Neoadjuvant chemotherapy for locally advanced stage (IB2-IIA2-IIB) cervical carcinoma: Experience of a tertiary center and comprehensive review of the literature

Çakır, Caner; Kılıç, Fatih; Dur, Rıza; Yüksel, Dilek; Ünsal, Mehmet; Korkmaz, Vakkaş; Kılıç, Çiğdem; Cömert, Günsu Kimyon; Boran, Nurettin; Türkmen, Osman; Koç, Sevgi; Turan, Taner

doi:10.4274/tjod.galenos.2021.70493

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vincristine, irinotecan, etoposide, and paclitaxel are plant-derived drugs used to treat cervical cancer clinically, alone, and as neoadjuvant chemotherapy with other chemotherapeutics such as cisplatin [5][6][7][8][9]; natural products are essential molecules since they comprise 50% of anti-tumor drugs [10,11]. Iridoids, a diverse class of secondary metabolites, are present in numerous plant families, with a prevalent occurrence in Apocynaceae, Loganiaceae, Scrophulariaceae, and others [12,13].…”

Section: Introductionmentioning

confidence: 99%

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

López-López,

Razo-Hernández,

Millán-Pacheco

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Cervical cancer is a malignant neoplastic disease, mainly associated to HPV infection, with high mortality rates. Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in different cancer cell types. Geniposide and its aglycone Genipin have been assessed against different types of cancer. In this work, both iridoids were evaluated against HeLa and three different cervical cancer cell lines. Furthermore, we performed a SAR analysis incorporating 13 iridoids with a high structural similarity to Geniposide and Genipin, also tested in the HeLa cell line and at the same treatment time. Derived from this analysis, we found that the dipole moment (magnitude and direction) is key for their cytotoxic activity in the HeLa cell line. Then, we proceeded to the ligand-based design of new Genipin derivatives through a QSAR model (R2 = 87.95 and Q2 = 62.33) that incorporates different quantum mechanic molecular descriptor types (ρ, ΔPSA, ∆Polarizability2, and logS). Derived from the ligand-based design, we observed that the presence of an aldehyde or a hydroxymethyl in C4, hydroxyls in C1, C6, and C8, and the lack of the double bond in C7–C8 increased the predicted biological activity of the iridoids. Finally, ten simple iridoids (D9, D107, D35, D36, D55, D56, D58, D60, D61, and D62) are proposed as potential cytotoxic agents against the HeLa cell line based on their predicted IC50 value and electrostatic features.

show abstract

Section: Introductionmentioning

confidence: 99%

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

López-López,

Razo-Hernández,

Millán-Pacheco

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…A recently published retrospective study has underscored the efficacy of surgery in patients with tumor volumes measuring <4 cm after neoadjuvant chemotherapy. 4 This finding raises the tantalizing prospect that surgery may yield superior outcomes in patients with tumor diameters <4 cm after neoadjuvant chemotherapy. In light of these observations, we posit that future investigations may contemplate randomized allocation of patients to either chemoradiotherapy or surgery on the basis of their clinical responses after neoadjuvant chemotherapy.…”

mentioning

confidence: 98%

Interpretation of the EORTC-55954 Trial: Does the Response to Neoadjuvant Chemotherapy Have an Effect on Disease Outcome?

Mutlu Sütcüoğlu,

Sütcüoğlu

2024

JCO

View full text Add to dashboard Cite

Neoadjuvant chemotherapy for locally advanced stage (IB2-IIA2-IIB) cervical carcinoma: Experience of a tertiary center and comprehensive review of the literature

Cited by 2 publications

References 0 publications

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

Interpretation of the EORTC-55954 Trial: Does the Response to Neoadjuvant Chemotherapy Have an Effect on Disease Outcome?

Contact Info

Product

Resources

About