Neoadjuvant chemotherapy with paclitaxel and carboplatin followed by definitive chemoradiation in locally advanced cervical carcinoma. Experience of a cancer hospital in Pakistan
Abstract:To report the efficacy and toxicity of neoadjuvant chemotherapy (NACT) before standard concurrent chemo radiation (CCRT) in locally advanced carcinoma of cervix. Methods: Between January 2007 and December 2016, 75 patients with locally advanced cervical cancer treated with neoadjuvant chemotherapy comprising carboplatin area under curve (AUC) 5 and Paclitaxel 175 mg/m 2 followed by chemo radiotherapy 45-59 Gy in 25-28 fractions with concurrent cisplatin and high dose rate (HDR) brachytherapy at our institution… Show more
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