NeoHeadHunter: an algorithm for the detection, ranking and probabilistic classification of neoepitope candidates
Xiaofei Zhao
Abstract:BackgroundThe manufacturing of personalized cancer vaccine requires the accurate identification of neoepitopes, abnormal peptides presented by cancer cells and recognized by the host immune system of the cancer patient.ResultsWe designed and developed NeoHeadHunter, a computational algorithm and pipeline to detect and rank neoepitope candidates. Unlike other algorithms, NeoHeadHunter can estimate the probability that each predicted neoepitope candidate is true positive. To evaluate NeoHeadHunter, we used the T… Show more
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