Neoangiogenesis and expression of hypoxia-inducible factor 1α, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas

Özbudak, İrem Hicran; Karaveli, Şeyda; Şimşek, Tayyup; Erdoğan, Gülgün; Peştereli, Elif

doi:10.1016/j.ygyno.2007.11.028

Cited by 45 publications

(35 citation statements)

References 16 publications

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“…Our study showed no significant difference in HIF-1α expression between various stages of endometrial adenocarcinoma. In the literature, the association of stage and HIF-1α expression was investigated (19 high expression in advanced stages of endometrioid adenocarcinoma (22). Increased HIF-1α expression is associated with aggressive tumor behaviour and ability to metastasize.…”

Section: Discussionmentioning

confidence: 99%

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

Aybatli¹,

Sayın²,

Kaplan³

et al. 2012

J Turkish German Gynecol Assoc

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Objective: Hypoxia inducible factor 1 alpha (HIF-1α) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia. The aim of this study was to determine tumoral angiogenesis with immunohistochemical markers in endometrium cancer and its relation with stage, grade, survival rates and other prognostic factors. Material and Methods:Using the database in our Gynecologic Oncology clinic, we selected 94 patients who were diagnosed with endometrial cancer and underwent primary surgery at our institution between 2001 and 2010. Tissue microarrays believed to demonstrate the optimum part of the tumor were reprepared from the paraffin blocks. Angiogenesis and microvessel density (MVD) were investigated with the aid of HIF-1α and CD34 antibodies.Results: High expression of HIF-1α was significantly more frequent in advanced grade endometrial cancers (p=0.044). HIF-1α expression was highly correlated with CD34 expression in the tumor cells (p<0.001). However lack of relation among stage, overall survival rates and histological types were analyzed with HIF-1α. When we compared HIF-1α positive and negative cases with cervical, adnexial, lymphovascular and myometrial invasion, there was no difference between these groups. MVD was evaluated with CD34 and it was remarkable and significantly different on advanced grade tumors (r=0.268; p=0.009). A similar significant difference was observed between the high expression of CD34 and type II endometrial cancer histology (p<0.001). However, there was no relationship between the MVD and stage or survival rates. Conclusion:High expression of HIF-1α is associated with tumoral angiogenesis in endometrial adenocarcinomas. Further studies targeting HIF-1α for disrupting mechanisms essential for tumor growth in endometrium cancer will be significant investigations in the future. (J Turkish-German Gynecol Assoc 2012; 13: 37-44) Key words: Endometrium cancer, HIF-1α, hypoxia, angiogenesis Received: 21 April, 2011 Accepted: 3 December, 2011 Amaç: Hipoksi ile indüklenen faktör-1α (HIF-1 α) bir nükleer proteindir ve azalan hücre içi oksijen konsantrasyonuna cevap olarak regüle edilir. Bu nedenle bir hipoksi belirteci gibi görev yapar. Bu çalışmanın amacı endometrium kanserli olgularda tümör anjiogenezini immunohistokimyasal belirteçler ile incelemek ve evre, derece ve sağkalım gibi prognostik faktörlerle olan bağlantısını aydınlatmaya çalışmaktır.

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Section: Discussionmentioning

confidence: 99%

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

Aybatli¹,

Sayın²,

Kaplan³

et al. 2012

J Turkish German Gynecol Assoc

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“…Novel techniques for the delivery of radiation, including intensity-modulated radiation therapy and tomotherapy are promising technologies to improve the therapeutic index for patients receiving combined therapy [Lian, 2008;Salama, 2006;Beriwal, 2006]. A number of trials are ongoing to examine novel biologic and target therapies for women with endometrial cancer [Konecny, 2008;Kamat, 2007;Wright, 2007;Ozbudak, 2008;Morrison, 2006]. Systemic treatment for metastatic and relapsed disease may consist of endocrine therapy or cytotoxic chemotherapy.…”

Section: Treatment Of Localized Diseasementioning

confidence: 99%

Prevention and Therapeutic Strategies in Endometrial Cancer

Ancua¹,

Furu²,

Carabineanu³

et al. 2012

Cancer Prevention - From Mechanisms to Translational Benefits

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“…26,27 In this respect, hypoxia-inducible factor 1 (HIF-1) plays a key role in the adaptation of neoplastic cells to hypoxia by promoting transcriptional activation of a repertoire of genes, such as those encoding GLUT-1 and vascular endothelial growth factor (VEGF). 22,26,37 The latter has been described as an important proangiogenic factor both under physiological and pathological conditions. 23,37 Taken together, the results reported herein emphasize the important relationship between hypoxia, glucose uptake into the intracellular medium, and angiogenesis, particularly in tumors.…”

mentioning

confidence: 99%

“…22,26,37 The latter has been described as an important proangiogenic factor both under physiological and pathological conditions. 23,37 Taken together, the results reported herein emphasize the important relationship between hypoxia, glucose uptake into the intracellular medium, and angiogenesis, particularly in tumors. In agreement with this suggestion, studies on endometrial adenocarcinomas and ovarian carcinomas have shown a positive correlation between GLUT-1 expression and microvessel density in the tumors.…”

mentioning

confidence: 99%

“…In agreement with this suggestion, studies on endometrial adenocarcinomas and ovarian carcinomas have shown a positive correlation between GLUT-1 expression and microvessel density in the tumors. 37,38 On the other hand, Kitamura et al 39 reported an inverse correlation between tumor glycolytic metabolism and angiogenesis in hepatocellular carcinomas. Kubo et al 40 observed an association between GLUT-1 immunoexpression and low microvessel density in osteosarcomas and questioned the relationship between glycolytic metabolism and angiogenesis in some malignant tumors.…”

mentioning

confidence: 99%

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Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors

et al. 2017

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Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors Abstract: The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count. The results were analyzed statistically using the nonparametric Kruskal-Wallis test and Spearman's correlation test. High epithelial immunoexpression of GLUT-1 was observed in most tumors (p = 0.360). There was a higher frequency of negative cases for GLUT-3 in all groups. The few GLUT-3-positive tumors exhibited low expression of this protein in epithelial cells. No significant difference in the angiogenic index was observed between groups (p = 0.778). GLUT-1 expression did not correlate significantly with the angiogenic index (p > 0.05). The results suggest that the more aggressive biological behavior of SKOTs when compared to NSKOTs may not be related to GLUT-1 or GLUT-3 expression. GLUT-1 may play an important role in glucose uptake by epithelial cells of KOTs and this process is unlikely related to the angiogenic index. GLUT-1 could be a potential target for future development of therapeutic strategies for KOTs.

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Neoangiogenesis and expression of hypoxia-inducible factor 1α, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas

Cited by 45 publications

References 16 publications

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

Prevention and Therapeutic Strategies in Endometrial Cancer

Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors

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