Neolithic introgression ofIL23R-related protection against chronic inflammatory bowel diseases in modern Europeans
Ben Krause-Kyora,
Nicolas Antonio da Silva,
Elif Kaplan
et al.
Abstract:SummaryBackgroundThe hypomorphic variant rs11209026-A in theIL23Rgene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.MethodsThis study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, the investigation focused on admixture informed analyses and selection scans of rs11209026-A and its haplotypes.Findingsrs11209026-A was found at high… Show more
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