Neoadjuvant Chemotherapy in the Treatment of Breast Cancer

Redden, Meredith; Fuhrman, George M.

doi:10.1016/j.suc.2013.01.006

Cited by 58 publications

(34 citation statements)

References 22 publications

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“…We excluded patients who had received neoadjuvant chemotherapy when analyzing the association between ambient PM and tumor characteristics, including histological grade, tumor size, lymph node metastasis and hormonal receptor status, as neoadjuvant chemotherapy may affect these characteristics prior to surgery or pathological examination and because the non-invasive patients did not receive neoadjuvant therapy [9], [10]. To confirm that the results reflected the long-term, rather than short-term, effects of air pollution on breast cancer patients, we further assessed our data by controlling for patient age at the time of diagnosis.…”

Section: Methodsmentioning

confidence: 99%

Effects of Ambient Particulate Matter on Human Breast Cancer: Is Xenogenesis Responsible?

et al. 2013

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BackgroundRecently, evidence from several studies has revealed that air pollution is associated with the increased morbidity and mortality of breast cancer patients. However, to date, the underlying mechanism remains largely unclear. Considering the high prevalence of air pollution and breast cancer in China, it is necessary to understand how air pollution may affect breast cancer.MethodsWe analyzed 1,832 female patients who had resided in the same cities for at least 10 years prior to their diagnosis. Variables including demographic data as well as clinical and tumor characteristics, including the patient’s age at menarche, family history of breast cancer, tumor histopathological type, tumor size, lymph node metastasis, distant metastasis, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status and human epidermal growth factor receptor 2 (HER-2) status at the time of diagnosis were analyzed.ResultsCompared to patients residing in low-pollution areas, patients living in high-pollution areas demonstrated a younger age at menarche (p<0.001), a greater family history of breast cancer (p = 0.034) and more invasive cancers (p = 0.028) with higher tumor grades (p = 0.028) and estrogen receptor (ER)-positive status (p = 0.022). Differences in tumor grade were only found in ER-positive cases.ConclusionsOur findings and clinical data indicate that long-term air pollution exposure may contribute to the development of breast cancer by playing the role of a xenoestrogen, and also provides new insight into the association between air pollution and the morbidity and mortality of breast cancer patients. Furthermore, it is urgently necessary to study the association between air pollution and breast cancer to improve the living quality and health of females, and applicable public health strategies may need to be established or modified as soon as possible.

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Section: Methodsmentioning

confidence: 99%

Effects of Ambient Particulate Matter on Human Breast Cancer: Is Xenogenesis Responsible?

et al. 2013

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“…In addition, it is increasingly applied also in patients with operable breast cancer to monitor the clinical efficacy of systemic treatment (1)(2)(3). More recently, it has been proposed to use neoadjuvant induction chemotherapy to use pathologic response (presence or absence of pathologic complete response [PCR]) for further treatment stratification (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer: Influence of Taxanes on Response Assessment with Dynamic Contrast-enhanced MR Imaging

Schrading¹,

Kuhl²

2015

Radiology

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The reduction of enhancement observed in breast cancers after T-NACT is, in part, unrelated to their oncologic response. MR imaging-detectable effects of taxanes represent a combination of specific antimitotic and nonspecific antiangiogenic effects. This impacts the accuracy with which dynamic contrast-enhanced MR imaging helps predict complete pathologic response to T-NACT. (©) RSNA, 2015 Online supplemental material is available for this article.

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“…According to the National Cancer Registry 2007 of Malaysia, breast and colorectal cancer also are the most common cancer in Malaysia [48]. One of the main treatments for cancer is chemotherapy [49,50]; however, the development of drug resistance [51,52] and drug toxicity [53] results in significant relapse as well as decreased overall survival rates in cancer patients [54]. us, searching for potential drug with high efficacy and low drug toxicity remains a huge challenge in the anticancer drug discovery research and development.…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

Sofyan

Nordin

Razak

et al. 2018

Journal of Chemistry

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Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. e structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier transformed infrared (FTIR), 1 H, 13 C, and 31 P{ 1 H} NMR spectroscopy, and thermogravimetric analysis (TGA). A bidentate phosphine ligand acted as a chelating agent which bond to the silver in 1 : 2 molar ratios. Meanwhile, thiazolidine was attached to the silver in a 1 : 1 molar ratio. e antiplasmodial properties of all synthesized complexes were investigated on chloroquine-resistant P. falciparum parasite via HRP2 assays and cytotoxicity tests on Vero cells. Of all the synthesized complexes, complex 2 showed the highest SI value (more than 12.4) followed by complex 5 (6.6). e potent properties of compounds 2 and 5 were also noted in the in vitro antiproliferative assays involving MDA-MB-231 and MCF-7 breast cancer cell lines as well as HT-29 colon cancer cell line. Complex 2 was selective for MDA-MB-231 cells (GI 50 � 1.9 ± 0.3 µM), while complex 5 acted predominantly on breast carcinoma cells (GI 50 MDA-MB-231 � 4.7 ± 1.1 µM; MCF-7 � 2.9 ± 0.9 µM) instead of colon carcinoma (HT-29) cells (GI 50 � 15.1 ± 1.9 µM).

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Neoadjuvant Chemotherapy in the Treatment of Breast Cancer

Cited by 58 publications

References 22 publications

Effects of Ambient Particulate Matter on Human Breast Cancer: Is Xenogenesis Responsible?

Effects of Ambient Particulate Matter on Human Breast Cancer: Is Xenogenesis Responsible?

Breast Cancer: Influence of Taxanes on Response Assessment with Dynamic Contrast-enhanced MR Imaging

New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

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