Neoagarotetraose protects mice against intense exercise‐induced fatigue damage by modulating gut microbial composition and function

Zhang, Na; Mao, Xiangzhao; Li, Robert W.; Hou, Enling; Wang, Yuming; Xue, Changhu; Tang, Qingjuan

doi:10.1002/mnfr.201600585

Cited by 75 publications

(37 citation statements)

References 34 publications

(39 reference statements)

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“…These results were in line with the literature, indicating that 4 weeks exhausted swimming relatively suppressed the process of carbohydrate hydrolysis and absorption, resulting in elevated protein digestion and absorption in the small intestine to obtain more protein for the repairmen of exercise‐induced muscle injury . Studies have reported that 16 days intense exercise using wheel‐track treadmill in male Balb/c mice damaged the integrity of the histomorphology of the intestinal mucosa, while our histology results showed that there were no obvious pathological changes in small intestine and colon after 4 weeks exhaustion swimming. This difference may be due to the different exercise method and different mice type.…”

Section: Discussionsupporting

confidence: 92%

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Yuan

Huang

et al. 2018

Scandinavian Med Sci Sports

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The purpose of this study was to evaluate the negative influence of excessive exercise on immunity, substance and energy metabolism as well as gut microbiota in mice. Firstly, an overtraining model of Male Kunming mice was established by high-intensity swimming exercise for 4 weeks. Then, a series of evaluation indicators, including the routine blood analysis, immune organ coefficient, digestive enzymes, and aquaporins expression levels of small intestine and colon tissue, histological examinations of liver, spleen, small intestine, and colon, were determined based on this model. Furthermore, 16S rRNA gene sequencing was also employed to measure the microbial composition in gut. The results found that immune parameters, substance and energy metabolism of all mice was altered and disturbed after high-intensity swimming for 4 weeks, led to an atrophy of thymus and spleen as well as abnormal structural changes in liver when compared to non-swimming mice. Besides, excessive swimming mice had lower microbial diversity compared to non-swimming mice. However, there was no significant difference in gut microbial taxa between the two groups. The data indicated that excessive exercise exhibits negative impacts on immunity, substance and energy metabolism as well as gut microbial diversity.

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Section: Discussionsupporting

confidence: 92%

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Yuan

Huang

et al. 2018

Scandinavian Med Sci Sports

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“…The concentration of each extracted RNA sample was determined using a Nano Drop 2000 Spectrophotometer (Thermo, USA), and the integrity of the RNA was checked using denatured RNA electrophoresis. Real-time qPCR was performed according to the method of Zhang et al [67]. The primers were synthesized by Shanghai Sangon Gene Company (Qingdao, China) and the sequences are listed in Table S3.…”

Section: Real-time Qpcrmentioning

confidence: 99%

Astaxanthin n-Octanoic Acid Diester Ameliorates Insulin Resistance and Modulates Gut Microbiota in High-Fat and High-Sucrose Diet-Fed Mice

Gao

Yang

Chin

et al. 2020

IJMS

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Astaxanthin n-octanoic acid diester (AOD) is a type of astaxanthin connecting medium-chain fatty acids with a more stable structure. In this study, we examined the role of AOD in ameliorating insulin resistance (IR) induced by a high-fat and high-sucrose diet (HFD) as well as its effect on modulating gut microbiota in mice, with free astaxanthin (AST) as a comparison. Four groups of male C57BL/6J mice (6 weeks old; n = 10 per group) were fed with a normal control diet (NC), HFD orally administered with AOD, AST (50 mg/kg body weight), or vehicle for 8 weeks. AOD improved glucose tolerance, IR, systematic and intestinal inflammation, and intestinal integrity better than AST. Further, both AOD and AST modulated gut microbiota. A significantly higher abundance of Bacteroides and Coprococcus was found in AOD than in AST, and the predicted pathway of carbohydrate metabolism was significantly impacted by AOD. Overall, AOD may play a role in alleviating IR and inflammation with the modulating effect on microbiota in HFD-fed mice. Our findings could facilitate the development of AOD as a bioactive nutraceutical and more stable alternative to AST.

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“…These results suggested that K. alvarezii might have the potential as a prebiotic ingredient. A study published by Zhang et al [110] focused on the beneficial effect of low-melting-point agarose (in the form of neoagaro-oligosaccharides) on the GM during the relief of intense exercise-induced fatigue in mice. Results showed the abundance of Bacteroidetes and Proteobacteria increased and decreased, respectively, during the attenuation of fatigue and its associated gastrointestinal problems.…”

Section: Polysaccharides From Red Seaweedsmentioning

confidence: 99%

“…Prevotella is another beneficial genus with the potential to participate in the metabolism and utilization of plant polysaccharides. The genus Phascolarctobacterium is associated with the production of SCFA [110].…”

Section: Polysaccharides From Red Seaweedsmentioning

confidence: 99%

Potential Use of Marine Seaweeds as Prebiotics: A Review

et al. 2020

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Human gut microbiota plays an important role in several metabolic processes and human diseases. Various dietary factors, including complex carbohydrates, such as polysaccharides, provide abundant nutrients and substrates for microbial metabolism in the gut, affecting the members and their functionality. Nowadays, the main sources of complex carbohydrates destined for human consumption are terrestrial plants. However, fresh water is an increasingly scarce commodity and world agricultural productivity is in a persistent decline, thus demanding the exploration of other sources of complex carbohydrates. As an interesting option, marine seaweeds show rapid growth and do not require arable land, fresh water or fertilizers. The present review offers an objective perspective of the current knowledge surrounding the impacts of seaweeds and their derived polysaccharides on the human microbiome and the profound need for more in-depth investigations into this topic. Animal experiments and in vitro colonic-simulating trials investigating the effects of seaweed ingestion on human gut microbiota are discussed.

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Neoagarotetraose protects mice against intense exercise‐induced fatigue damage by modulating gut microbial composition and function

Abstract: Together, our findings suggest that NAT may protect mice against intense exercise-induced fatigue and provide insights into the mechanisms of NAT as a potential prebiotic.

Cited by 75 publications

References 34 publications

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Astaxanthin n-Octanoic Acid Diester Ameliorates Insulin Resistance and Modulates Gut Microbiota in High-Fat and High-Sucrose Diet-Fed Mice

Potential Use of Marine Seaweeds as Prebiotics: A Review

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