Neoglycosylated liposomes as efficient ligands for the evaluation of specific sugar receptors on macrophages in health and in experimental leishmaniasis

Dutta, Madhuri; Bandyopadhyay, Rajyasree; Basu, Madhumita

doi:10.1017/s0031182000076253

Cited by 27 publications

(4 citation statements)

References 25 publications

(13 reference statements)

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“…As the entire lifecycle of lice is completed within one host, population of lice can be rapidly established once they come into contact with a suitable host. Spreading of lice to other animals within same herd is not uncommon as the transmission of lice can be achieved through close proximity contact ( Hart 1994 ).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Ectoparasitism on Small Ruminants in Kelantan, Malaysia

Syamsul

Okene

Yahya

et al. 2020

TLSR

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Highlights• 60% of the sampled animals were infested with at least one species of the ectoparasites.• Lice and ticks were the most prevalent ectoparasites on small ruminant, which were 43.64% and 22.98% respectively.• The prevalence of ectoparasites on small ruminant is significantly higher at inland region.Abstract: Kelantan is a chiefly agrarian state with abundant small-holder ruminant farms in the East Coast economic Region of Malaysia. Ectoparasitism affects small ruminant production in Malaysia. It often causes reduction in meat quality and milk production which affect the farmers' income. To date, no report for the prevalence of ectoparasitism on small ruminant in Kelantan compared to other state in Malaysia. This study aims to determine the prevalence and associated risk factor of ruminant ectoparasitism in Kelantan. Ectoparasites were collected by manual picking and skin scrapping from 462 sheep and goats in Kelantan between April and September 2017 (during dry season). 60% of the sampled animals were infested with at least one species of the ectoparasites. In this study, lice and ticks were the most prevalent ectoparasites on small ruminant, which were 43.64% and 22.98%, respectively. The high biotic potential of lice population on host might be one of the factors they become the most prevalent species found on the animals. There was no significant relationship between ectoparasitism prevalence and species of small ruminants (χ 2 = 1.12, p = 0.293). However, there was significant variations in prevalence between the regions where the animals were sampled from (χ 2 = 30.25, p = 0.002) and farm management system for both species. This present study provides baseline epidemiological data on the prevalence of ectoparasitism in small ruminant. This information is useful for the formulation of prevention and control measures in order to enhance ruminant productivity in Kelantan.Abstrak: Kelantan adalah negeri agraria di kawasan ekonomi Pantai Timur Malaysia dengan kebanyakan penternak mempunyai ladang ruminan yang kecil. Ektoparasit menjejaskan pengeluaran ruminan kecil di Malaysia. Ia menyebabkan penghasilan kualiti daging yang rendah dan kurang penghasilan susu yang menjejaskan sumber pendapatan penternak. Buat masa ini, tiada laporan mengenai prevalens ektoparasitisme pada ruminan kecil di Kelantan jika dibandingkan dengan negeri-negeri lain di Malaysia. Kajian ini bertujuan

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Section: Resultsmentioning

confidence: 99%

Prevalence of Ectoparasitism on Small Ruminants in Kelantan, Malaysia

Syamsul

Okene

Yahya

et al. 2020

TLSR

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“…Τα δυο μόρια καλύπτουν τη μεγαλύτερη επιφάνεια των προμαστιγωτών μορφών και είναι υπεύθυνα για την πρόσδεση των προμαστιγω τών στα μακροφάγα. Η γλυκοπρωτεϊνη με μοριακό βάρος 63 kd (gp63) περιέχει μαννόζη, Ν-ακετυλογλυκο-ζαμίνη και Ν-ακετυλογαλακτοζαμίνη και μπορεί να αλληλεπιδρά με τον υποδοχέα του συμπληρώματος και με τον υποδοχέα της μαννόζης-φουκόζης των μακροφά γων, ανεξάρτητα από την παρουσία ή μη οροΰ 21 . Η απο δεδειγμένη ανασταλτική δράση της σινεφουνγίνης στη σύνθεση του DNA των πρωτόζωων που έχουν υψηλό βαθμό ευαισθησίας 22 , ίσως συνδέεται με την έκφραση των άνω γλυκοπρωτεϊνών σε μικρότερες ποσότητες στην εξωτερική μεμβράνη του πρωτόζωου.…”

Section: συζητησηunclassified

Effect of Sinefungin on the attachment of the parasite Leishmania to the macrophages cell line J774G8

Tzora

Lawrence

Robert-Géro

2018

J Hellenic Vet Med Soc

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The effect of Sinefungin on the attachment of the Leishmania strains L. infantum, L. tropica and L. major to the macrophages cell line J774G8 was studied. Inhibition ofthe attachment to the surface of macrophages was observed to the Sinefungin sensitive strains L. tropica and L. major. This inhibition was obtained only for Sinefungin pretreated promastigotes (72 hours with 2.6 and 26 Μμ Sinefungin) when incubated with macrophages for 2 and 24 hours. After 2 h incubation period of the promastigote forms of the sensitive L. tropica with macrophages, the inhibition of the attachment was 100%, whereas for the sensitive L. major strain the inhibition was 17 and 36% at a concentration of Sinefungin 2.6 and 26 μΜ respectively. The percentage of the inhibition 24 h post infection was in the range of 52 to 77% for the L. tropica strain and from 73 to 86% for the L. major strain for promastigote pretreated with 2.6 and 26 μΜ Sinefungin respectively. Controls showed that Sinefungin was not toxic for the macrophages when used for 3 days at the above mentioned concentrations. Inhibition of the protozoa - macrophage cell line J774G8 adherence was a common finding leading us to the conclusion that Sinefungin is involved actively into that process.

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“…These receptors were associated mainly to L. (L.) donovani in vivo clearence from the blood [60] and may be relevant to recognition in the hepatic environment during the early stages of infection. Kuppfer cells in infected mice present a decrease in the number of receptors as assessed by the use of mannose-bearing liposomes [103] and 125 I-labelled-mannose-BSA [22]. The major ligand of MFR may be gp63 [226].…”

Section: Promastigote Interaction With Host Cellsmentioning

confidence: 99%

Leishmania-Host Interplay: The Everlasting Rivalry

Martiny¹,

Vannier-Santos²

2005

MCRO

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Parasitic protozoa of the genus Leishmania infect mammalian mononuclear phagocytic cells causing a potentially fatal disease with a broad spectrum of clinical manifestations. The drugs of choice used in the leishmaniasis therapy are significantly toxic, expensive and faced with a growing frequency of refractory infections. Thus the search for new leishmanicidal compounds is urgently required. In order to perform a proper drug design and to understand the modes of action of such compounds it is necessary to elucidade the intrincate cellular and molecular events that orchestrate the parasite biology. To invade host cells Leishmania recruit different surface receptors that may assist engaging the microbicidal responses. Even before gaining the intracellular millieu these pathogens can deactivate and/or subvert the phagocyte signal transduction machinery rendering these cells permissive to infection. In the present review we attempted to approach some of the most relevant cellular and biochemical invasion strategies employed by Leishmania parasites.

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Neoglycosylated liposomes as efficient ligands for the evaluation of specific sugar receptors on macrophages in health and in experimental leishmaniasis

Cited by 27 publications

References 25 publications

Prevalence of Ectoparasitism on Small Ruminants in Kelantan, Malaysia

Prevalence of Ectoparasitism on Small Ruminants in Kelantan, Malaysia

Effect of Sinefungin on the attachment of the parasite Leishmania to the macrophages cell line J774G8

Leishmania-Host Interplay: The Everlasting Rivalry

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