. This is especially of interest since experimental studies have suggested that dexmedetomidine may have neuroprotective effects as well …”

Section: Discussionmentioning

confidence: 99%

“…This is especially of interest since experimental studies have suggested that dexmedetomidine may have neuroprotective effects as well. 106,107…”

Section: Discussionmentioning

confidence: 99%

Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long‐Term Neurodevelopment

Schiller

Allegaert

Hunfeld

et al. 2018

The Journal of Clinical Pharma

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Inadequate pain and/or stress management in preterm‐ and term‐born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy may also be one of the risk factors for subsequent neurodevelopmental impairment, at least in animal studies. Because infants admitted to neonatal or pediatric intensive care units may receive high amounts of these drugs for prolonged periods of time and the majority of these infants nowadays survive to discharge, this is of major concern. A balanced approach that incorporates the assessment and quantification of both wanted effects as well as unwanted side effects is therefore needed. In this article, the optimal dose determination of commonly used analgosedative drugs as well as their potential long‐term effects on the developing human brain and neuropsychological functioning are reviewed.

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Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood

Cited by 33 publications

References 25 publications

Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats

Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats

A systematic review and narrative synthesis on the histological and neurobehavioral long‐term effects of dexmedetomidine

Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long‐Term Neurodevelopment

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