Neoadjuvant Immunotherapy and Intestinal Microbiota: Unraveling Their Roles in Anastomotic Leakage and Fistula After Colorectal Cancer Surgery
Irami Araújo-Filho
Abstract:This comprehensive review explores the multifaceted relationship between neoadjuvant immunotherapy, intestinal microbiota alterations, and anastomotic leakage risk in patients undergoing colectomy for colon neoplasia. With the advent of immunotherapy, remarkably immune checkpoint inhibitors, there has been a significant shift in the treatment paradigms for various cancers, including colon neoplasia. These treatments, while effective, have been associated with changes in the intestinal microbiome, which, in tur… Show more
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