Neoadjuvant Immunotherapy Plus Chemotherapy and Adjuvant Targeted Therapy in
            <i>ALK</i>
            -Positive Non-Small-Cell Lung Cancer

Song, Quansheng; Li, Jie; Xiong, Qi; Long, Yiwen; Yang, Bo; Dong, Zhong‐Yi; Liang, Chunyang; Yang, Bo

doi:10.2217/imt-2022-0302

Cited by 2 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concurrent chemoradiotherapy is the standard treatment plan. About 9% of patients progress during treatment, and 41% progress after treatment, resulting in a poor long-term prognosis (29)(30)(31). To augment the life expectancy of patients presently grappling with NSCLC, there has been a paradigm shift in contemporary clinical interventions toward a strategy that synergizes chemoradiotherapy with PD-1/PD-L1 inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study

Cao,

Ye,

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveTo compare the therapeutic effects and adverse reactions of sterilizing rare earth carbonate combined with concurrent chemoradiotherapy and simple concurrent chemoradiotherapy in the treatment of late-stage non-small cell lung cancer (NSCLC), and to analyze the reasons for the differences.MethodA total of 817 patients with pathologically diagnosed late-stage NSCLC from June 1, 2021 to December 30, 2022, in the affiliated hospital of Kunming University of Science and Technology, were selected. They were randomly divided into a control group of 394 people and an experimental group of 423 people. The control group was given concurrent chemoradiotherapy (cisplatin + etoposide), while the experimental group simultaneously took a low dose of sterilized rare earth carbonate (0.05mg/Kg). The χ² test and Fisher’s test were used to compare the clinical pathological features, objective response rate (ORR), ECOG score, and adverse reactions of the two groups of patients, while survival analysis was used to compare the progression-free survival (PFS) of the two groups. Cox regression analysis was used to test factors related to prognosis.ResultsThe differences in clinical pathological features between the two groups of patients were not statistically significant, with all P>0.05. The ORR of the control group was 45.18% (178/394), and the experimental group was 89.83% (380/423), with a statistically significant difference (P=0.001). After treatment, the ECOG score of the experimental group was lower than that of the control group, P<0.001. The adverse reaction grading of patients in both groups was below level 3 after treatment, and no treatment-related fatalities occurred. The risk of pulmonary infection and bone marrow suppression in the experimental group was lower than that in the control group.ConclusionIn late-stage NSCLC patients, compared with simple concurrent chemoradiotherapy, the combination of concurrent chemoradiotherapy and sterilizing rare earth carbonate can significantly improve the short-term therapeutic effect and prognosis of patients, with good safety.

show abstract

Section: Discussionmentioning

confidence: 99%