Neonatal Acute Lymphoblastic Leukemia with t(9;11) Translocation Presenting as Blueberry Muffin Baby: Successful Treatment by ALL-BFM Induction Therapy, Allogeneic Stem Cell Transplantation from an Unrelated Donor, and PCR-MRD-Guided Post-Transplant Follow-Up

Schlegel, Simon; Hamm, Henning; Reichel, Andreas; Kneitz, Hermann; Ernestus, Karen; Andrés, Oliver; Wiegering, Verena; Eyrich, Matthias; Wölfl, Matthias; Schlegel, Paul‐Gerhardt

doi:10.12659/ajcr.927153

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Although a few cases of LC in T-ALL were reported in the literature from 1999 to 2021 (4,6,(8)(9)(10)(11), only one neonate has been described with a follow-up of 2 years after treatment, and no detailed records of treatment and follow-up in adult patients have been found (11). This case is the first described with a favorable evolution after a 3-year follow-up.…”

Section: Discussionmentioning

confidence: 89%

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Zhang

Wang

2023

Ann Palliat Med

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Herein, we report a case of a female patient with T-cell acute lymphoblastic leukemia (T-ALL) who presented with LC and was in excellent clinical condition during a 3-year follow-up after treatment with chemotherapy and allogeneic stem cell transplantation. We present the following case in accordance with the CARE reporting checklist (available at https://apm. amegroups.com/article/view/10.21037/apm-22-665/rc).

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Section: Discussionmentioning

confidence: 89%

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Zhang

Wang

2023

Ann Palliat Med

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“…A skin biopsy revealed dermal lymphoblastic infiltrates, which confirmed the diagnosis of neonatal ALL. 9 Additional unique presentations of leukemia cutis associated with T-ALL have been reported, including a case of erythematous papules and annular plaques, some with associated petechiae. 10 A widespread petechiae-like eruption in a patient with T-ALL, as seen in our patient, has not yet been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Profound leukemia cutis in a patient with relapsed T-cell acute lymphoblastic leukemia

Nohria

Criscito²,

Weston

et al. 2021

JAAD Case Reports

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“…The prognosis of LC in ALL is rather poor. However, in rare cases, longer survival was observed, especially after treatment with a combination of chemotherapy and allogeneic stem cell transplantation [25,110,112].…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.

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Neonatal Acute Lymphoblastic Leukemia with t(9;11) Translocation Presenting as Blueberry Muffin Baby: Successful Treatment by ALL-BFM Induction Therapy, Allogeneic Stem Cell Transplantation from an Unrelated Donor, and PCR-MRD-Guided Post-Transplant Follow-Up

Cited by 6 publications

References 21 publications

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Profound leukemia cutis in a patient with relapsed T-cell acute lymphoblastic leukemia

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

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