Neoglycolipid Conjugates of Foscarnet with Enhanced Antiviral Activity in Cells Infected with Human Cytomegalovirus and Herpes Simplex Virus Type 1

Abstract

The synthesis of a series of neoglycolipid conjugates of foscarnet as potential drug targeting forms or lipophilic prodrugs of foscarnet is described. The compounds were obtained from suitably protected neoglycolipids, in which the lipid chain consisted of 12 to 20 carbon atoms, by ethoxycarbonylphosphonylation at the 6-hydroxyl or 4-hydroxyl group followed by deprotection.