Neoadjuvant proton beam irradiation followed by transscleral resection of uveal melanoma in 106 cases

Willerding, G; Cordini, Dino; Moser, Lutz; Krause, Lothar; Foerster, Michael; Bechrakis, Nikolaos E.

doi:10.1136/bjophthalmol-2015-307095

Cited by 18 publications

(11 citation statements)

References 21 publications

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“…Local resection of the tumor can be carried out either by a transretinal (endoresection) or transscleral (exoresection) approach [79,80]. Local resection is used to remove select (typically medium sized or large) uveal melanoma with retention of the eye [81].…”

Section: Surgerymentioning

confidence: 99%

Uveal melanoma: physiopathology and new in situ-specific therapies

Souto

Zielińska

Luís

et al. 2019

Cancer Chemother Pharmacol

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Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e.g., GNAQ/GNA11; BAP1), which are considered promising targets for molecular therapy. Primary treatment of uveal melanoma includes radiotherapy (brachytherapy and charged-particle therapy), phototherapy (photocoagulation, transpupillary thermal therapy, and photodynamic therapy) and surgery (local resection, enucleation and exenteration). Approximately half of patients with uveal melanoma will, however, develop metastasis, especially in the liver. The treatment of metastatic uveal melanoma includes systemic chemotherapy, immunotherapy and molecular targeted therapy. Liver-directed therapies, such as resection, chemoembolization, immunoembolization, radioembolization, isolated hepatic perfusion and percutaneous hepatic perfusion, are also available to treat metastatic uveal melanoma. Several clinical trials are being developed to study new therapeutic options to treat uveal melanoma, mainly for those with identified liver metastases. The present work discusses the physiopathology and new in situ-specific therapies for the treatment of uveal melanoma.

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Section: Surgerymentioning

confidence: 99%

Uveal melanoma: physiopathology and new in situ-specific therapies

Souto

Zielińska

Luís

et al. 2019

Cancer Chemother Pharmacol

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“…Отмечено увеличение (практически в два раза) частоты осложнений по мере удлинения сроков наблюдения с 3 до 5 лет. Такая же закономерность наблюдается в отношении вторичной энуклеации и метастазирования [63]. Частота рецидивов связана с тем, что большие МХ агрессивно внедряются в окружающие ткани.…”

Section: хирургические методы леченияunclassified

Local treatment of choroidal melanoma: possibilities and limitations

Brovkina¹

2018

Vestn. oftal'mol.

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Local treatment of choroidal melanoma (CM) attracts the attention of many ophthalmology specialists, especially in recent years as the capabilities to target irradiation at small objects and possibilities of surgical interventions on the eyeball have expanded. The article discusses the medical indications for local treatment of CM. Review of literature of the last 16 years and author's own observations on CM patients who underwent almost all kinds of conventional methods of local treatment allowed thorough analysis of indications and counter-indications for their usage. Among the authors who favor local destruction and removal of large CM, the main indication is the possibility to preserve vision and anatomical structures of the eye. This led to unreasonably wide spread of local destruction (removal) of large CM, primarily the endovitreal resection method. However, such metastasis risk factors as CM size and its localization are being overlooked. Literature analysis and author's own observations helped validate the unsafety of the local treatment of large CM. The article features long-term results of contact and distant radiation therapy, and presents CM metrics for best therapeutic effect.

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“…Hintergrund Bis in die Mitte des vorigen Jahrhunderts war die Enukleation die einzige therapeutische Option für die Behandlung des uvealen Melanoms. Aufgrund der Radikalität dieses Vorgehens wurden bulbuserhaltende Resektionstechniken, die auf Erfahrungen aus der Traumachirurgie basierten, zunächst von Stallard in England und Müller in Deutschland sowie später von Naumann entwickelt [13][14][15][16][17][18][19][20]. Da diese Techniken vielversprechende Ergebnisse hinsichtlich des Bulbuserhalts und der lokalen Tumorkontrolle zeigten, wurden sie von Foulds und später Damato weiter verfeinert (wie z.…”

Section: Transsklerale Resektionunclassified

Chirurgische Methoden in der Behandlung des Aderhautmelanoms

Blatsios

Haas

Zehetner

et al. 2017

Klin Monatsbl Augenheilkd

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Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular therapy for uveal melanoma either to treat/prevent radiation complications, such as so-called toxic tumour syndrome, or to primarily treat the tumour with or without adjunctive radiotherapy. These include endoresection and transscleral resection for melanomas of the choroid/ciliary body or irido-trabeculo-cyclectomy for melanomas of the iris-ciliary body. Furthermore, tumour biopsy is playing a progressively more important role in the diagnosis, treatment and follow-up planning of melanoma cases. This paper focuses on the background, the surgical technique as well as the results and complications of tumour excisional and biopsy surgery.

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Neoadjuvant proton beam irradiation followed by transscleral resection of uveal melanoma in 106 cases

Abstract: Neoadjuvant proton beam irradiation may help to prevent local recurrence after transscleral resection. Additional vitreoretinal surgery was frequently needed in the presented series. The majority of patients avoided enucleation and functional blindness.

Cited by 18 publications

References 21 publications

Uveal melanoma: physiopathology and new in situ-specific therapies

Uveal melanoma: physiopathology and new in situ-specific therapies

Local treatment of choroidal melanoma: possibilities and limitations

Chirurgische Methoden in der Behandlung des Aderhautmelanoms

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